The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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Sorting out the roles of PPAR in energy metabolism and vascular homeostasis

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Glucagon and regulation of glucose metabolism

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Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

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ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

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International Union of Pharmacology. XXXV. The Glucagon Receptor Family

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Expression cloning and signaling properties of the rat glucagon receptor

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New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes—Beyond and within GLP-1 Receptor Agonists

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Hepatic p38α regulates gluconeogenesis by suppressing AMPK

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Glucagon and Cyclic AMP: Time to Turn the Page?

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Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism

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Insights into incretin-based therapies for treatment of diabetic dyslipidemia

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The Vicious Circle of Hepatic Glucagon Resistance in Non-Alcoholic Fatty Liver Disease

Galsgaard, K. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124049 · Cited by 40

Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte

Habegger, K. M. (2022) · Diabetes · doi:10.2337/dbi22-0002 · Cited by 44

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

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Glucagon, cyclic AMP, and hepatic glucose mobilization: A half‐century of uncertainty

Rodgers, R. L. (2022) · Physiological Reports · doi:10.14814/phy2.15263 · Cited by 34

Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-deficient Mice via Increased Glucagon Action

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Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

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Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

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Oxyntomodulin increases intrinsic heart rate through the glucagon receptor

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Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism

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Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer–associated cachexia

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Glucagon receptor signaling at white adipose tissue does not regulate lipolysis

Vasileva, A., Marx, T. R., Beaudry, J. L., & Stern, J. H. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00078.2022 · Cited by 35

Thioesterase Superfamily Member 2 (Them2) and Phosphatidylcholine Transfer Protein (PC-TP) Interact To Promote Fatty Acid Oxidation and Control Glucose Utilization

Kawano, Y., Ersoy, B. A., Li, Y., Nishiumi, S., Yoshida, M., & Cohen, D. E. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01601-13 · Cited by 31

The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic

Goldstein, I., & Hager, G. L. (2017) · Endocrinology · doi:10.1210/en.2017-00521 · Cited by 36

Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes

Chowdhury, M. K. H., Turner, N. A., Bentley, N. L., Das, A., Wu, L. E., Richani, D., Bustamante, S., Gilchrist, R. B., Morris, M. J., Shepherd, P. R., et al. (2017) · Scientific Reports · doi:10.1038/srep40159 · Cited by 32

High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese Asian Indian Males with Type 2 Diabetes in North India

Shajith Anoop, S., Misra, A., Bhatt, S. P., Gulati, S., Mahajan, H., & Prabakaran, G. (2017) · Journal of Diabetes Research · doi:10.1155/2017/2376016 · Cited by 31

Prolonged Glucagon Infusion Does Not Affect Energy Expenditure in Individuals with Overweight/Obesity: A Randomized Trial

Whytock, K. L., Carnero, E. A., Vega, R. B., Tillner, J., Bock, C., Chivukula, K., Yi, F., Meyer, C., Smith, S. R., & Sparks, L. M. (2021) · Obesity · doi:10.1002/oby.23141 · Cited by 30

Metabolic impact of glucagon deficiency

Hayashi, Y. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01456.x · Cited by 31

Why does GLP ‐1 agonist combined with GIP and/or GCG agonist have greater weight loss effect than GLP ‐1 agonist alone in obese adults without type 2 diabetes?

Jiang, Y., Zhu, H., & Gong, F. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16106 · Cited by 35

VASP Increases Hepatic Fatty Acid Oxidation by Activating AMPK in Mice

Tateya, S., Rizzo, N. O., Handa, P., Cheng, A. M., Morgan‐Stevenson, V., Ogimoto, K., Kanter, J. E., Bornfeldt, K., Daum, G., Clowes, A. W., et al. (2013) · Diabetes · doi:10.2337/db12-0325 · Cited by 29

Recent Progress in the Use of Glucagon and Glucagon Receptor Antago-nists in the Treatment of Diabetes Mellitus

Lotfy, M. A., Kalász, H., Szalai, G., Singh, J., & Adeghate, E. A. (2014) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104501408010028 · Cited by 29

Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2

Viscarra, J. A., Wang, Y., Hong, I., & Sul, H. S. (2017) · Science Signaling · doi:10.1126/scisignal.aai8596 · Cited by 29

Orphan Nuclear Receptor Nur77 Mediates Fasting-Induced Hepatic Fibroblast Growth Factor 21 Expression

Min, A.-K., Bae, K.-H., Jung, Y., Choi, Y., Kim, M., Kim, J., Jeon, J., Kim, J., Lee, I., & Park, K. (2014) · Endocrinology · doi:10.1210/en.2013-1758 · Cited by 28

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Shi, M. Y., Yu, H. C., Han, C. Y., Bang, I. H., Park, H. S., Jang, K. Y., Lee, S., Son, J. B., Kim, N. D., Park, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40597-z · Cited by 30

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Sekar, R., Motzler, K., Kwon, Y., Novikoff, A., Jülg, J., Najafi, B., Wang, S., Warnke, A.-L., Seitz, S., Hass, D., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.022 · Cited by 30

Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents

Kani, A. H., Alavian, S. M., Haghighatdoost, F., & Azadbakht, L. (2014) · Hepatitis Monthly · doi:10.5812/hepatmon.10939 · Cited by 27

Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows

Caixeta, L. S., Giesy, S. L., Krumm, C. S., Perfield, J. W., Butterfield, A. M., Schoenberg, K. M., Beitz, D. C., & Boisclair, Y. R. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00197.2017 · Cited by 29

Glucagon resistance and metabolic-associated steatotic liver disease: a review of the evidence

McGlone, E. R., Bloom, S. R., & Tan, T. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0365 · Cited by 30

Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

Nason, S. R., Kim, T., ANTIPENKO, J. P., Finan, B., DiMarchi, R. D., Hunter, C. S., & Habegger, K. M. (2019) · Endocrinology · doi:10.1210/endocr/bqz013 · Cited by 25

Molecular Pathways Underlying the Pathogenesis of Pancreatic α-Cell Dysfunction

Kawamori, D., Welters, H. J., & Kulkarni, R. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_18 · Cited by 26

HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation

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A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity

Vega, R. B., Whytock, K. L., Gassenhuber, J., Goebel, B., Tillner, J., Agueusop, I., Truax, A. D., Yu, G., Carnero, E., Kapoor, N., et al. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab118 · Cited by 24

Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice

Yang, W., Liao, W., Li, X., Ai, W., Pan, Q., Shen, Z., Jiang, W. G., & Guo, S. (2023) · Diabetologia · doi:10.1007/s00125-023-05916-5 · Cited by 27

Hormonal Regulation of Lipogenesis

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Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting

Bertholdt, L., Gudiksen, A., Jessen, H., & Pilegaard, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2185-1 · Cited by 24

Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling

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Multi-organ Coordination of Lipoprotein Secretion by Hormones, Nutrients and Neural Networks

Stahel, P., Xiao, C., Nahmias, A., Tian, L., & Lewis, G. F. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab008 · Cited by 24

Effect of Glucagon on Ischemic Heart Disease and Its Risk Factors: A Mendelian Randomization Study

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Regulation of glucose and lipid metabolism by insulin and glucagon in vivo and in vitro in common carp Cyprinus carpio L.

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Effects of short term fasting on the expression of genes involved in lipid metabolism in chicks

Saneyasu, T., Shiragaki, M., Nakanishi, K., Kamisoyama, H., & Honda, K. (2013) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.03.005 · Cited by 21

Glucagon receptor is required for long-term survival: A natural history study of the Mahvash disease in a murine model

Yu, R., Ren, S.-G., & Mirocha, J. (2012) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2012.06.006 · Cited by 19

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Galsgaard, K. D., Elmelund, E., Johansen, C. D., Bomholt, A. B., Kizilkaya, H. S., Ceutz, F. R., Hunt, J. E., Kissow, H., Winther‐Sørensen, M., Sørensen, C. M., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101639 · Cited by 19

Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives

Sharabi, K., Tavares, C. D. J., & Puigserver, P. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1224-4 · Cited by 21

The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity

Batran, R. A., Gopal, K., Aburasayn, H., Eshreif, A., Almutairi, M. G., Greenwell, A. A., Campbell, S. A., Saleme, B., Court, E. A., Eaton, F., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124643 · Cited by 18

Ablation of glucagon receptor signaling by peptide-based glucagon antagonists improves glucose tolerance in high fat fed mice

McShane, L. M., Franklin, Z. J., O'Harte, F. P. M., & Irwin, N. (2014) · Peptides · doi:10.1016/j.peptides.2014.08.002 · Cited by 18

Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis

Tudurí, E., Denroche, H. C., Kara, J., Asadi, A., Fox, J. K., & Kieffer, T. J. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00681.2013 · Cited by 17

Association of glucagon-to-insulin ratio and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Moh, M. A. M., Jung, C., Lee, B., Choi, D., Kim, B., Kim, C., Kang, S., & Mok, J. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118810691 · Cited by 17

Not the second fiddle: α cell development, identity, and function in health and diabetes

Brooks, E. P., & Sussel, L. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0297 · Cited by 18

Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents

Huet, C., Boudaba, N., Guigas, B., Viollet, B., & Foretz, M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010244 · Cited by 18

Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition.

Marroquí, L., Batista, T. M., González, A., Vieira, E., Rafacho, A., Colleta, S., Taboga, S., Boschero, A., Nadal, A., Carneiro, E., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1623 · Cited by 15

Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish

Bai, X., Jia, J., Kang, Q., Fu, Y., Zhou, Y., Zhong, Y., Zhang, C., & Li, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.605979 · Cited by 17

Factors Affecting Insulin-Regulated Hepatic Gene Expression

Guan, H.-P., & Chen, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00006-5 · Cited by 15

The microRNA-124-iGluR2/3 pathway regulates glucagon release from alpha cells

Zhang, H., Liu, R., Deng, T., Wang, X., Lang, H., Qu, Y., Duan, J., Huang, D., Ying, G., & Ba, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8270 · Cited by 15

The glucose-mobilizing effect of glucagon at fasting is mediated by cyclic AMP

Albrechtsen, N. J. W. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00172.2021 · Cited by 15

SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300

Zhang, Z., Gong, L., Lv, S., Li, J., Tai, X., Cao, W., Peng, B., Qu, S., Li, W., Zhang, C., et al. (2016) · Scientific Reports · doi:10.1038/srep23317 · Cited by 15

Central and Peripheral Glucagon Reduces Hyperlipidemia in Rats and Hamsters

PATEL, V. G., Joharapurkar, A. A., Kshirsagar, S. G., Patel, H., Pandey, D., Patel, D. N., Shah, K., Bahekar, R. H., Shah, G. B., & Jain, M. R. (2017) · Drug Research · doi:10.1055/s-0043-102405 · Cited by 14

Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage

Vardanyan, S., Brosig, A., Merz, H., Ranjbar, M., Kakkassery, V., Grisanti, S., & Tura, A. (2020) · Cancers · doi:10.3390/cancers12082101 · Cited by 13

Hepatocyte cholesterol content modulates glucagon receptor signalling

McGlone, E. R., Ansell, T. B., Dunsterville, C., Song, W., Carling, D., Tomás, A., Bloom, S. R., Sansom, M. S. P., Tan, T., & Jones, B. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101530 · Cited by 14

Impaired Glucagon-Mediated Suppression of VLDL-Triglyceride Secretion in Individuals With Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD)

Heebøll, S., Risikesan, J., Ringgaard, S., Kumarathas, I., Sandahl, T. D., Grønbæk, H., Søndergaard, E., & Nielsen, S. (2022) · Diabetes · doi:10.2337/db22-0313 · Cited by 14

Metabolic response to a glucagon challenge varies with adiposity and life-history stage in fasting northern elephant seals

Crocker, D. E., Fowler, M. A., Champagne, C. D., Vanderlugt, A. L., & Houser, D. S. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.11.005 · Cited by 14

Sleeve gastrectomy causes weight‐loss independent improvements in hepatic steatosis

McGlone, E. R., Siebert, M., Dore, M. H., Hope, D. C. D., Davies, I., Owen, B. M., Khoo, B. C. E., Goldin, R. D., Carling, D., Bloom, S. R., et al. (2023) · Liver International · doi:10.1111/liv.15614 · Cited by 12

Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression

Liu, X., Chen, J., Gu, S., Chen, Y., Zhang, R., Zang, Q., Li, T., Li, H., Lu, D., Hou, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63529-5 · Cited by 16

Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals

Hana, C. A., Tran, L. V., Mölzer, C., Müllner, E., Hörmann-Wallner, M., Franzke, B., Tosevska, A., Zöhrer, P. A., Doberer, D., Marculescu, R., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154913 · Cited by 12

Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network

Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., & Li, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030724 · Cited by 12

Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion

Bethea, M. M., Bozadjieva-Kramer, N., & Sandoval, D. A. (2021) · Endocrinology · doi:10.1210/endocr/bqab150 · Cited by 12

Association of Glucagon to Insulin Ratio and Metabolic Syndrome in Patients with Type 2 Diabetes

Bang, J., Lee, S. A., Koh, G., & Yoo, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185806 · Cited by 12

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

McGlone, E. R., Hope, D. C. D., Davies, I., Dore, M. H., Goldin, R. D., Jones, B. J., Liu, Z., Li, J. V., Vorkas, P. A., Khoo, B. C. E., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116888 · Cited by 12

A famsin-glucagon axis mediates glucose homeostasis

Long, A., Wang, Y., Guo, Y., Hong, J., Ning, G., Meng, Z., Wang, Y., & Wang, Y. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.008 · Cited by 11

Mechanisms of Incretin Effects on Plasma Lipids and Implications for the Cardiovascular System

Xiao, C., Dash, S., & Lewis, G. F. (2012) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152512803530315 · Cited by 11

The ubiquitination status of the glucagon receptor determines signal bias

Kaur, S., Sokrat, B., Capozzi, M. E., EL, K. M., Bai, Y., Jazic, A., Han, B. Y., Kumar, K. K., D’Alessio, D. A., Campbell, J. E., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104690 · Cited by 10

Food protein-derived bioactive peptides for the management of nutrition related chronic diseases

Cao, X., Liao, W., & Wang, S. (2022) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2022.04.004 · Cited by 11

Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells

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Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD

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