A review of explainable AI techniques and their evaluation in mammography for breast cancer screening
Open accessAbstract
Explainable AI (XAI) methods are gaining prominence in medical imaging, addressing the critical need for transparency and trust in AI-driven diagnostic tools. Mammography, as the cornerstone of early breast cancer detection, holds immense potential for improving outcomes when integrated with AI solutions. However, widespread adoption of AI in clinical settings depends on explainability, which enhances clinicians' confidence in these tools. By exploring various XAI techniques and evaluating their strengths and weaknesses, researchers can significantly advance precision medicine. This review synthesizes existing research on XAI in medical imaging, focusing on mammography, a domain often overlooked in XAI studies. It provides a comparative analysis of XAI techniques employed in mammography, assessing their diagnostic efficacy and identifying research gaps, such as the lack of specialized evaluation frameworks. Additionally, the review examines evaluation methods for XAI in medical imaging and proposes modifications tailored to mammography diagnostics. Insights from XAI advancements in other fields are also explored for their potential to enhance interpretability and clinical relevance in breast cancer detection. The study concludes by highlighting critical research gaps and proposing directions for developing reliable, effective AI models that integrate XAI to transform breast cancer diagnostics.
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Lack of standardized quantitative metrics for explanation quality is the most critical methodological gap in mammography XAI.
“identified the lack of standardized quantitative metrics for explanation quality as the most critical methodological gap in the field”
From A generative AI multi-agent framework with integrated XAI governance for cancer diagnostics: from multi-omics interpretation to lifestyle risk stratification (2026) · cites this paper as Shifa et al., 2025
Existing XAI solutions in mammography focus on lesion localization and saliency maps rather than actionable clinical insights.
“existing solutions focus on lesion localization and saliency maps rather than actionable clinical insights”
From A generative AI multi-agent framework with integrated XAI governance for cancer diagnostics: from multi-omics interpretation to lifestyle risk stratification (2026) · cites this paper as Shifa et al., 2025
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Enabling Uncertainty Measurement in Multi-subregion Tumor Segmentation: BraTS 2025 Pediatrics
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A COMPREHENSIVE SURVEY ON AI-DRIVEN MAMMOGRAPHY-BASED BREAST CANCER DETECTION
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Embedded Shift Evolution in Explainable Deep Learning Systems
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- Authors
- Shifa, N., Saleh, M., Akbari, Y., & Al Maadeed, S.
- Affiliations
- Qatar University (QA)
- Corresponding author
- Shifa, Noora
- Saleh, Moutaz
- Akbari, Younes
- Venue
- Clinical Imaging
- Publisher
- Elsevier BV
- Published
- 2025-07
- Volume
- 123
- Pages
- 110492
- ISSN
- 0899-7071 (ISSN-L)
- OpenAlex
- W4410314111
- Cited by
- 45
- References
- 75
- Citations by year
- 2026: 33 · 2025: 12
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Imaging (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Qatar Research, Development and Innovation Council
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Keywords
- explainable AI, mammography, breast cancer screening, interpretability, clinical trust in AI, breast cancer early detection, medical image analysis, clinical implementation of AI
- MeSH terms
- Artificial Intelligence, Breast Neoplasms, Female, Humans, Mammography, Early Detection of Cancer
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