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Cited by 27Transcranial Magnetic Stimulation StudiesMotor Control and AdaptationPeripheral Nerve Disorders

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Changes in corticospinal transmission following 8 weeks of ankle joint immobilization

Leukel, Christian, Taube, Wolfgang, Rittweger, Jörn, Gollhofer, Albert, Ducos, Michel, Weber, Tobias, Lundbye-Jensen, Jesper·2015·Clinical Neurophysiology
DOI 10.1016/j.clinph.2014.04.002
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Abstract

Objectives Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er) (polysynaptic) corticospinal pathways. Methods 9 subjects underwent 8weeks of unilateral ankle joint immobilization during daytime, 7 subjects served as controls. The measures obtained before and after immobilization included stretch- and H-reflexes assessing excitability of the spinal reflex circuitries, TMS recruitment curves estimating overall changes in corticospinal excitability, and Hcond. Results TMS recruitment curves showed an overall increase in corticospinal excitability following immobilization. Importantly, Hcond revealed significant facilitation of conditioned reflexes, but only for longer conditioning intervals, suggesting that immobilization increased excitability only of slower, indirect corticospinal pathways. No changes were observed in the control group. Immobilization had no significant effects on spinal reflex measures. Conclusions 8weeks of ankle joint immobilization was accompanied by pathway-specific modulation of corticospinal transmission. Significance It is particularly interesting that fast corticospinal projections were unaffected as these are…

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Crossref · 10.1016/j.clinph.2014.04.002

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  • Sensory input is processed and integrated differently into motor programs after periods of disuse, and the excitability of interneurons of the motor cortex and spinal alpha motoneurons is modulated in response to immobilization.

    “Sensory input is processed and integrated differently into motor programs after periods of disuse (93), and the excitability of interneurons of the motor cortex and spinal alpha motoneurons is modulated in response to immobilization (94).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [94]

  • Neuronal factors have been specified by increased coactivation of antagonistic muscles in voluntary movement, increasing the vector force that counteracts movement direction, as well as adaptations on the spinal circuitries and supraspinal level within the central nervous system.

    “However, the neuronal factors have been specified by an increased coactivation of antagonistic muscles in voluntary movement (92) increasing the vector force, which counteracts the movement direction as well as adaptations on the spinal circuitries and supraspinal level within the central nervous system (93, 94).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [94]

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Metadata

Authors
Leukel, C., Taube, W., Rittweger, J., Gollhofer, A., Ducos, M., Weber, T., & Lundbye-Jensen, J.
Affiliations
  • University of Fribourg (CH)
  • Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
  • University of Freiburg (DE)
Corresponding author
Leukel, Christian
ORCID
Venue
Clinical Neurophysiology
Publisher
Elsevier BV
Published
2015-01
Volume
126
Issue
1
Pages
131-139
ISSN
1388-2457 (ISSN-L)
DOI
10.1016/j.clinph.2014.04.002
OpenAlex
W2036037911
Cited by
27
References
38
Citations by year
2025: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 1
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
  • elib (German Aerospace Center) (submittedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Deutsches Zentrum für Luft- und Raumfahrt
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
Keywords
corticospinal excitability, primary motor cortex, spinal reflexes, joint immobilization
MeSH terms
Adult, Ankle Joint, H-Reflex, Humans, Male, Motor Cortex, Movement, Synaptic Transmission, Pyramidal Tracts, Restraint, Physical, Muscle, Skeletal, Evoked Potentials, Motor, Transcranial Magnetic Stimulation

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