Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

Current protocols in molecular biology

Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943

Sirtuins in mammals: insights into their biological function

Michán, S., & Sinclair, D. A. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,750

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

Lakshminarasimhan, M., Curth, U., Moniot, S., Mosalaganti, S., Raunser, S., & Steegborn, C. (2013) · Bioscience Reports · doi:10.1042/bsr20120121 · Cited by 39

Acetylation and insulin resistance: a focus on metabolic and mitogenic cascades of insulin signaling

Emamgholipour, S., Ebrahimi, R., Bahiraee, A., Niazpour, F., & Meshkani, R. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1699498 · Cited by 40

Ligand and structure-based approaches for the identification of SIRT1 activators

Vyas, V. K., Goel, A., Ghate, M. D., & Patel, P. N. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.01.001 · Cited by 36

AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease

Vilà, L., Elias, I., Roca, C., Ribera, A., Ferré, T., Casellas, A., Lage, R., Franckhauser, S., & Bosch, F. (2014) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2014.39 · Cited by 34

SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression

Feng, T., Liu, P., Wang, X., Luo, J., Zuo, X., Jiang, X., Liu, C., Li, Y., Li, N., Chen, M., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.04.039 · Cited by 35

Metabolic mechanisms orchestrated by Sirtuin family to modulate inflammatory responses

Li, X., Li, Y., Hao, Q., Jin, J., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1448535 · Cited by 37

Resveratrol derivatives: a patent review (2009 – 2012)

Pezzuto, J. M., Kondratyuk, T. P., & Ogas, T. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.834888 · Cited by 36

Sirtuins and Pyridine Nucleotides

Abdellatif, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.246546 · Cited by 35

HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells

Fang, M., Fan, Z., Tian, W., Zhao, Y., Li, P., Xu, H., Zhou, B., Zhang, L., Wu, X., & Xu, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.11.010 · Cited by 35

Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism

Karwi, Q. G., Joerg, A. R., & Lopaschuk, G. D. (2019) · Biochemical Journal · doi:10.1042/bcj20180617 · Cited by 38

Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity

Hughes-Large, J. M., Pang, D., Robson, D. L., Chan, P., Toma, J., & Borradaile, N. M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.090 · Cited by 35

Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema

Gu, C., Li, Y., Xu, W., Yan, J., Xia, Y., Ma, Y., Chen, C., Wang, H., & Tao, H. (2014) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2014.974740 · Cited by 34

Sirtuin 1 Modulation in Rat Model of Acetaminophen-Induced Hepatotoxicity

WOJNAROVÁ, L., Canová, N. K., Farghali, H., & Kučera, T. (2015) · Physiological Research · doi:10.33549/physiolres.933205 · Cited by 34

Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity

Stefanowicz, M., Nikołajuk, A., Matulewicz, N., & Karczewska‐Kupczewska, M. (2018) · Endocrine · doi:10.1007/s12020-018-1544-1 · Cited by 34

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

Yang, F., Huang, P., Shi, L., Liu, F., Tang, A., & Xu, S. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s258857 · Cited by 37

Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway

Feng, B., Huang, B., Jing, Y., Shen, S., Feng, W., Wang, W., Meng, R., & Zhu, D. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110023 · Cited by 34

GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity

Jeon, J., Choi, S., Ha, E., Lee, H., Kim, T., Han, S., Kim, H., Kim, D., Kang, Y., & Lee, K. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4272 · Cited by 33

Histone Modifications in NAFLD: Mechanisms and Potential Therapy

Shi, Y., & Qi, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914653 · Cited by 34

Disorders of Lipid Metabolism and Chronic Kidney Disease in the Elderly

Choudhury, D., Tuncel, M., & Levi, M. (2009) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2009.07.006 · Cited by 36

Dynamic mobilization of PGC-1α mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation

Chen, S., Fan, Q., Li, A., Liao, D., Ge, J., Laties, A. M., & Zhang, X. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0837-3 · Cited by 34

Molecular mechanisms of fatty liver in obesity

Gan, L., Xiang, W., Xie, B., & Yu, L. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0410-2 · Cited by 37

Advanced Glycation End Products Induce Endothelial-to-Mesenchymal Transition via Downregulating Sirt 1 and Upregulating TGF-βin Human Endothelial Cells

He, W., Zhang, J., Gan, T., Xu, G., & Tang, B. (2015) · BioMed Research International · doi:10.1155/2015/684242 · Cited by 33

Diabetes Mellitus, Inflammation, Obesity: Proposed Treatment Pathways for Current and Future Therapies

Sonnett, T. E., Levien, T. L., Gates, B. J., Robinson, J. D., & Campbell, R. K. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1m640 · Cited by 32

Resveratrol treatment reduces the appearance of tubular aggregates and improves the resistance to fatigue in aging mice skeletal muscles

Toniolo, L., Fusco, P., Formoso, L., Mazzi, A., Canato, M., Reggiani, C., & Giacomello, E. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.012 · Cited by 34

Pharmacological induction of mitochondrial biogenesis as a therapeutic strategy for the treatment of type 2 diabetes

Zamora, M., Pardo, R., & Villena, J. A. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.032 · Cited by 32

SRT1720 Induces Lysosomal-Dependent Cell Death of Breast Cancer Cells

Lahusen, T. J., & Deng, C. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0584 · Cited by 32

Energetic cell sensors: a key to metabolic homeostasis

Naïmi, M., Arous, C., & OBBERGHEN, E. V. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.09.003 · Cited by 30

Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis

Avilkina, V., Chauveau, C., & Mhenni, O. G. (2021) · Bone · doi:10.1016/j.bone.2021.116232 · Cited by 33

Platelets in Non-alcoholic Fatty Liver Disease

Dalbeni, A., Castelli, M., Zoncapè, M., Minuz, P., & Sacerdoti, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.842636 · Cited by 33

Sirtuin Modulators

Mahajan, S. S., Leko, V., Simon, J. A., & Bedalov, A. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_11 · Cited by 32

The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Yamagata, K., Mizumoto, T., & Yoshizawa, T. (2023) · Cells · doi:10.3390/cells13010048 · Cited by 33

Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery

Kim, G.-W., Gocevski, G., Wu, C.-J., & Yang, X. (2010) · International Journal of Cell Biology · doi:10.1155/2010/632739 · Cited by 34

Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Sun, L., Fan, Z., Chen, J., Tian, W., Li, M., Xu, H., Wu, X., Shao, J., Bian, Y., Fang, M., et al. (2016) · Scientific Reports · doi:10.1038/srep28432 · Cited by 30

Reversal of Defective Mitochondrial Biogenesis in Limb-Girdle Muscular Dystrophy 2D by Independent Modulation of Histone and PGC-1α Acetylation

Pambianco, S., Giovarelli, M., Perrotta, C., Zecchini, S., Cervia, D., Renzo, I. D., Moscheni, C., Ripolone, M., Violano, R., Moggio, M. G., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.044 · Cited by 30

Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca2+

Song, S. B., Park, J., Jang, S. Y., & Hwang, E. S. (2021) · Cells · doi:10.3390/cells10030612 · Cited by 31

Sirt1 coordinates with ERα to regulate autophagy and adiposity

Tao, Z., Shi, L., Parke, J., Zheng, L., Gu, W. J., Dong, X. C., Liu, D., Wang, Z., Olumi, A. F., & Cheng, Z. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00438-8 · Cited by 32

Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet

Cao, Z., Ma, B., Cui, C., Zhao, J., Liu, S., Qiu, Y., Zheng, Y., Gao, M., & Luan, X. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101708 · Cited by 30

Therapeutic Antiaging Strategies

Mishra, S. K., Balendra, V., Esposto, J., Obaid, A. A., Maccioni, R. B., Jha, N. K., Perry, G. L., Moustafa, M., Al-Shehri, M., Singh, M. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102515 · Cited by 34

Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects

Rohrbach, S., Aslam, M., Niemann, B., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12650 · Cited by 31

Chitooligosaccharide Induces Mitochondrial Biogenesis and Increases Exercise Endurance through the Activation of Sirt1 and AMPK in Rats

Jeong, H. W., Cho, S. Y., Kim, S., Shin, E. S., Kim, J. M., Song, M. J., Park, P. J., Sohn, J. H., Park, H., Seo, D.-B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040073 · Cited by 30

Autophagy in the liver: cell’s cannibalism and beyond

Flores‐Toro, J., Go, K. L., Leeuwenburgh, C., & Js, K. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0807-8 · Cited by 30

Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats

Farage, A. E., Abdo, W. S., Osman, A., Abdel‐Kareem, M. A., Hakami, Z. H., Alsulimani, A., Bin‐Ammar, A., Alanazi, A. S., Alsuwayt, B., Alanazi, M. M., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121688 · Cited by 29

Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase Inhibition

Gueguen, C., Palmier, B., Plotkine, M., Marchand‐Leroux, C., & Besson, V. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087367 · Cited by 31

Novel PPAR Pan Agonist, ZBH Ameliorates Hyperlipidemia and Insulin Resistance in High Fat Diet Induced Hyperlipidemic Hamster

Chen, W., Fan, S., Xie, X., Xue, N., Jin, X., & Wang, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096056 · Cited by 29

A patent review of sirtuin activators: an update

Villalba, J. M., de Cabo, R., & Alcain, F. J. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.669374 · Cited by 29

Disuse-induced insulin resistance susceptibility coincides with a dysregulated skeletal muscle metabolic transcriptome

Mahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Stubben, C., Howard, M. T., & Drummond, M. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01093.2018 · Cited by 29

Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats

Lee, Y., Lee, J., Lee, M.-S., Chang, E., & Kim, Y. (2021) · Nutrients · doi:10.3390/nu13103660 · Cited by 31

Annual banned‐substance review: analytical approaches in human sports drug testing

Thevis, M., Kuuranne, T., Geyer, H., & Schänzer, W. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1441 · Cited by 30

Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity

Torma, F., Koltai, E., Nagy, E., Ziaaldini, M. M., Pósa, A., Koch, L. G., Britton, S. L., Boldogh, I. R., & Radak, Z. O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114075 · Cited by 29

Sirtuin biology and relevance to diabetes treatment

Dong, X. C. (2012) · Diabetes Management · doi:10.2217/dmt.12.16 · Cited by 29

Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism

Zhang, L., Yao, W., Xia, J., Wang, T., & Huang, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081885 · Cited by 30

Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects

Zhang, A., Wang, J., Zhao, Y., He, Y., & Sun, N. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1485632 · Cited by 31

Transcriptional Regulation of Metabolism by SIRT1 and SIRT7

Yamagata, K., & Yoshizawa, T. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.009 · Cited by 30

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

Karaman, B., Alhalabi, Z., Swyter, S., Mihigo, S. O., Andrae‐Marobela, K., Jung, M., Sippl, W., & Ntie‐Kang, F. (2018) · Molecules · doi:10.3390/molecules23020416 · Cited by 28

Ubiquitin C‐terminal hydrolase‐L3‐knockout mice are resistant to diet‐induced obesity and show increased activation of AMP‐activated protein kinase in skeletal muscle

Setsuie, R., Suzuki, M., Kabuta, T., Fujita, H., Miura, S., Ichihara, N., Yamada, D., Wang, Y., Ezaki, O., Suzuki, Y., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-132217 · Cited by 28

Calorie restriction prevents diet‐induced insulin resistance independently of PGC‐1‐driven mitochondrial biogenesis in white adipose tissue

Pardo, R., Vilà, M., Cervela, L., de Marco, M., Gama-Pérez, P., González-Franquesa, A., Statuto, L., Vilallonga, R., Simó, R., Garcia-Roves, P. M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201800310r · Cited by 27

Microbial diversity and fitness in the gut–brain axis: influences on developmental risk for Alzheimer’s disease

Jamerlan, A., An, S. S. A., & Hulme, J. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2486518 · Cited by 34

Hydrogel-based engineering of beige adipose tissue

Vaicik, M. K., Morse, M. C., Blagajcevic, A., Rios, J., Larson, J. C., Yang, F., Cohen, R., Papavasiliou, G., & Brey, E. M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00952a · Cited by 29

Gene expression profiles in the intestine of lipopolysaccharide-challenged piglets

Hou, Y. (2015) · Frontiers in bioscience · doi:10.2741/4404 · Cited by 27

Dual-edged role of SIRT1 in energy metabolism and cardiovascular disease

Zhou, R., Barnes, K., Gibson, S., & Fillmore, N. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00001.2024 · Cited by 29

Unlocking the secrets: Adipose tissue dysfunction and atherosclerosis-mechanisms and innovative therapeutic approaches

Matar, D. B., Elahi, M. A., Sukkarieh, H. H., Nassar, W. K., & Aljada, A. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120424 · Cited by 27

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Gomes, P., Leal, H., Mendes, A. F., Reis, F., & Cavadas, C. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.09.003 · Cited by 27

Emerging role of GCN5 in human diseases and its therapeutic potential

Xiao, H., Jin, J., & Zheng, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114835 · Cited by 26

Targeting mitochondrial alterations to prevent type 2 diabetes— E vidence from studies of dietary redox‐active compounds

Cheng, Z., Schmelz, E. M., Liu, D., & Hulver, M. W. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300747 · Cited by 26

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)

Svensson, K., Schnyder, S., Albert, V., Cardel, B., Quagliata, L., Terracciano, L., & Handschin, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590653 · Cited by 26

The Regulation of Insulin-Stimulated Cardiac Glucose Transport via Protein Acetylation

Renguet, E., Bultot, L., Beauloye, C., Horman, S., & Bertrand, L. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00070 · Cited by 26

SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation

Wu, S. Y., Liang, J., Yang, B. C., & Leung, P. S. (2019) · Stem Cells · doi:10.1002/stem.3073 · Cited by 28

Targeting prohibited substances in doping control blood samples by means of chromatographic–mass spectrometric methods

Thevis, M., Thomas, A., & Schänzer, W. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7224-3 · Cited by 25

SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual subsarcolemmal and intermyofibrillar mitochondria

Zhang, H., Qin, G.-J., Li, X., Zhang, Y., Du, P., Zhang, P.-Y., Zhao, Y., & Wu, J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0396-x · Cited by 25

The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity

Namwanje, M., Liu, L., Chan, M., Aaron, N., Kraakman, M. J., & Qiang, L. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0361 · Cited by 25

DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model

Luo, X. M., He, Z., Sun, X., Gu, X., Zhang, W., Gao, J., Li, X., Jia, R., Wei, J., Yu, Y., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s232279 · Cited by 25

Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA‐Seq

Huang, M., Xu, S., Li, Y., Li, S., Zhan, X., Qin, C., Su, J., Zhao, Z., He, Y., Qin, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202205525 · Cited by 25

Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions

Yu, X., Li, S., Wang, X., Zhao, B., Chen, S., Jiang, Q., Xu, S., & Li, S. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109000 · Cited by 25

Clinical physiology of NAFLD: a critical overview of pathogenesis and treatment

Lonardo, A., Caldwell, S. H., & Loria, P. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.5 · Cited by 25

Molecular cloning and characterization of porcine sirtuin genes

Jin, D., Tan, H., Lei, T., Gan, L., Chen, X., Long, Q., Feng, B., & Yang, Z. (2009) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2009.04.004 · Cited by 25

The role of sirtuins in the regulation of metabolic homeostasis in skeletal muscle

Ryall, J. G. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283590914 · Cited by 24

SREBPs: regulators of cholesterol/lipids as therapeutic targets in metabolic disorders, cancers and viral diseases

Walker, A. K., & Näär, A. M. (2012) · Clinical Lipidology · doi:10.2217/clp.11.67 · Cited by 25

Inhibition of de novo ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes

Velagapudi, S., Karsai, G., Karsai, M., Mohammed, S. A., Montecucco, F., Liberale, L., Lee, H., Carbone, F., Adami, G. F., Yang, K., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae100 · Cited by 24

Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications

Wang, Z., Yuan, S., Li, Y., Zhang, Z., Xiao, W. L., Tang, D., Ye, K., Liu, Z., Wang, C., Zheng, Y., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.034 · Cited by 24

Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise

Gurd, B. J., & Williams, C. (2012) · The Application of Clinical Genetics · doi:10.2147/tacg.s31276 · Cited by 24

Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice

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Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism

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Molecular Cloning and Characterization of Sirtuin 1 and Its Potential Regulation of Lipid Metabolism and Antioxidant Response in Largemouth Bass (Micropterus salmoides)

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Tang-Nai-Kang Alleviates Pre-diabetes and Metabolic Disorders and Induces a Gene Expression Switch toward Fatty Acid Oxidation in SHR.Cg-Leprcp/NDmcr Rats

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Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1

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Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia

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Skeletal Muscle Growth Hormone Receptor Signaling Regulates Basal, but Not Fasting-Induced, Lipid Oxidation

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Aging and Cancer: Are Sirtuins the Link?

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Mass spectrometric studies on the in vivo metabolism and excretion of SIRT1 activating drugs in rat urine, dried blood spots, and plasma samples for doping control purposes

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A label-free Sirtuin 1 assay based on droplet-electrospray ionization mass spectrometry

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Reproductive Experience may Positively Adjust the Trajectory of Senescence

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Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis

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Annual banned‐substance review: analytical approaches in human sports drug testing

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Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes

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Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?

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Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice

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Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice

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The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study

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SIRT1 in Metabolic Health and Disease

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Silencing Metabolic Disorders by Novel SIRT1 Activators

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Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

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