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Cited by 155Multiple Sclerosis Research StudiesCancer survivorship and careTryptophan and brain disorders

The DOI matches its Crossref record; 119 of the 122 references it cites were found in a registry or an index.

Psychological aspects of multiple sclerosis

Sá, Maria José·2008·Clinical Neurology and Neurosurgery
DOI 10.1016/j.clineuro.2007.10.001
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Abstract

A significant incidence and prevalence of psychological disorders in multiple sclerosis (MS) has been reported. Their underlying mechanisms and the extent to which they are reactive to psychosocial factors or symptoms of the pathological process itself, remain unclear. Depression is the predominant psychological disturbance with lifetime prevalence around 50% and annual prevalence of 20%. Depression is commoner during relapses, may exacerbate fatigue and cognitive dysfunction and no firm evidence exists of its induction by interferon; instead, treating depression improves adherence to disease-modifying drugs. Anxiety is also frequent, occurs in newly diagnosed patients, and its co-morbidity with depression has been suggested to increase the rate of suicidal ideation. The relationship between stress and MS is an attractive issue because some studies pointed to an association between stressful life-events and MS onset/relapses; however, the evidence supporting this hypothesis is not conclusive so far. Other psychiatric illnesses, as bipolar affective disorder, pathological laughing and crying or psychosis occur less frequently in MS. Therapeutic strategies include psychotherapy, cognitive behavioural therapy, strengthen of coping, and specific medications. The "art" of the MS team in providing the best individualized care is emphasized, aiming to reduce the burden of the disease and improve the patients' quality of life.

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Crossref · 10.1016/j.clineuro.2007.10.001

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Research works printed but not linked: 2

  1. Thomas, 2007, Psychological interventions for multiple sclerosis (review), vol. 1
  2. Davidson, 1969, Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature, Br J Psychiatry, 4, 113

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Metadata

Authors
Sá, M. J.
Venue
Clinical Neurology and Neurosurgery
Publisher
Elsevier BV
Published
2008-11
Volume
110
Issue
9
Pages
868-877
ISSN
0303-8467 (ISSN-L)
DOI
10.1016/j.clineuro.2007.10.001
OpenAlex
W2075214874
Cited by
155
References
122
Citations by year
2026: 5 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 10
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Neurology and Neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
multiple sclerosis, depression, anxiety, psychological comorbidity, relapse, fatigue, cognitive impairment, stress, life events, bipolar disorder, psychosomatic symptoms, psychosis, suicidal ideation, psychosocial factors, coping, cognitive behavioral therapy, psychotherapy, quality of life, individualized care
MeSH terms
Anxiety, Depression, Humans, Multiple Sclerosis, Psychotic Disorders, Stress, Psychological, Mood Disorders

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