The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.
Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures
Abstract
Aim To evaluate the effects of a protein-rich liquid supplementation, alone or in combination with the anabolic steroid nandrolone decanoate, on body composition, activities of daily living (ADL) status and the health-related quality of life (HRQoL) after a femoral neck fracture. Methods Sixty women, aged 83 +/- 5 years (mean +/- SD), BMI < 24 kg/m2 (20.4 +/- 2 kg/m2 ) and capable of co-operating, with a femoral neck fracture treated with internal fixation, were randomised to open treatment during 6 months with a protein-rich liquid formula alone (PR, Fortimel, 200 ml/day, 20 g protein/day) or in combination with nandrolone decanoate (PR/N, Deca-Durabol 25 mg i.m./3 weeks) or to a control group (C). The patients were re-examined after 6 and 12 months regarding body weight (BW), lean body mass (LBM, DXA), ADL status according to Katz, HRQoL according to EQ 5-D and fracture healing. Results LBM decreased in the C (-1.2 +/- 2 kg) and PR groups (-1.2 +/- 1 kg) but remained the same in the PR/N group (0.3 +/- 1 kg) (P < 0.05 between groups). ADL remained at a high level in the two intervention groups but declined significantly in the C group (P < 0.005 between groups). The decline in HRQoL was least pronounced in the PR/N group at 6 months (P < 0.05 between groups). Patients with fracture healing complications lost more BW (P < 0.05) and LBM (P < 0.01) than patients with uneventful fracture healing. Conclusion Protein-rich liquid supplementation in combination with nandrolone given for 6 months to lean elderly women after a femoral neck fracture may positively affect LBM, ADL and HRQoL.
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“Of 7 RCTs exploring modifications of ADLs, most found no significant differences between high-protein ONS groups and controls, whereas one trial found improvement for people in the ONS group.86,230”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [230]
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
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Metadata
- Authors
- Tidermark, J., Ponzer, S., Carlsson, P., Söderqvist, A., Brismar, K., Tengstrand, B., & Cederholm, T.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Tidermark, Jan
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 23
- Issue
- 4
- Pages
- 587-596
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2057430676
- Cited by
- 127
- References
- 49
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 6
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- femoral neck fracture, nandrolone decanoate, lean body mass, body composition, activities of daily living, health-related quality of life, fracture healing complications, internal fixation, anabolic steroids
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Body Composition, Dietary Proteins, Female, Femoral Neck Fractures, Food, Formulated, Humans, Nandrolone, Nutritional Status, Quality of Life, Nutrition Assessment, Treatment Outcome, Fracture Healing, Anabolic Agents
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