Perinatal Cytomegalovirus and Varicella Zoster Virus Infections

Bialas, Kristy M.; Swamy, Geeta K.; Permar, Sallie R.

doi:10.1016/j.clp.2014.10.006

Cited by 54Cytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsNeonatal and Maternal Infections

Perinatal Cytomegalovirus and Varicella Zoster Virus Infections

Open access

Bialas, Kristy M., Swamy, Geeta K., Permar, Sallie R.·2015·Clinics in Perinatology

DOI 10.1016/j.clp.2014.10.006PMC PMC4328139

Open this paper in CoChat — free account

Abstract

Mother-to-child transmission of cytomegalovirus (CMV) and varicella zoster virus (VZV) can lead to severe birth defects and neurologic impairment of infants. Congenital CMV complicates up to 1% of all pregnancies globally. Although antiviral treatment of infants congenitally infected with CMV can ameliorate the CMV-associated hearing loss and developmental delay, interventions to prevent congenital CMV infection and the associated neurologic impairments are still being evaluated. Congenital VZV infection is rare. Active and passive immunization strategies to prevent perinatal CMV infection with similar efficacy to those established to prevent perinatal VZV infections are critically needed in pediatric health.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.clp.2014.10.006

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cytomegalovirus infection can lead to congenital disabilities and neurological impairment in infants.
“Cytomegalovirus infection, for example, causes complications in up to 1% of pregnancies and can lead to congenital disabilities and neurological impairment in infants220.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [220]
Cytomegalovirus infection causes complications in up to 1% of pregnancies.
“Cytomegalovirus infection, for example, causes complications in up to 1% of pregnancies and can lead to congenital disabilities and neurological impairment in infants220.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [220]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Infectious Diseases of the Fetus and Newborn Infant
Remington, J. S., & Klein, J. O. (1984) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198401000-00024 · Cited by 2,473 · see citing works
Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
Kenneson, A., & Cannon, M. J. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.535 · Cited by 1,723 · see citing works
Centers for Disease Control and Prevention (CDC) : Advisory Committee on Immunization Practices (ACIP) : Quadrivalent human papillomavirus vaccine : recommendations of the Advisory Committee on Immunization Practices (ACIP)
Le, M. (2007) · Medical Entomology and Zoology · Cited by 1,625 · see citing works
Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
Cannon, M. J., Schmid, D. S., & Hyde, T. B. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.655 · Cited by 1,495 · see citing works
New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection
Dollard, S. C., Grosse, S. D., & Ross, D. S. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.544 · Cited by 1,260 · see citing works
Prevention of Varicella: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
Marin, M., Güriş, D., Chaves, S. S., Schmid, S., & Seward, J. F. (1996) · PsycEXTRA Dataset · doi:10.1037/e547262006-001 · Cited by 1,077 · see citing works
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
Kimberlin, D. W., Lin, C., Sánchez, P. J., et al. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00192-6 · Cited by 987 · see citing works
Passive Immunization during Pregnancy for Congenital Cytomegalovirus Infection
Nigro, G., Adler, S. P., Torre, R. L., & Best, A. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043337 · Cited by 776 · see citing works
Vaccine Prevention of Maternal Cytomegalovirus Infection
Pass, R. F., Zhang, C., Evans, A., Simpson, T. Y., Andrews, W. J., Huang, M.-L. W., Corey, L., Hill, J., Davis, E., Flanigan, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804749 · Cited by 711 · see citing works
Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases
Enders, G., Bolley, I., Miller, E. J., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92943-2 · Cited by 698 · see citing works
Saliva Polymerase-Chain-Reaction Assay for Cytomegalovirus Screening in Newborns
Boppana, S. B., Ross, S. A., Shimamura, M., Palmer, A. L., Ahmed, A. I., Michaels, M. G., Sánchez, P. J., Bernstein, D. I., Tolan, R. W., Novák, Z., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1006561 · Cited by 491 · see citing works
A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus
Revello, M. G., Lazzarotto, T., Guerra, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1310214 · Cited by 491 · see citing works
Prevention of varicella : Recommendations of the Advisory Committee on Immunization Practices (ACIP).
Guris, Chaves, & Schmid (2007) · MMWR Morbidity and Mortality Weekly Report · Cited by 476 · see citing works
Outcome after Maternal Varicella Infection in the First 20 Weeks of Pregnancy
Pastuszak, A. L., Levy, M., Schick, B., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301305 · Cited by 441 · see citing works
Washing our hands of the congenital cytomegalovirus disease epidemic
Cannon, M. J., & Davis, K. F. (2005) · BMC Public Health · doi:10.1186/1471-2458-5-70 · Cited by 383 · see citing works
Dried Blood Spot Real-time Polymerase Chain Reaction Assays to Screen Newborns for Congenital Cytomegalovirus Infection
Boppana, S. B. (2010) · JAMA · doi:10.1001/jama.2010.423 · Cited by 383 · see citing works
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee
Modlin, J. F., Arvin, A. M., Fast, P., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/421999 · Cited by 333 · see citing works
Pharmacokinetic and Pharmacodynamic Assessment of Oral Valganciclovir in the Treatment of Symptomatic Congenital Cytomegalovirus Disease
Kimberlin, D. W., Acosta, E. P., Sánchez, P. J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/528376 · Cited by 307 · see citing works
New advances in the diagnosis of congenital cytomegalovirus infection
Lazzarotto, T., Guerra, B., Lanari, M., et al. (2007) · Journal of Clinical Virology · doi:10.1016/j.jcv.2007.10.015 · Cited by 297 · see citing works
DEVELOPMENT OF A VACCINE AGAINST MENTAL RETARDATION CAUSED BY CYTOMEGALOVIRUS INFECTION IN UTERO
Elek, S. D., & Stern, H. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92997-3 · Cited by 291 · see citing works
Attribution of Congenital Cytomegalovirus Infection to Primary Versus Non-Primary Maternal Infection
Wang, C., Zhang, X., Bialek, S., & Cannon, M. J. (2010) · Clinical Infectious Diseases · doi:10.1093/cid/ciq085 · Cited by 281 · see citing works
Immunity Induced By Primary Human Cytomegalovirus Infection Protects Against Secondary Infection Among Women Of Childbearing Age
Adler, S. P., Starr, S. E., Plotkin, S. A., et al. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.1.26 · Cited by 255 · see citing works
A Subunit Cytomegalovirus Vaccine Based on Recombinant Envelope Glycoprotein B and a New Adjuvant
Pass, R. F., Duliège, A., Boppana, S. B., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/315022 · Cited by 250 · see citing works
A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial
Kharfan‐Dabaja, M. A., Boeckh, M., Wilck, M. B., Langston, A. A., Chu, A. H., Wloch, M. K., Guterwill, D. F., Smith, L. R., Rolland, A. P., & Kenney, R. T. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70344-9 · Cited by 231 · see citing works
Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers
Bernstein, D. I., Reap, E. A., Katen, K., Watson, A., Smith, K., Norberg, P., Olmsted, R. A., Hoeper, A., Morris, J., Negri, S., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.09.135 · Cited by 212 · see citing works
Congenital cytomegalovirus infection: Outcome and diagnosis
Ross, S. A., & Boppana, S. B. (2005) · Seminars in Pediatric Infectious Diseases · doi:10.1053/j.spid.2004.09.011 · Cited by 211 · see citing works
Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants
Yow, M. D., Williamson, D., Leeds, L. J., et al. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90252-9 · Cited by 201 · see citing works
Cytomegalovirus transmission to preterm infants during lactation
Hamprecht, K., Maschmann, J., Jahn, G., et al. (2008) · Journal of Clinical Virology · doi:10.1016/j.jcv.2007.12.005 · Cited by 179 · see citing works
Clinical Trials of Immunization with the Towne 125 Strain of Human Cytomegalovirus
Plotkin, S. A., Farquhar, J. W., & Hornberger, E. (1976) · The Journal of Infectious Diseases · doi:10.1093/infdis/134.5.470 · Cited by 177 · see citing works
HCMV gH/gL/UL128–131 interferes with virus entry into epithelial cells: Evidence for cell type-specific receptors
Ryckman, B. J., Chase, M. C., & Johnson, D. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804365105 · Cited by 163 · see citing works
Detection of Congenital Cytomegalovirus Infection by Real-Time Polymerase Chain Reaction Analysis of Saliva or Urine Specimens
Ross, S. A., Ahmed, A. I., Palmer, A. L., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu263 · Cited by 149 · see citing works
Immunoglobulin M antibodies detected by enzyme-linked immunosorbent assay and radioimmunoassay in the diagnosis of cytomegalovirus infections in pregnant women and newborn infants
Stagno, S., Tinker, M. K., Elrod, C., et al. (1985) · Journal of Clinical Microbiology · doi:10.1128/jcm.21.6.930-935.1985 · Cited by 143 · see citing works
Safety and Immunogenicity of a Bivalent Cytomegalovirus DNA Vaccine in Healthy Adult Subjects
Wloch, M. K., Smith, L. R., Boutsaboualoy, S., Reyes, L., Han, C. S., Kehler, J., Smith, H. D., Selk, L., Nakamura, R., Brown, J. W., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/588385 · Cited by 139 · see citing works
Avidity of immunoglobulin G directed against human cytomegalovirus during primary and secondary infections in immunocompetent and immunocompromised subjects
Lazzarotto, T., Spezzacatena, P., Pradelli, P., et al. (1997) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.4.4.469-473.1997 · Cited by 139 · see citing works
A Canarypox Vector Expressing Cytomegalovirus (CMV) Glycoprotein B Primes for Antibody Responses to a Live Attenuated CMV Vaccine (Towne)
Adler, S. P., Plotkin, S. A., Gönczöl, É., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314951 · Cited by 126 · see citing works
Congenital cytomegalovirus infection: A long-standing problem still seeking a solution
HAGAY, Z. J., Biran, G., Ornoy, A., & Reece, E. A. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70401-5 · Cited by 125 · see citing works
Cytomegalovirus Infection in a Day-Care Center
Pass, R. F., August, A., DWORSKY, M. E., et al. (1982) · New England Journal of Medicine · doi:10.1056/nejm198208193070804 · Cited by 120 · see citing works
Live Cytomegalovirus Vaccination of Renal Transplant Candidates
Glazer, J., FRIEDMAN, H. M., GROSSMAN, R. A., et al. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-5-676 · Cited by 112 · see citing works
Cytomegalovirus prevalence in pregnant women: the influence of parity.
Tookey, P. A., Ades, A. E., & Peckham, C. S. (1992) · Archives of Disease in Childhood · doi:10.1136/adc.67.7_spec_no.779 · Cited by 111 · see citing works
Glycoprotein B Vaccine Is Capable of Boosting Both Antibody and CD4 T-Cell Responses to Cytomegalovirus in Chronically Infected Women
Sabbaj, S., Pass, R. F., Pichon, S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir138 · Cited by 111 · see citing works
Updated Recommendations for Use of VariZIG—United States, 2013
(2013) · American Journal of Transplantation · doi:10.1111/ajt.12477 · Cited by 101 · see citing works
Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers
Mitchell, D. K., Holmes, S. J., BURKE, R. L., et al. (2002) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200202000-00009 · Cited by 98 · see citing works
Safety and immunogenicity of the Towne strain cytomegalovirus vaccine
Adler, S. P., Hempfling, S., Starr, S. E., et al. (1998) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199803000-00006 · Cited by 88 · see citing works
Impact of diagnostic and confirmatory tests and prenatal counseling on the rate of pregnancy termination among women with positive cytomegalovirus immunoglobulin M antibody titers
Guerra, B., Simonazzi, G., Banfi, A., et al. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.08.039 · Cited by 83 · see citing works
Fetal and neonatal varicella-zoster infections.
Brunell, P. A. (1983) · PubMed · Cited by 79 · see citing works
Specific Cellular and Humoral Immunity after Immunization with Live Towne Strain Cytomegalovirus Vaccine
Starr, S. E., Glazer, J., Friedman, H. M., et al. (1981) · The Journal of Infectious Diseases · doi:10.1093/infdis/143.4.585 · Cited by 72 · see citing works
Transmission of cytomegalovirus to mothers by infected infants: another reason to prevent transfusion-acquired infections
Yeager, A. S. (1983) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198307000-00008 · Cited by 72 · see citing works
Vaccination against cytomegalovirus, the changeling demon
Plotkin, S. A. (1999) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199904000-00002 · Cited by 70 · see citing works
Human Milk and the Premature Infant
Bhatia, J. J. S. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000351537 · Cited by 69 · see citing works
Cytomegalovirus Infection
Plosa, E. J., Esbenshade, J. C., Fuller, M. P., et al. (2012) · Pediatrics in Review · doi:10.1542/pir.33-4-156 · Cited by 68 · see citing works
Breast milk-acquired cytomegalovirus infection in very low birth weight infants
Lombardi, G., Garofoli, F., Manzoni, P., et al. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.712345 · Cited by 58 · see citing works
Update on recommendations for use of VariZIG — United States, 2013
Marin, M., Bialek, S. R., & Seward, J. F. (2013) · Cited by 50 · see citing works
Vaccination of Pediatric Nurses With Live Attenuated Cytomegalovirus
FLEISHER, G. R. (1982) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1982.03970400012003 · Cited by 47 · see citing works
Antiviral prophylaxis and treatment in chickenpox
OGILVIE, M. M. (1998) · Journal of Infection · doi:10.1016/s0163-4453(98)80153-9 · Cited by 45 · see citing works
Management of chickenpox in the adult
Wilkins, E., Leen, C. L. S., McKendrick, M. W., et al. (1998) · Journal of Infection · doi:10.1016/s0163-4453(98)80155-2 · Cited by 44 · see citing works
Should We Routinely Screen for Cytomegalovirus Antibody during Pregnancy?
Grangeot‐Keros, L., Simon, B., Audibert, F., et al. (1998) · Intervirology · doi:10.1159/000024930 · Cited by 44 · see citing works
Updated recommendations for use of VariZIG--United States, 2013.
(2013) · PubMed · Cited by 40 · see citing works
Humoral Immune Response to Cytomegalovirus Towne Vaccine Strain and to Toledo Low-Passage Strain
Gönczöl, É., Ianacone, J., Furlini, G., et al. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/159.5.851 · Cited by 34 · see citing works
The cost-effectiveness of antenatal varicella screening with post-partum vaccination of susceptibles
de Moira, A. P., EDMUNDS, W., & Breuer, J. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.09.028 · Cited by 26 · see citing works
Management of the Presumed Susceptible Varicella (Chickenpox)-Enposed Gravida: A Cost-Effectiveness/Cost-Benefit Analysis
Rouse, D. J., GARDNER, M., Allen, S. J., et al. (1996) · Obstetrics and Gynecology · doi:10.1016/0029-7844(96)00025-7 · Cited by 25 · see citing works
Vaccination of pediatric nurses with live attenuated cytomegalovirus
(1983) · Journal of Infection · doi:10.1016/s0163-4453(83)93981-6 · Cited by 24 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[3]Britt W Cytomegalovirus Infectious disease of the fetues and newborn infant 2011 Philadelphia Elsevier Saunders 706

Sorted by citations

mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Contributions of maternal and fetal antiviral immunity in congenital disease
Yockey, L. J., Lucas, C., & Iwasaki, A. (2020) · Science · doi:10.1126/science.aaz1960 · Cited by 68 · see citing works

Therapeutic Approaches to Varicella-Zoster Virus Infections
Whitley, R. J. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.supplement_1.s51 · Cited by 65 · see citing works
Case of chickenpox in which varicella zoster virus genotype E was identified for the first time in Japan
Egawa, G., Egawa, K., & Kabashima, K. (2019) · The Journal of Dermatology · doi:10.1111/1346-8138.15153 · Cited by 8 · see citing works
EPID-06. QUANTIFYING THE POTENTIAL PUBLIC HEALTH IMPACT OF VARICELLA ZOSTER VIRUS (VZV) VACCINATION ON GLIOMA INCIDENCE
Shen, E., Wallace, A. R., Zhang, C., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa215.324
Human varicella zoster virus is not present in the semen of a man affected by chickenpox during the in vitro fertilisation of his wife
Chan, D. Y. L., Lam, K. K. W., Lau, E. Y. L., et al. (2017) · Andrologia · doi:10.1111/and.12822 · Cited by 1 · see citing works
Varicella Vaccine and Infection with Varicella–Zoster Virus
Vázquez, M., & Shapiro, E. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmp048320 · Cited by 70 · see citing works

Authors: Bialas, K. M., Swamy, G. K., & Permar, S. R.
Affiliations: Duke University (US)
Corresponding author: Permar, Sallie R.
ORCID: Swamy, Geeta K.
Permar, Sallie R.
Venue: Clinics in Perinatology
Publisher: Elsevier BV
Published: 2015-03
Volume: 42
Issue: 1
Pages: 61-75
ISSN: 0095-5108 (ISSN-L)
DOI: 10.1016/j.clp.2014.10.006
PMC: PMC4328139
OpenAlex: W77447462
Cited by: 54
References: 61
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 4 · 2017: 11 · 2016: 5 · 2015: 3
FWCI: 0.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinics in Perinatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (DP2HD075699)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords: congenital cytomegalovirus infection, mother-to-child transmission, perinatal infection, congenital malformations, neurological deficit, hearing loss, developmental delay, antiviral therapy, passive immunization, active immunization, congenital infection prevention
MeSH terms: Antiviral Agents, Chickenpox, Cytomegalovirus Infections, Female, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Complications, Infectious, Chickenpox Vaccine, Cytomegalovirus Vaccines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Perinatal Cytomegalovirus and Varicella Zoster Virus Infections

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks