Different Association between Physical Activity and Physical Function According to Walking Independence in Hospital-Based Rehabilitation Program Patients with Sub-Acute Stroke
Abstract
Objective To investigate the association between physical activity and physical function in ambulatory independent and non-independent patients with sub-acute stroke during hospitalization.Methods This cross-sectional observational study included 107 patients with stroke admitted to a rehabilitation unit. The average daily number of steps taken was considered as physical activity. Physical function was assessed using the 6 min walk test (6MWT), lower limb Fugl-Meyer assessment (FMA), and Berg balance scale (BBS). Walking independence was assessed using the functional ambulation category (FAC). The subjects were divided into a walking independence group (FAC ≥ 4) and a non-independence group (FAC ≤ 3). Multiple regression analysis was used to investigate the relationship between the daily number of steps and physical function in each group.Results The daily number of steps (p < 0.001), lower limb FMA (p < 0.001), 6MWT (p < 0.001), and BBS (p < 0.001) were higher in the independent walking group than in the non-walking group. The daily number of steps in the walking independence group was significantly associated with the 6MWT (standard β = 0.489, p = 0.039). In the non-independence group, the daily number of steps was significantly associated with the BBS (standard β = 0.594, p < 0.001).Conclusion Physical activity was associated with walking endurance in patients with ambulatory independence, even though it was associated with balance function in patients with non-ambulatory independence.
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Non-ambulatory stroke survivors are at the highest risk of inactivity, which is the greatest challenge to the healthcare system.
“In turn, non-ambulatory stroke survivors are at the highest risk of inactivity, which is the greatest challenge to the healthcare system [9,13].”
From Physical Activity, Psychological and Functional Outcomes in Non-Ambulatory Stroke Patients during Rehabilitation—A Pilot Study (2022) · cites this paper as [13]
Cites
Statistical power analyses using G∗Power 3.1: tests for correlation and regression analyses
Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009) · Behavior Research Methods · doi:10.3758/brm.41.4.1149 · Cited by 37,615 · see citing works
A Caution Regarding Rules of Thumb for Variance Inflation Factors
O’brien, R. M. (2007) · Quality & Quantity · doi:10.1007/s11135-006-9018-6 · Cited by 11,217 · see citing works
ATS Statement: Guidelines for the Six-Minute Walk Test
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.166.1.at1102 · Cited by 11,195 · see citing works
Measuring balance in the elderly: validation of an instrument.
Berg, K., Wood-Dauphinée, S., Williams, J. I., & Maki, B. E. (1992) · PubMed · Cited by 2,961 · see citing works
Gladstone, D. J., Danells, C. J., & Black, S. E. (2002) · Neurorehabilitation and neural repair · doi:10.1177/154596802401105171 · Cited by 2,042 · see citing works
Clinical Gait Assessment in the Neurologically Impaired
Holden, M. K., Gill, K. M., Magliozzi, M. R., Nathan, J., & Piehl-Baker, L. (1984) · Physical Therapy · doi:10.1093/ptj/64.1.35 · Cited by 1,499 · see citing works
Usefulness of the Berg Balance Scale in Stroke Rehabilitation: A Systematic Review
Blum, L. M., & Korner-Bitensky, N. A. (2008) · Physical Therapy · doi:10.2522/ptj.20070205 · Cited by 1,211 · see citing works
Mehrholz, J., Wagner, K., Rutte, K., Meiβner, D., & Pohl, M. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.06.764 · Cited by 831 · see citing works
Reduced Ambulatory Activity After Stroke: The Role of Balance, Gait, and Cardiovascular Fitness
Michael, K. M., Allen, J. K., & Macko, R. F. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.12.026 · Cited by 506 · see citing works
Determinants of Walking Function After Stroke: Differences by Deficit Severity
Patterson, S. L., Forrester, L. W., Rodgers, M. M., Ryan, A. S., Ivey, F. M., Sorkin, J. D., & Macko, R. F. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2006.10.025 · Cited by 356 · see citing works
Factors Associated With Post-Stroke Physical Activity: A Systematic Review and Meta-Analysis
Thilarajah, S., Mentiplay, B. F., Bower, K. J., Tan, D., Pua, Y. H., Williams, G., Koh, G., & Clark, R. A. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2017.09.117 · Cited by 310 · see citing works
Predicting Home and Community Walking Activity Poststroke
Fulk, G. D., He, Y., Boyne, P., & Dunning, K. K. (2017) · Stroke · doi:10.1161/strokeaha.116.015309 · Cited by 308 · see citing works
Time Course of Trunk, Arm, Leg, and Functional Recovery After Ischemic Stroke
Verheyden, G., Nieuwboer, A., Wit, L. D., Thijs, V., Dobbelaere, J., Devos, H., Severijns, D., Vanbeveren, S., & Weerdt, W. D. (2007) · Neurorehabilitation and neural repair · doi:10.1177/1545968307305456 · Cited by 242 · see citing works
Rand, D., Eng, J. J., Tang, P., Hung, C., & Jeng, J. (2010) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-8-80 · Cited by 129 · see citing works
Timed Walking Tests Correlate With Daily Step Activity In Persons With Stroke
Mudge, S., & Stott, N. S. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.07.025 · Cited by 115 · see citing works
Kramer, S. F., Hung, S., & Brodtmann, A. G. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0949-4 · Cited by 109 · see citing works
Physical Activity Early after Stroke and Its Association to Functional Outcome 3 Months Later
Askim, T., Bernhardt, J., Salvesen, Ø., & Indredavik, B. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.12.011 · Cited by 91 · see citing works
Klassen, T. D., Simpson, L. A., Lim, S. B., Louie, D. R., Parappilly, B., Sakakibara, B. M., Zbogar, D., & Eng, J. J. (2015) · Physical Therapy · doi:10.2522/ptj.20140611 · Cited by 89 · see citing works
Excessive sedentary time during in-patient stroke rehabilitation
Barrett, M., Snow, J. C., Kirkland, M. C., Kelly, L. P., Gehue, M., Downer, M. B., McCarthy, J., & Ploughman, M. (2018) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2018.1458461 · Cited by 79 · see citing works
Kono, Y., Kawajiri, H., Kamisaka, K., Kamiya, K., Akao, K., Asai, C., Inuzuka, K., & Yamada, S. (2014) · International Journal of Stroke · doi:10.1111/ijs.12392 · Cited by 78 · see citing works
Sedentary Behaviour and Physical Activity of People with Stroke in Rehabilitation Hospitals
Sjöholm, A., Skarin, M., Churilov, L. P., Nilsson, M., Bernhardt, J., & Linden, T. K. A. (2014) · Stroke Research and Treatment · doi:10.1155/2014/591897 · Cited by 75 · see citing works
Klassen, T. D., Semrau, J. A., Dukelow, S. P., Bayley, M. T., Hill, M. D., & Eng, J. J. (2017) · Stroke · doi:10.1161/strokeaha.117.018175 · Cited by 65 · see citing works
Low gait speed is associated with low physical activity and high sedentary time following stroke
Fini, N. A., Bernhardt, J. A., & Holland, A. E. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2019.1691273 · Cited by 51 · see citing works
Physical Activity Level Among Stroke Patients Hospitalized in a Rehabilitation Unit
Lacroix, J., Daviet, J., Borel, B., Kammoun, B., Salle, J., & Mandigout, S. (2015) · PM&R · doi:10.1016/j.pmrj.2015.06.011 · Cited by 46 · see citing works
A mapping study on physical activity in stroke rehabilitation: Establishing the baseline
Skarin, M., Sjöholm, A., Nilsson, �., Nilsson, M., Bernhardt, J. A., & Linden, T. K. A. (2013) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-1214 · Cited by 46 · see citing works
Reference value of 6-minute walk distance in patients with sub-acute stroke
Kubo, H., Nozoe, M., Kanai, M., Furuichi, A., Ōnishi, A., Kajimoto, K., Mase, K., & Shimada, S. (2019) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2019.1704372 · Cited by 25 · see citing works
Shimizu, N., Hashidate, H., Ota, T., & Yatsunami, M. (2019) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2019.1649916 · Cited by 24 · see citing works
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Błaszcz, M., Prucnal, N., Wrześniewski, K., Pasiut, S., Mika, P., Kucia, M., Stach, B., Woźniak, M., & Mirek, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247260 · Cited by 12 · see citing works
“In turn, non-ambulatory stroke survivors are at the highest risk of inactivity, which is the greatest challenge to the healthcare system [9,13].”
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Kubo, H., Kanai, M., Nozoe, M., Inamoto, A., Taguchi, A., Makihara, A., Hosokawa, D., Mitsue, S., Asai, T., & Shimada, S. (2023) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2023.04.030 · Cited by 11 · see citing works
Kim, S.-Y., Cho, W.-S., Park, C.-B., & Kim, B.-G. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062036 · Cited by 5 · see citing works
“This suggests that enhancing balance may contribute to improved gait independence [39].”
Tsujinaka, R., Yoshitani, T., Suzuki, H., Tanaka, R., Izutani, Y., & Morimoto, K. (2024) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000651
Kai, G., Ogura, K., Ueno, K., Sato, K., Miki, T., Soeda, S., Iida, K., Kanai, M., Nozoe, M., & Kamiya, K. (2026) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2026.103311
Kai, G., Noda, T., Ueno, K., Ogura, K., Miki, T., Yamashita, M., Kanai, M., Nozoe, M., & Kamiya, K. (2026) · Heart and Vessels · doi:10.1007/s00380-026-02717-9
Kubo, H., Miyata, K., Tamura, S., Kobayashi, S., Nozoe, M., Inamoto, A., Kajimoto, K., Nishihara, S., YAMAMOTO, N., & Shimada, S. (2026) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2026.08.002
Kubo, H., Kobayashi, S., Kimura, Y., Yoshida, K., Takeuchi, M., Tanaka, S., Kai, T., Suzuki, Y., Moronaga, K., Yamamoto, S., et al. (2026) · Neurorehabilitation and neural repair · doi:10.1177/15459683261479717
- Authors
- Kubo, H., Kanai, M., Nozoe, M., Inamoto, A., Taguchi, A., Mase, K., & Shimada, S.
- Affiliations
- Itami Kousei Neurosurgical Hospital (JP)
- Konan Women's University (JP)
- Corresponding author
- Kubo, Hiroki
- Venue
- Clinical Neurology and Neurosurgery
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 215
- Pages
- 107202
- ISSN
- 0303-8467 (ISSN-L)
- OpenAlex
- W4220796677
- Cited by
- 8
- References
- 27
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinical Neurology and Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- physical activity, physical function, subacute stroke, walking independence, daily step count, walking endurance, balance function, inpatient stroke rehabilitation, Functional Ambulation Category
- MeSH terms
- Stroke Rehabilitation, Cross-Sectional Studies, Postural Balance, Hospitals, Humans, Walking, Stroke
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