Vitamin C in clinical therapeutics
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The data on the effect of vitamin C on clinical outcomes in patients undergoing cardiac surgery is still insufficient to draw firm conclusions.
“The data on the effect of vitamin C on clinical outcomes in patients undergoing cardiac surgery is still insufficient to draw firm conclusions [191,192,193,194].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [191]
Some recent systematic reviews and meta-analyses suggested that vitamin C significantly decreased the incidence of atrial fibrillation, ventilation time, length-of-stay in the intensive care unit, and hospital length-of-stay, but it had no significant effect on in-hospital mortality or incidence of stroke, acute kidney injury, or ventricular arrhythmia in cardiac surgery patients.
“Some recent systematic reviews and meta-analyses suggested that vitamin C significantly decreased the incidence of atrial fibrillation, ventilation time, length-of-stay in the intensive care unit, and hospital length-of-stay, but it had no significant effect on in-hospital mortality or incidence of stroke, acute kidney injury, or ventricular arrhythmia in cardiac surgery patients.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [191]
Notwithstanding that the effect is absent in the general population, vitamin C can be effective under specific conditions, such as low levels of vitamin C, e.g., in people under physical stress.
“Notwithstanding that the effect is absent in the general population, vitamin C can be effective under specific conditions, such as low levels of vitamin C, e.g., in people under physical stress [6,191,195,198].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [191]
Cites
Vitamin C for preventing and treating the common cold
Hemilä, H., & Chalker, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000980.pub4 · Cited by 869 · see citing works
Self-citationVitamins E and C in the Prevention of Prostate and Total Cancer in Men
Gaziano, J. M., Glynn, R. J., Christen, W. G., Kurth, T., Belanger, C. F., MacFadyen, J. G., Bubes, V. Y., Manson, J. E., Sesso, H. D., & Buring, J. E. (2008) · JAMA · doi:10.1001/jama.2008.862 · Cited by 519 · see citing works
Hemilä, H. (2017) · Nutrients · doi:10.3390/nu9040339 · Cited by 461 · see citing works
Self-citationPadayatty, S. J., Sun, A. Y., Chen, Q., Espey, M. G., Drisko, J., & Levine, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011414 · Cited by 304 · see citing works
Juraschek, S. P., Güallar, E., Appel, L. J., & Miller, E. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027995 · Cited by 294 · see citing works
Ashor, A. W., Lara, J., Mathers, J. C., & Siervo, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.004 · Cited by 185 · see citing works
Sadat, U., Usman, A., Gillard, J. H., & Boyle, J. R. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.065 · Cited by 116 · see citing works
Hemilä, H., & Suonsyrjä, T. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0478-5 · Cited by 94 · see citing works
Self-citationVitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis
Hemilä, H. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002416 · Cited by 63 · see citing works
Self-citationThe effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trial
Constantini, N., Dubnov‐Raz, G., Ben-Bassat, E., Berry, E. M., Cohen, A. H., & Hemilä, H. (2010) · European Journal of Pediatrics · doi:10.1007/s00431-010-1270-z · Cited by 45 · see citing works
Self-citationHemilä, H. (2013) · Työväentutkimus Vuosikirja · doi:10.13140/2.1.2280.5280 · Cited by 3 · see citing works
Self-citationShader, R. I. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.04.001 · Cited by 2 · see citing works
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1 of the 13 references couldn’t be matched to a known paper.
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Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Response to the Letter to the Editor
Shader, R. I. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.08.004
Holder, K., Galvan, B., Manna, P. R., Gray, Z. C., & Reddy, P. H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00014-3
- Authors
- Hemilä, H.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Hemilä, Harri
- ORCID
- Hemilä, Harri
- Venue
- Clinical Therapeutics
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 39
- Issue
- 10
- Pages
- 2110-2112
- ISSN
- 0149-2918 (ISSN-L)
- OpenAlex
- W2753784793
- Cited by
- 3
- References
- 13
- Citations by year
- 2023: 1 · 2021: 1 · 2017: 1
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Clinical Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- vitamin C, vitamin C supplementation, disease prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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