Cited by 272Peroxisome Proliferator-Activated ReceptorsLipid metabolism and disordersLipid metabolism and biosynthesis

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

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Abstract

Glucagon receptor (Gcgr) signaling maintains hepatic glucose production during the fasting state; however, the importance of the Gcgr for lipid metabolism is unclear. We show here that fasted Gcgr-/- mice exhibit a significant increase in hepatic triglyceride secretion and fasting increases fatty acid oxidation (FAO) in wild-type (WT) but not in Gcgr-/- mice. Moreover fasting upregulated the expression of FAO-related hepatic mRNA transcripts in Gcgr+/+ but not in Gcgr-/- mice. Exogenous glucagon administration reduced plasma triglycerides in WT mice, inhibited TG synthesis and secretion, and stimulated FA beta oxidation in Gcgr+/+ hepatocytes. The actions of glucagon on TG synthesis and FAO were abolished in PPARalpha-/- hepatocytes. These findings demonstrate that the Gcgr receptor is required for control of lipid metabolism during the adaptive metabolic response to fasting.

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Crossref · 10.1016/j.cmet.2008.09.008

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Metadata

Authors
Longuet, C., Sinclair, E. M., Maida, A., Baggio, L. L., Maziarz, M., Charron, M. J., & Drucker, D. J.
Affiliations
  • Mount Sinai Hospital (CA)
  • Albert Einstein College of Medicine (US)
Corresponding author
Drucker, Daniel J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2008-11
Volume
8
Issue
5
Pages
359-371
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2085330452
Cited by
272
References
47
Citations by year
2026: 14 · 2025: 16 · 2024: 23 · 2023: 17 · 2022: 17 · 2021: 16 · 2020: 17 · 2019: 14 · 2018: 10 · 2017: 20 · 2016: 10 · 2015: 19 · 2014: 18 · 2013: 12 · 2012: 20
FWCI
3.98
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Canadian Institutes of Health Research (10903)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047425, R01DK47425)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
glucagon receptor, fasting, hepatic lipid metabolism, fatty acid oxidation, hepatic triglyceride secretion, triglyceride synthesis, PPARα, glucagon, hepatic glucose production
MeSH terms
Adaptation, Biological, Animals, Cells, Cultured, Fasting, Fatty Acids, Female, Glucagon, Male, Oxidation-Reduction, RNA, Messenger, Triglycerides, Receptors, Glucagon, Mice, Knockout, Hepatocytes, PPAR alpha, p38 Mitogen-Activated Protein Kinases, Lipid Metabolism, Mice, AMP-Activated Protein Kinases

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