CoChat
Sign Up
Cited by 792Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementDermatologic Treatments and Research

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Impaired wound healing

Menke, Nathan B., Ward, Kevin R., Witten, Tarynn M., Bonchev, Danail G., Diegelmann, Robert F.·2007·Clinics in Dermatology
DOI 10.1016/j.clindermatol.2006.12.005
Open this paper in CoChat — free account

Abstract

Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. One of the underlying mechanisms responsible for the failure of chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining. Underappreciation of the inherent complexity of the healing wound has led to the failure of monotherapies, with no significant reduction in wound healing times. A model of the inflammatory profile of a nonhealing wound is one in which the equilibrium between synthesis and degradation has been shifted toward degradation. This review summarizes the current information regarding acute wound healing responses as contrasted to the delayed response characteristic of chronic wounds. In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.clindermatol.2006.12.005

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 45 references

Cited by

Sorted by citations

See all 792

Related

Metadata

Authors
Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., & Diegelmann, R. F.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Diegelmann, Robert F.
ORCID
Venue
Clinics in Dermatology
Publisher
Elsevier BV
Published
2007-01
Volume
25
Issue
1
Pages
19-25
ISSN
0738-081X (ISSN-L)
DOI
10.1016/j.clindermatol.2006.12.005
OpenAlex
W2043960873
Cited by
792
References
45
Citations by year
2026: 16 · 2025: 38 · 2024: 47 · 2023: 64 · 2022: 49 · 2021: 76 · 2020: 60 · 2019: 38 · 2018: 56 · 2017: 37 · 2016: 51 · 2015: 44 · 2014: 45 · 2013: 36 · 2012: 47
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinics in Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
delayed wound healing, chronic wounds, chronic inflammation, acute wound healing, extracellular matrix degradation, complexity theory, wound healing model
MeSH terms
Acute Disease, Chronic Disease, Humans, Inflammation, Models, Theoretical, Skin, Skin Ulcer, Wound Healing, Wounds, Penetrating, Treatment Failure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review