Three month intervention with protein and energy rich supplements improve muscle function and quality of life in malnourished patients with non-neoplastic gastrointestinal disease—A randomized controlled trial
Abstract
Background Malnutrition is a common problem in patients with digestive disease and is associated with impaired outcome. Objective We investigated the effect of a three-month post-hospital nutritional intervention with high protein and energy supplements on body composition, muscle function and quality of life (QoL) in malnourished GI patients. Patients and intervention Eighty malnourished patients with benign digestive disease were randomized to receive either oral nutritional supplements (ONS) for three months in addition to dietary counselling (DC) (ONS patients) or only dietary counselling (DC patients). Methods Nutritional status was determined with the subjective global assessment, body composition by bioelectrical impedance and anthropometry, muscle function with hand-grip strength and peak flow. QoL was assessed by the 36-item short-form questionnaire. Results Age, body cell mass (BCM), muscle function, gender distribution and QoL did not differ between ONS patients (n=38) and DC patients (n=42) at baseline. Body weight and BCM improved significantly in both groups after three months. However, hand-grip strength (26.1+/-11.3-31.5+/-10.1 kg, p Conclusion A three month intervention with high protein oral supplements improves outcome in malnourished patients with digestive disease in terms of functional status, QoL and rehospitalization.
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HGS and peak expiratory flow increased after three months only in intervention patients (grip strength improved from 26.1±11.3 to 31.5±10.1 kg, p<0.0001; peak flow from 329.2±124.0 to 388.9±108.4 l/min, p=0.004).
“HGS and peak expiratory flow increased after three months only in the intervention patients (grip strength improved from 26.1 ± 11.3 to 31.5 ± 10.1 kg, p < 0.0001; and peak flow from 329.2 ± 124.0 to 388.9 ± 108.4 l/ min, p ¼ 0.004)”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [124]
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WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392 · see citing works
Protein and energy supplementation in elderly people at risk from malnutrition
Milne, A. C., Potter, J., Vivanti, A., & Avenell, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub3 · Cited by 849 · see citing works
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674 · see citing works
ESPEN practical guideline: clinical nutrition in liver disease
Bischoff, S. C., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Plauth, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.001 · Cited by 383 · see citing works
ESPEN guidelines on nutritional support for polymorbid internal medicine patients
Gomes, F., Schuetz, P., Bounoure, L., Austin, P., Ballesteros-Pomar, M., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., Poulia, K.-A., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.06.025 · Cited by 363 · see citing works
Self-citationStratton, R. J., Hébuterne, X., & Elia, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.002 · Cited by 183 · see citing works
ESPEN guideline on nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schuetz, P., Stumpf, F., Austin, P., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.023 · Cited by 105 · see citing works
“HGS and peak expiratory fl ow increased after three months only in the intervention patients (grip strength improved from 26.1 ± 11.3 to 31.5 ± 10.1 kg, p < 0.0001; and peak fl ow from 329.2 ± 124.0 to 388.9 ± 108.4 l/ min, p ¼ 0.004) [124] (Level of Evidence 1 þ ).”
InfluentialSelf-citationNorman, K., Pirlich, M., Smoliner, C., Kilbert, A., Schulzke, J. D., Ockenga, J., Lochs, H., & Reinhold, T. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.31 · Cited by 75 · see citing works
Self-citation
- Authors
- Norman, K., Kirchner, H., Freudenreich, M., Ockenga, J., Lochs, H., & Pirlich, M.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Stiftung Charité (DE)
- Corresponding author
- Pirlich, Matthias
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 27
- Issue
- 1
- Pages
- 48-56
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W1991126744
- Cited by
- 162
- References
- 2
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 18 · 2014: 13 · 2013: 13 · 2012: 9
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- malnutrition, oral nutritional supplements, muscle function, grip strength, peak expiratory flow, body composition, body cell mass, quality of life, nutrition counseling, hospital readmission
- MeSH terms
- Anthropometry, Body Composition, Energy Intake, Counseling, Dietary Proteins, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, Nutritional Status, Quality of Life, Surveys and Questionnaires, Recurrence, Nutrition Assessment, Treatment Outcome, Electric Impedance, Hand Strength, Dietary Supplements, Malnutrition
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