A multimodal nutritional intervention after discharge improves quality of life and physical function in older patients – a randomized controlled trial
Abstract
Background Many older hospitalized patients are at nutritional risk or malnourished and the nutritional condition is often further impaired during hospitalization. When discharged to own home, a "Nutrition Gap" often occurs, causing inadequate dietary intake, and potentially impeded recovery. Previously, cross-sectorial studies of single component nutritional intervention have shown a limited effect on clinically relevant outcomes. We hypothesized that a multimodal nutritional intervention is necessary to elicit a beneficial effect on clinically relevant outcomes. Methods A randomized controlled trial was performed for a period of 16 weeks. At discharge, the intervention group (IG) received dietetic counselling including a recommendation of daily training, an individual nutrition plan and a package containing foods and drinks covering dietary requirements for the next 24 h. Further, a goodie-bag containing samples of protein-rich milk-based drinks were provided. Information regarding recommendations of nutritional therapy after discharge was systematically and electronically communicated to the municipality. The dietician performed telephone follow-ups on day 4 and 30 and a home visit at 16 weeks. The control group (CG) received standard treatment. The primary outcome was readmissions within 6 month, secondary outcomes were Length of Stay (LOS), Health Related Quality of Life (EQ-5D-3L), nutritional status, physical function (30s-CST) and mortality. This trial was registered…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Calculated Q-5D-3L scores did not differ between groups.
“However, the calculated Q-5D-3L scores which reflect the overall multidimensional aspect of QoL did not differ between groups”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [125]
Cites
A 30-s chair-stand test as a measure of lower body strength in community-residing older adults.
Jones, C. J., Rikli, R. E., & Beam, W. C. (1999) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.1999.10608028 · Cited by 2,921 · see citing works
Schuetz, P., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Braun, N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32776-4 · Cited by 910 · see citing works
Protein and energy supplementation in elderly people at risk from malnutrition
Milne, A. C., Potter, J., Vivanti, A., & Avenell, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub3 · Cited by 849 · see citing works
Deutz, N. E., Matheson, E. M., Matarese, L. E., Luo, M., Baggs, G. E., Nelson, J. L., Hegazi, R. A., Tappenden, K. A., & Ziegler, T. R. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2015.12.010 · Cited by 472 · see citing works
Aging, exercise, and muscle protein metabolism
Koopman, R., & van Loon, L. J. C. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91551.2008 · Cited by 371 · see citing works
Marx, W., Kelly, J. T., Crichton, M., Craven, D., Collins, J., Mackay, H., Isenring, E., & Marshall, S. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.02.012 · Cited by 91 · see citing works
Nutritional follow-Up after discharge prevents readmission to hospital – a randomized clinical trial
Lindegaard Pedersen, J., Pedersen, P. U., & Damsgaard, E. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-016-0745-7 · Cited by 59 · see citing works
Pedersen, J. L., Pedersen, P. U., & Damsgaard, E. M. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0629-2 · Cited by 40 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESPEN guideline on nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schuetz, P., Stumpf, F., Austin, P., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.023 · Cited by 105 · see citing works
“…þ ) [131 ] or in older patients ( level of evidence: 1) [132], it was signi fi cantly reduced after six months of nutritional intervention in several trials ( level of evidence: 1) [116] ( level of evidence: 1 þ ) [130] ( level of evidence: 1 þþ ) [126] but not all ( level of evidence: 1 þ ) [125].”
- Authors
- Munk, T., Svendsen, J. A., Knudsen, A. W., Østergaard, T. B., Thomsen, T., Olesen, S. S., Rasmussen, H. H., & Beck, A. M.
- Affiliations
- University of Copenhagen (DK)
- Aalborg University Hospital (DK)
- Corresponding author
- Munk, Tina
- ORCID
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 40
- Issue
- 11
- Pages
- 5500-5510
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W3202432706
- Cited by
- 42
- References
- 8
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 10 · 2023: 6 · 2022: 3 · 2021: 1
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Keywords
- hospitalized older adults, malnutrition, post-discharge care, physical function, health-related quality of life, hospital readmission, length of hospital stay, mortality, nutritional status, energy and protein intake, weight loss, exercise training, home visits, telephone follow-up
- MeSH terms
- Functional Status, Aged, Counseling, Female, Humans, Length of Stay, Male, Nutritional Status, Patient Discharge, Patient Readmission, Quality of Life, Weight Loss, Geriatric Assessment, Single-Blind Method, Treatment Outcome, Subacute Care, Malnutrition, Nutrition Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
