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The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Adipogenesis, Glucose Homeostasis, and Energy Metabolism

Li, Luoping, Xie, Xin, Qin, Jun, Jeha, George S., Saha, Pradip K., Yan, Jun, Haueter, Claire M., Chan, Lawrence, Tsai, Sophia Y., Tsai, Ming-Jer·2009·Cell Metabolism
DOI 10.1016/j.cmet.2008.12.002PMC PMC2630393
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  • RNAscope smFISH validated increased expression of GRAMD1B, VEGFB, and NR2F2 in mutant MAPT R406W HNOs compared to isogenic controls.

    “RNAscope smFISH validated the increased expression of GRAMD1B, VEGFB, and NR2F2 in mutant MAPT R406W HNOs compared to isogenic controls.”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [70]

  • Using scRNA-seq, genes (e.g., GRAMD1B, VEGFB, MIAT, COMT, NRP1, DSEL, NR2F2, HMGCS1, and LDLR) and biological pathways related to lipid metabolism are increased in excitatory neurons of MAPT R406W mutant HNOs compared to isogenic control HNOs.

    “Using scRNA-seq, we found that genes (e.g., GRAMD1B, VEGFB, MIAT, COMT, NRP1, DSEL, NR2F2, HMGCS1, and LDLR)9,58,66,69–71 and biological pathways related to lipid metabolism are increased in excitatory neurons of MAPT R406W mutant HNOs compared to isogenic control HNOs (Fig. 4a, b and Supplementary Fig. 2a–c).”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [70]

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Research works printed but not linked: 23

  1. Ailhaud, 1992, Cellular and molecular aspects of adipose tissue development, Annu. Rev. Nutr., 12, 207, 10.1146/annurev.nu.12.070192.001231 · DOI
  2. Biddinger, 2006, From mice to men: insights into the insulin resistance syndromes, Annu. Rev. Physiol., 68, 123, 10.1146/annurev.physiol.68.040104.124723 · DOI
  3. de Luca, 2005, Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes, J. Clin. Invest., 115, 3484, 10.1172/JCI24059 · DOI
  4. Farmer, 2006, Transcriptional control of adipocyte formation, Cell Metab., 4, 263, 10.1016/j.cmet.2006.07.001 · DOI
  5. Fu, 2005, A nuclear receptor atlas: 3T3–L1 adipogenesis, Mol. Endocrinol., 19, 2437, 10.1210/me.2004-0539 · DOI
  6. Hoshizaki, 1994, Embryonic fat-cell lineage in Drosophila melanogaster, Development, 120, 2489, 10.1242/dev.120.9.2489 · DOI
  7. Krssak, 2004, The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans, Rev. Endocr. Metab. Disord., 5, 127, 10.1023/B:REMD.0000021434.98627.dc · DOI · Paper page
  8. Kurihara, 2007, COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity, PLoS Genet., 3, e102, 10.1371/journal.pgen.0030102 · DOI
  9. Lee, 2004, The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development, Mol. Cell. Biol., 24, 10835, 10.1128/MCB.24.24.10835-10843.2004 · DOI
  10. Moldes, 2003, Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis, Biochem. J., 376, 607, 10.1042/bj20030426 · DOI
  11. Pereira, 1999, The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development, Genes Dev., 13, 1037, 10.1101/gad.13.8.1037 · DOI
  12. Petit, 2007, Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency, Proc. Natl. Acad. Sci. USA, 104, 6293, 10.1073/pnas.0702039104 · DOI
  13. Rosen, 2002, The molecular control of adipogenesis, with special reference to lymphatic pathology, Ann. N Y Acad. Sci., 979, 143, 10.1111/j.1749-6632.2002.tb04875.x · DOI
  14. Rosen, 2000, Molecular regulation of adipogenesis, Annu. Rev. Cell Dev. Biol., 16, 145, 10.1146/annurev.cellbio.16.1.145 · DOI
  15. Ross, 2000, Inhibition of adipogenesis by Wnt signaling, Science, 289, 950, 10.1126/science.289.5481.950 · DOI
  16. Saha, 2004, Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice, J. Biol. Chem., 279, 35150, 10.1074/jbc.M405499200 · DOI
  17. Spiegelman, 2001, Obesity and the regulation of energy balance, Cell, 104, 531, 10.1016/S0092-8674(01)00240-9 · DOI · Paper page
  18. Takamoto, 2005, Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction, Mol. Endocrinol., 19, 2299, 10.1210/me.2005-0019 · DOI
  19. Takamoto, 2005, COUP-TFII is essential for radial and anteroposterior patterning of the stomach, Development, 132, 2179, 10.1242/dev.01808 · DOI
  20. Wu, 1999, Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity, Mol. Cell, 3, 151, 10.1016/S1097-2765(00)80306-8 · DOI
  21. Xu, 2008, The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis, Proc. Natl. Acad. Sci. USA, 105, 2421, 10.1073/pnas.0707082105 · DOI
  22. You, 2005, Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity, Nature, 435, 98, 10.1038/nature03511 · DOI
  23. You, 2005, Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia, Proc. Natl. Acad. Sci. USA, 102, 16351, 10.1073/pnas.0507832102 · DOI

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Metadata

Authors
Li, L., Xie, X., Qin, J., Jeha, G. S., Saha, P. K., Yan, J., Haueter, C. M., Chan, L., Tsai, S. Y., & Tsai, M.-J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2009-01
Volume
9
Issue
1
Pages
77-87
ISSN
1550-4131
DOI
10.1016/j.cmet.2008.12.002
PMC
PMC2630393
Cited by
127
References
0
Language
en
Licence

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