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Cited by 19Multiple Sclerosis Research StudiesPolyomavirus and related diseasesPeripheral Neuropathies and Disorders

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Prevalence of cerebrospinal fluid oligoclonal IgG bands in Greek patients with clinically isolated syndrome and multiple sclerosis

Andreadou, E., Chatzipanagiotou, S., Constantinides, V.C., Rombos, A., Stamboulis, E., Nicolaou, C.·2013·Clinical Neurology and Neurosurgery
DOI 10.1016/j.clineuro.2013.07.026
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Abstract

Unlabelled Lower prevalence of cerebrospinal fluid oligoclonal IgG bands (IgG-OCBs) has been reported in multiple sclerosis (MS) patients from Southern Europe compared to other western countries. Objectives We aimed to determine the prevalence of CSF OCBs in Greek MS patients and to examine their relation with some selected clinical and demographical features. Methods Included patients fulfilled the 2005 McDonald criteria for definite MS (CDMS) or clinically isolated syndrome (CIS) and had a spinal tap performed between 2006 and 2010. Paired CSF and plasma samples were analyzed using isoelectric focusing followed by IgG-specific immunofixation. A pattern of two or more bands present only in the CSF was defined as positive. OCB status was correlated with age at disease onset, initial symptomatology, relapse rate, disease subtype, disease duration, medication, EDSS score and MSSS. Results Of the 231 included patients (53.2% with CDMS and 48.6% with CIS) 67.5% had OCBs. The prevalence of positive patterns did not differ between CIS and CDMS patients (67.6% vs. 67.5%, respectively). OCB-positive patients were younger than OCB-negative patients (35.2±10.3 vs. 38.7±11.8 years respectively, p=0.022) and had more frequently cervical spinal cord lesions (x2=7.08, p=0.008). No difference was observed between the two subgroups in the other studied disease parameters. Conclusion Despite the lower frequency of positive IgG-OCB patterns in our patients, both subgroups were mostly similar w…

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Research works printed but not linked: 31

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Cited by

Metadata

Authors
Andreadou, E., Chatzipanagiotou, S., Constantinides, V. C., Rombos, A., Stamboulis, E., & Nicolaou, C.
Affiliations
Eginition Hospital (GR)
Corresponding author
Andreadou, E.
ORCID
Venue
Clinical Neurology and Neurosurgery
Publisher
Elsevier BV
Published
2013-10
Volume
115
Issue
10
Pages
2094-2098
ISSN
0303-8467 (ISSN-L)
DOI
10.1016/j.clineuro.2013.07.026
OpenAlex
W2104218092
Cited by
19
References
0
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Neurology and Neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
multiple sclerosis, clinically isolated syndrome, prevalence, Greek patients, cervical spinal cord injury, age of onset, prognostic value, disease subtypes, Expanded Disability Status Scale
MeSH terms
Adult, Age Factors, Female, Greece, Humans, Immunoglobulin G, Immunoelectrophoresis, Male, Middle Aged, Multiple Sclerosis, Recurrence, Spinal Cord, Prevalence, Age of Onset, Oligoclonal Bands

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