The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

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Synchronization of the circadian rhythm generator and the effects of glucagon on hypothalamic mouse neurons detected by acoustic wave propagation

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Nutrients and Liver Metabolism

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Can Avicenna Help Manage the Diabetes Epidemic in Central Asia?

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Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice

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Application of RNA interference to improve mechanistic understanding of omics responses to a hepatotoxic drug in primary rat hepatocytes

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Rôle du glucagon dans la physiopathologie et le traitement du diabète

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Impact of kelp and fucoidan on lipid metabolism in large yellow croaker (Larimichthys crocea)

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Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences

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Impact of moderate dietary protein restriction on glucose homeostasis in a model of estrogen deficiency

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An integrative view on glucagon function and putative role in the progression of pancreatic neuroendocrine tumours (pNETs) and hepatocellular carcinomas (HCC)

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Pancreatic Hormones

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Transcriptomic profile of longissimus thoracis associated with fatty acid content in Nellore beef cattle

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Novel approaches to treating type 2 diabetes

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Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance

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Increase in PUFA and protein, and decrease in carbohydrate intake improves liver fat in 12 months and the role of weight loss as a mediator: A randomized controlled trial

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Effect of short-term administration of glucagon on gene expression of the insulin receptor in primary cultured calf hepatocytes.

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Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH ‐promoting GAN diet and a high‐fat diet

Galsgaard, K. D., Elmelund, E., Hunt, J. E., Smits, M. M., Grevengoed, T. J., Christoffersen, C., Færgeman, N. J., Havelund, J. F., Albrechtsen, N. J. W., & Holst, J. J. (2025) · Physiological Reports · doi:10.14814/phy2.70235 · Cited by 2

Where are we now? Biased signalling of Class B G protein-coupled receptor-targeted therapeutics

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ATP8B1 Deficiency Causes Phosphodiesterase 4‐Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver

Chang, J., Panhuis, W. I. H., Hsu, S., Duijst, S., Mok, K. S., van der Heiden, J. F., Ying, Z., Erdmann, J. I., Vogel, G. F., Junge, N., et al. (2025) · Liver International · doi:10.1111/liv.70306 · Cited by 2

Role of enterocytes in dyslipidemia of insulin-resistant states

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Glucagon and the Glucagon-Like Peptides

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Glucagon and the metabolic syndrome

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Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1

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Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment

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GLP-1 Is Not Enough: Can Glucagon Fill the Energy Expenditure Gap?

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Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

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Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

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Ultrafiltered Mulberry (Morus alba L.) Leaf Albumin-Type Protein Attenuates High-Fat Diet-Induced Obesity in Mice by Remodeling Gut Microbiota and Metabolic Homeostasis

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Lower glucagon response and attenuated hepatic glucagon signaling in MASLD

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Rol del enterocito en la dislipemia de la resistencia insulínica

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Targeting the AMP-regulated kinase family to treat diabetes: a research update

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The antianginal ranolazine fails to improve glycaemia in obese liver‐specific pyruvate dehydrogenase deficient male mice

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Exploring the modulatory effects of sotagliflozin on dyslipidemia in mice: The role of glucagon, fibroblast growth factor 21 and glucagon‐like peptide 1

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Endocrine System Related to Diabetes Mellitus

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AMPK: Central Regulator of Glucose and Lipid Metabolism

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Glucagon in Islet and Metabolic Regulation

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Regulations of catabolic and anabolic mechanisms; the interactions between exercise, carbohydrates and an excessive intake of amino acids : A review of some of the metabolic pathways that affects the homeostasis of the body, as well as β-oxidation and protein synthesis

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Short title: A Role of VASP on hepatic fatty acid oxidation

Tateya, S., Rizzo, N. O., Handa, P., Cheng, A. M., Morgan‐Stevenson, V., Ogimoto, K., Kanter, J. E., Bornfeldt, K., Daum, G., Clowes, A. W., et al. (2013)

The Effect of Insulin and Insulin Resistance on Glucagon-like Peptide-1 Secretion from the Intestinal L Cell

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The preproglucagon derived peptides and energy homeostasis

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The Acute Regulation of Intestinal Chylomicron Secretion by Glucagon-like Peptides

Hsieh, J. (2012) · TSpace (University of Toronto)

The role of gut hormones on food intake and carbohydrate tolerance

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The development of gut hormones as drugs for the treatment of obesity

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Glucagon action in the dorsal vagal complex and the regulation of glucose homeostasis during high-protein feeding

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The metabolic effects of leptin therapy and glucagon suppression therapy in mouse models of diabetes

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Coordinate control of metabolic flux with liver energy status by AMPK in vivo

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New approaches to improve prediction of drug-induced liver injury

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Glucagon receptor is required for long-term survival: A natural history study of the Mahvash disease in a murine model

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Faculty Opinions recommendation of Regulation of hepatic glucose metabolism in health and disease.

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Efecto de la restricción calórica sobre la conducta sexual masculina, la calidad espermática y las hormonas metabólicas en la rata Wistar longeva

de Jesús, P. L. (2023) · doi:10.24275/uami.pc289j378

The central role of mitochondrial health in malnutrition induced enterohepatic dysfunction

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Novel insights into the physiological functions of glucagon

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Glucagon in Islet and Metabolic Regulation

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Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female micePreprint

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Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon

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Additional file 1 of Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Yang, J., MacDougall, M. L., McDowell, M. T., Xi, L., Wei, R., Zavadoski, W. J., Molloy, M. P., Baker, J. D., Kuhn, M., Cabrera, O., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12874143

Additional file 4 of Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Yang, J., MacDougall, M. L., McDowell, M. T., Xi, L., Wei, R., Zavadoski, W. J., Molloy, M. P., Baker, J. D., Kuhn, M., Cabrera, O., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12874152

Additional file 2 of Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Yang, J., MacDougall, M. L., McDowell, M. T., Xi, L., Wei, R., Zavadoski, W. J., Molloy, M. P., Baker, J. D., Kuhn, M., Cabrera, O., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12874146

Additional file 3 of Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Yang, J., MacDougall, M. L., McDowell, M. T., Xi, L., Wei, R., Zavadoski, W. J., Molloy, M. P., Baker, J. D., Kuhn, M., Cabrera, O., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12874149

Distinct and complementary metabolic effects of GLP-1 and glucagon receptor agonism in diet-induced obese mice

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Uncoupling Insulin Sensitivity From Longevity: A Sex‐Dependent Effect of Hepatic Glucagon Signaling

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Mécanismes moléculaires régulant l'action du glucagon-like peptide one dans la physiopathologie du diabète de type 2

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Rôle de RelB et de sa phosphorylation sur la sérine 472 dans les dérégulations du métabolisme in vitro et in vivo

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Postprandial Glucagon Action in the Human Brain

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Targeting glucagon signaling in metabolic disorders, functional insights from zebrafish receptor knockouts

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Glucagon Synthesis, Secretion, and Mechanisms of Action

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Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling

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Adrenal hormones in the maintenance of glucose homeostasis during prolonged fasting in male glucagon‐deficient mice

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Cell Metabolism Article The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

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GPR109a Signaling Alters the Hepatic Response to Fasting

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Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

Nason, S. R., Kim, T., ANTIPENKO, J. P., Finan, B., DiMarchi, R. D., Hunter, C. S., & Habegger, K. M. (2019) · Endocrinology · doi:10.1210/endocr/bqz013 · Cited by 25

Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH ‐promoting GAN diet and a high‐fat diet

Galsgaard, K. D., Elmelund, E., Hunt, J. E., Smits, M. M., Grevengoed, T. J., Christoffersen, C., Færgeman, N. J., Havelund, J. F., Albrechtsen, N. J. W., & Holst, J. J. (2025) · Physiological Reports · doi:10.14814/phy2.70235 · Cited by 2

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

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