Neuropsychiatric factors in sensitive skin
Abstract
Sensitive skin is a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that normally should not provoke such sensations. The worldwide prevalence of sensitive skin is approximately 40%. Clinical, histologic, biochemical, and therapeutic data show that this condition is related to changes in epidermal nerve endings with subsequent hyperreactivity and neurogenic inflammation; hence, sensitive skin is not a psychosomatic disorder, although psychologic consequences are possible.
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Sensitive skin is a common disorder that can induce changes in quality of life and has psychological consequences.
“In general, sensitive skin is a common disorder that can induce changes in the quality of life and has psychological consequences [6].”
The molecular mechanism involves release of Nrf2 from Keap1 and subsequent binding to the antioxidant response element (ARE) present in the promoter region of genes for antioxidant proteins and enzymes.
“This molecular mechanism has been described, where it involves the release of Nrf2 (transcription factor) from Keap 1 (its cytoplasmic binding protein) and subsequent binding to the antioxidant response element (ARE) that are present in the promoter region of genes for antioxidant proteins and enzymes [6,97].”
Nrf2 activation increases antioxidant gene expression of several proteins.
“since Nrf2 activation is known to increase antioxidants gene expression of several proteins”
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- Authors
- Misery, L.
- Affiliations
- Université de Bretagne Occidentale (FR)
- Corresponding author
- Misery, Laurent
- ORCID
- Misery, Laurent
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 35
- Issue
- 3
- Pages
- 281-284
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2582586712
- Cited by
- 28
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 3
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- sensitive skin, pruritus, neurogenic inflammation, hyperreactivity, psychosomatic factors
- MeSH terms
- Humans, Hypesthesia, Pain, Pruritus, Skin, Skin Diseases, Somatosensory Disorders
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