The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
Open accessAbstract
The NAD(+)-dependent deacetylase SIRT1 controls metabolic processes in response to low nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action on AMPK. SRT1720 administration robustly enhances endurance running performance and strongly protects from diet-induced obesity and insulin resistance by enhancing oxidative metabolism in skeletal muscle, liver, and brown adipose tissue. These metabolic effects of SRT1720 are mediated by the induction of a genetic network controlling fatty acid oxidation through a multifaceted mechanism that involves the direct deacetylation of PGC-1alpha, FOXO1, and p53 and the indirect stimulation of AMPK signaling through a global metabolic adaptation mimicking low energy levels. Combined with our previous work on resveratrol, the current study further validates SIRT1 as a target for the treatment of metabolic disorders and characterizes the mechanisms underlying the therapeutic potential of SIRT1 activation.
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“In the cases of resveratrol and the sirtuin activator SRT1720, there is convincing evidence that they protect from metabolic damage and improve mitochondrial respiration in a PGC-1α-dependent fashion”
From The Hallmarks of Aging (2013) · cites this paper as Feige et al., 2008
In the citing paper
“However, SRT1720 has been shown in BAT to modify lipid droplet size and gene expression 157,158.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [158]
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Cites
Current protocols in molecular biology
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Self-citationNutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943
Sirtuins in mammals: insights into their biological function
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
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Tulp, O. L. (2024) · Endocrinology&Metabolism International Journal · doi:10.15406/emij.2024.12.00359
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Tulp, O. L. (2025) · Gastroenterology & Hepatology Open Access · doi:10.15406/ghoa.2025.16.00603
Nobarı, H., Parnian-Khajehdizaj, N., & Fleming, A. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106980
Genome-scale modeling reveals regulation of human metabolism by the histone deacetylase SIRT1Preprint
Pi, J. R., Alberto, J., Paoli, J., Baspinar, O., Guéant‐Rodriguez, R., Guéant, J., & Heinken, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.03.673976
任, 佳. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113194
Origen neonatal de la síndrome metabòlica en l'adult
Pentinat, T. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Herrera, C. L. (2015) · theses.fr (ABES) · doi:10.70675/d09d7e9cz079fz4faaz985aza9cd4fc18f18
Khatib, N. E. (2016) · theses.fr (ABES) · doi:10.70675/2950e899zef27z47bdza1cezb2a10051ff2b
Translating Resveratrol Research: A Systematic Review on Patents and Clinical Trials (2000–2025)
Kaurav, M., Ghai, R., Pal, N., & Nagarajan, K. (2026) · The Open Biotechnology Journal · doi:10.2174/0118740707407791260409045456
Liu, S., Gao, Q., Zhang, J. C., Zhang, Q., Elsharkawy, M. S., Wang, J., Wang, X., Su, M., Song, D., Wen, J., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202503595r
Sirtuin modulators: small molecules and natural compounds
Dubey, R., & Prabhakar, P. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45380-9.00004-3
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Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins
Trivedi, K., & Dolinsky, V. W. (2026) · Pharmaceuticals · doi:10.3390/ph19101557
ZnO Q-Dots Nanoparticles: Intensifying ROS Stress to Improve Anticancer Drug Efficacy
Bashash, D., Salahi‐Niri, A., Fakhroueian, Z., & Esmaeili, S. (2026) · International Journal of Cancer Management · doi:10.5812/ijcm-166395
BindingDB (2018) · UC San Diego · doi:10.7270/q2vh5qtw
BindingDB (2013) · UC San Diego · doi:10.7270/q25x2b28
Bruss, M. D. (2011) · eScholarship (California Digital Library)
Metadata
- Authors
- Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Auwerx, Johan
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 8
- Issue
- 5
- Pages
- 347-358
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2077834313
- Cited by
- 719
- References
- 39
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 19 · 2023: 22 · 2022: 22 · 2021: 30 · 2020: 29 · 2019: 28 · 2018: 42 · 2017: 28 · 2016: 41 · 2015: 51 · 2014: 58 · 2013: 64 · 2012: 63
- FWCI
- 27.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- SIRT1, SRT1720, NAD+-dependent deacetylase, fatty acid oxidation, diet-induced obesity, insulin resistance, AMPK signaling, PGC-1α, FOXO1, p53, brown adipose tissue, skeletal muscle metabolism, hepatic metabolism, endurance running performance, low energy availability, metabolic adaptation, resveratrol, metabolic disorders
- MeSH terms
- Acetylation, Animals, Diet, Dietary Fats, Energy Metabolism, Heterocyclic Compounds, 4 or More Rings, Insulin Resistance, Male, Metabolic Diseases, Mice, Inbred C57BL, Motor Activity, Obesity, Oxidation-Reduction, Physical Conditioning, Animal, Sirtuins, Lipid Metabolism, Mice, Sirtuin 1
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