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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
Open accessAbstract
Signaling cascades that control adipogenesis are essential in the regulation of body weight and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report here that p62(-/-) mice develop mature-onset obesity, leptin resistance, as well as impaired glucose and insulin intolerance. The metabolic rate was significantly reduced in p62(-/-) nonobese mice, which displayed increased mRNA levels of PPAR-gamma and reduced levels of UCP-1 in adipose tissue. Basal activity of ERK was enhanced in fat from nonobese mutant mice. Embryo fibroblasts from p62(-/-) mice differentiated better than the wild-type controls into adipocytes, which was abrogated by pharmacological inhibition of the ERK pathway. p62 is induced during adipocyte differentiation and inhibits ERK activation by direct interaction. We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity.
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“sqstm1-knockout mice display reduced numbers of osteoclasts as well as cognitive impairment and anxiety, associated with hyperphosphorylated MAPT/tau and neurofibrillary tangles [134–136].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [136]
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Balasubramanyam, M., Lenin, R. R., & Monickaraj, F. (2010) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-010-0022-1 · Cited by 15
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Ohtsuka, S., Ishii, Y., Matsuyama, M., Ano, S., Morishima, Y., Yanagawa, T., Warabi, E., & Hizawa, N. (2013) · European Journal of Immunology · doi:10.1002/eji.201344091 · Cited by 14
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Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction
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Spartin recruits PKC‐ζ via the PKC‐ζ‐interacting proteins ZIP1 and ZIP3 to lipid droplets
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“A recent study [83] illustrated that mice with a genetic ablation of p62, a scaffold protein that serves to locate aPKC in selective signaling pathways [84], exhibit mature-onset obesity and insulin resistance.”
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P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1
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Keller, C., Yorgan, T. A., Rading, S., Schinke, T., & Karsak, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.858215 · Cited by 5
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“A previous study demonstrated that p62 inhibits adipocyte differentiation at early stages by blocking the basal ERK activity (Rodriguez et al., 2006).”
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MACROPHAGE AUTOPHAGY IN IMMUNE RESPONSE
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Autophagy and Lipid Metabolism in Cardiometabolic Diseases
Yang, M., Zhang, Y., & Ren, J. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00011-0
Studies on Differentiation Mechanisms of Epithelial Cells in the Digestive System
杉山, 昌., & Sugiyama, M. (2018) · Institutional Repositories DataBase (IRDB) · doi:10.15068/00152275
Zhang, W., & He, C. (2014) · Autophagy · doi:10.4161/auto.28149
RetractedMoscat, J., & Díaz-Meco, M. T. (2006) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a003917.01
Self-citationFeng, J., Li, Y., Zhang, Y., Sun, S., Sun, J., Xu, Q., Ji, X., Liu, Y., & Wan, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26681746
Vella, R. (2013) · theses.fr (ABES) · doi:10.70675/5d6d7be0z4be0z4763z94a7z7426da9a6eb3
Rôle de l'autophagie macrophagique dans la maladie alcoolique du foie et la fibrose hépatique
Denaës, T. (2015) · theses.fr (ABES) · doi:10.70675/9da282e2zf867z4eb6zabe3z04aecf04b096
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice
Keller, C., Rading, S., Candur, B., Bîndilă, L., Loers, G., & Karsak, M. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102571
“Several studies have revealed that p62 deficiency leads to the development of obesity, insulin resistance, and leptin intolerance in mice, establishing a critical role for p62 in the regulation of energy balance [34,35].”
de Calbiac, H. (2019) · theses.fr (ABES) · doi:10.70675/bafe951fz8332z4b0azb55bzac8a4af1955b
Kim, D., Salazar, G., Klemp, A., Hwang, H., Yeh, M., Panton, L. B., & Kim, J. (2026) · Physiological Reports · doi:10.14814/phy2.70851
“Pioneering studies demonstrated that mice lacking the p62 gene develop mature-onset obesity accompanied by systemic glucose intolerance and insulin resistance (Hiruma et al., 2008; Rodriguez et al., 2006).”
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Rantanen, K. (2012) · UTUPub (University of Turku)
Cabré, L. R. (2012) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Metadata
- Authors
- Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J.
- Affiliations
- Phénotypage et ingénierie précliniques des systèmes d’organismes modèles (FR)
- Universidad Complutense de Madrid (ES)
- Spanish National Cancer Research Centre (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Moscat, Jorge
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 3
- Issue
- 3
- Pages
- 211-222
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2096738869
- Cited by
- 290
- References
- 34
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 19 · 2020: 14 · 2019: 14 · 2018: 24 · 2017: 17 · 2016: 19 · 2015: 14 · 2014: 22 · 2013: 26 · 2012: 21
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- p62, insulin resistance, leptin resistance, adipogenesis, ERK signaling, PPARγ, UCP1, metabolic rate, adipose tissue, impaired glucose tolerance
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Embryo, Mammalian, Fibroblasts, HeLa Cells, Humans, Insulin Resistance, RNA, Messenger, Transcription Factors, Signal Transduction, Adipocytes, Mice, Knockout, 3T3-L1 Cells, Extracellular Signal-Regulated MAP Kinases, Adipogenesis, Mice, Transcription Factor TFIIH
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