Cited by 326Iron Metabolism and DisordersNeurological diseases and metabolismFerroptosis and cancer prognosis

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Open access

Gao, Junwei, Chen, Juxing, Kramer, Maxwell, Tsukamoto, Hidekazu, Zhang, An-Sheng, Enns, Caroline A.·2009·Cell Metabolism

DOI 10.1016/j.cmet.2009.01.010PMC PMC2673483

Open this paper in CoChat — free account Open PDF

Abstract

The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most common form of hereditary iron overload have mutations in the hereditary hemochromatosis protein HFE. They have lower levels of hepcidin than unaffected individuals. Hepcidin, a hepatic peptide hormone, negatively regulates iron efflux from the intestines into the blood. We report two hepatic cell lines, WIF-B cells and HepG2 cells transfected with HFE, where hepcidin expression responded to iron-loaded transferrin. The response was abolished when endogenous transferrin receptor 2 (TfR2) was suppressed or in primary hepatocytes lacking either functional TfR2 or HFE. Furthermore, transferrin-treated HepG2 cells transfected with HFE chimeras containing only the alpha3 and cytoplasmic domains could upregulate hepcidin expression. Since the HFE alpha3 domain interacts with TfR2, these results supported our finding that TfR2/HFE complex is required for transcriptional regulation of hepcidin by holo-Tf.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2009.01.010

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Firefly Luciferase Gene: Structure and Expression in Mammalian Cells
de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebrón, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., & Schatzman, R. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1472 · Cited by 827
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
Camaschella, C., Roetto, A., Calì, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A., & Gasparini, P. (2000) · Nature Genetics · doi:10.1038/75534 · Cited by 803
Molecular Cloning of Transferrin Receptor 2
Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 661

Flagged first, then by citations

Show all 57 references

Sorted by citations

Items 101–200 of 325

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo
Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J. C., Chen, J., Enns, C. A., & Wessling‐Resnick, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070199 · Cited by 57
Self-citation
Transgenic HFE‐dependent induction of hepcidin in mice does not require transferrin receptor‐2
Schmidt, P. J., & Fleming, M. D. (2012) · American Journal of Hematology · doi:10.1002/ajh.23173 · Cited by 56
Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations
Nelson, J. E., Brunt, E. M., & Kowdley, K. V. (2012) · Hepatology · doi:10.1002/hep.25856 · Cited by 55
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis
Ramos, P., Guy, E. C., Chen, N., Proenca, C. C., Gardenghi, S., Casu, C., Follenzi, A., van Rooijen, N., Grady, R. W., de Sousa, M. A. B., et al. (2010) · Blood · doi:10.1182/blood-2010-09-307462 · Cited by 55
Red Blood Cell Distribution Width is a Biomarker of Red Cell Dysfunction Associated with High Systemic Inflammation and a Prognostic Marker in Heart Failure and Cardiovascular Disease: A Potential Predictor of Atrial Fibrillation Recurrence
García‐Escobar, A., Lázaro-García, R., Goicolea-Ruigómez, J., González‐Casal, D., Fontenla, A., Soto, N., González‐Panizo, J., Datino, T., Pizarro, G., Moreno, R., et al. (2024) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-024-00662-0 · Cited by 58
Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease
Dostalikova‐Cimburova, M., Balušíková, K., Krátká, K., Chmelíková, J., Hejda, V., Hnaníček, J., Neubauerová, J., Vránová, J., Kovár̆, J., & Horák, J. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12310 · Cited by 52
The extrahepatic role of TFR2 in iron homeostasis
Silvestri, L., Nai, A., Pagani, A., & Camaschella, C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00093 · Cited by 52
Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
Chung, B., Verdier, F., Matak, P., Deschemin, J., Mayeux, P., & Vaulont, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-152561 · Cited by 51
Update on iron metabolism and molecular perspective of common genetic and acquired disorder, hemochromatosis
Yun, S., & Vincelette, N. D. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.02.006 · Cited by 52
Iron and inflammation – the gut reaction
Verma, S., & Cherayil, B. J. (2017) · Metallomics · doi:10.1039/c6mt00282j · Cited by 51
Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling
Wilkinson, H. N., Upson, S. E., Banyard, K. L., Knight, R., Mace, K. A., & Hardman, M. J. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.05.014 · Cited by 49
Liver Iron Loading in Alcohol-Associated Liver Disease
Ali, N., Ferrao, K., & Mehta, K. J. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.08.010 · Cited by 49
In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
Rishi, G., Crampton, E. M., Wallace, D. F., & Subramaniam, V. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077267 · Cited by 52
Factors influencing disease phenotype and penetrance in HFE haemochromatosis
Rochette, J., Gac, G. L., Lassoued, K., Férec, C., & Robson, K. (2010) · Human Genetics · doi:10.1007/s00439-010-0852-1 · Cited by 52
Iron Deficiency Anaemia
Zeng, L., Pei, L., Li, C. L., & Yan, H. (2018) · InTech eBooks · doi:10.5772/intechopen.69048 · Cited by 50
IL-6 Regulates Hepcidin Expression Via the BMP/SMAD Pathway by Altering BMP6, TMPRSS6 and TfR2 Expressions at Normal and Inflammatory Conditions in BV2 Microglia
Varga, E., Pap, R., Jánosa, G., Sipos, K., & Pandur, E. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03322-0 · Cited by 60
Iron storage disease in A sia‐ P acific populations: The importance of non‐ HFE mutations
McDonald, C. J., Wallace, D. F., Crawford, D. H., & Subramaniam, V. N. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12222 · Cited by 49
Hepcidin assay in serum by SELDI-TOF-MS and other approaches
Castagna, A., Campostrini, N., Zaninotto, F., & Girelli, D. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.08.003 · Cited by 49
Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia
Xiao, X., Moschetta, G. A., Xu, Y., Fisher, A. L., Alfaro-Magallanes, V. M., Dev, S., Wang, C., & Babitt, J. L. (2022) · Blood · doi:10.1182/blood.2022017811 · Cited by 47
A Computational Model of Liver Iron Metabolism
Mitchell, S. A., & Mendes, P. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003299 · Cited by 47
Hyperferritinaemia-cataract syndrome: Worldwide mutations and phenotype of an increasingly diagnosed genetic disorder
Millonig, G., Muckenthaler, M. U., & Mueller, S. (2010) · Human Genomics · doi:10.1186/1479-7364-4-4-250 · Cited by 47
Managing the Dual Nature of Iron to Preserve Health
Silvestri, L., Pettinato, M., Furiosi, V., Volpe, L. B., Nai, A., & Pagani, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043995 · Cited by 49
Non-HFE hemochromatosis: Pathophysiological and diagnostic aspects
Bardou‐Jacquet, E., Ali, Z. B., Beaumont-Epinette, M.-P., Loréal, O., Jouanolle, A., & Brissot, P. (2013) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2013.11.003 · Cited by 47
Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications
Czaja, A. J. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15173 · Cited by 47
Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease
Johnstone, D. M., & Milward, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06697.x · Cited by 44
Modulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders
Schmidt, P. J., & Fleming, M. D. (2014) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2013.11.004 · Cited by 43
Hepcidin and the iron enigma in HCV infection
Georgopoulou, U., Dimitriadis, A., Foka, P., Karamichali, E., & Mamalaki, A. (2014) · Virulence · doi:10.4161/viru.28508 · Cited by 43
Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women
Blanco-Rojo, R., Baeza, C., López-Parra, A. M., Pérez-Granados, A. M., Brichs, A., Bertoncini, S., Buil, A., Arroyo‐Pardo, E., Soria, J. M., & Vaquero, M. P. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-69 · Cited by 41
Molecular pathogenesis and clinical consequences of iron overload in liver cirrhosis
Sikorska, K., Bernat, A., & Wróblewska, A. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60135-2 · Cited by 41
Unraveling Mechanisms Regulating Systemic Iron Homeostasis
Finberg, K. E. (2011) · Hematology · doi:10.1182/asheducation-2011.1.532 · Cited by 41
Regulation of cellular iron metabolism and its implications in lung cancer progression
Xiong, W., Wang, L., & Yu, F. (2014) · Medical Oncology · doi:10.1007/s12032-014-0028-2 · Cited by 39
Coordination of iron homeostasis by bone morphogenetic proteins: Current understanding and unanswered questions
Fisher, A. L., & Babitt, J. L. (2021) · Developmental Dynamics · doi:10.1002/dvdy.372 · Cited by 41
Hereditary hemochromatosis and transferrin receptor 2
Chen, J., & Enns, C. A. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.07.015 · Cited by 38
Self-citation
Pathogenic Mechanisms Underlying Iron Deficiency and Iron Overload: New Insights for Clinical Application.
Kotze, M. J., van Velden, D. P., van Rensburg, S. J., & Erasmus, R. T. (2009) · PubMed Central · Cited by 37
Iron effects versus metabolic alterations in hereditary hemochromatosis driven bone loss
Baschant, U., Altamura, S., Steele-Perkins, P., Muckenthaler, M. U., Spasić, M. V., Hofbauer, L. C., Steinbicker, A. U., & Rauner, M. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.004 · Cited by 37
Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis
Shanmugam, N. K. N., Ellenbogen, S., Trebicka, E., Wang, L., Mukhopadhyay, S., Lacy‐Hulbert, A., Gallini, C. A., Garrett, W. S., & Cherayil, B. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038136 · Cited by 37
The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice
Nai, A., Pellegrino, R. M., Rausa, M., Pagani, A., Boero, M., Silvestri, L., Saglio, G. N., Roetto, A., & Camaschella, C. (2014) · Haematologica · doi:10.3324/haematol.2013.103143 · Cited by 36
Molecular mechanisms of hepcidin regulation in sea bass (Dicentrarchus labrax)
Neves, J. V., Caldas, C., Wilson, J. M., & Rodrigues, P. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.10.006 · Cited by 38
Molecular perspective of iron uptake, related diseases, and treatments
Shokrgozar, N., & Golafshan, H. (2019) · Blood Research · doi:10.5045/br.2019.54.1.10 · Cited by 37
TfR2 expression in human colon carcinomas
Calzolari, A., Deaglio, S., Maldi, E., Cassoni, P., Malavasi, F., & Testa, U. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.08.001 · Cited by 32
Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin
KENT, P. G., Wilkinson, N., Constante, M., Fillebeen, C., Gkouvatsos, K., Wagner, J., Buffler, M., Becker, C., Schümann, K., Santos, M. M., et al. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1253-7 · Cited by 32
Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2‐deficient mice, but serum iron fails to induce hepcidin in Bmp6‐deficient mice
Wang, C., Canali, S., Bayer, A. L., Dev, S., Agarwal, A., & Babitt, J. L. (2018) · American Journal of Hematology · doi:10.1002/ajh.25366 · Cited by 33
Recent advances in the understanding of iron overload in sideroblastic myelodysplastic syndrome
Cuijpers, M. L. H., Raymakers, R. A. P., MacKenzie, M. A., de Witte, T. J. M., & Swinkels, D. W. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.08051.x · Cited by 32
Erythropoiesis and transferrin receptors
Moura, I. C., Hermine, O., Lacombe, C., & Mayeux, P. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000133 · Cited by 32
Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis
Chua, A. C. G., Delima, R. D., Morgan, E. H., Herbison, C. E., Tirnitz‐Parker, J. E. E., Graham, R. M., Fleming, R. E., Britton, R. S., Bacon, B. R., Olynyk, J. K., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.010 · Cited by 34
Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption
Ye, K., Cao, C. Q., Lin, X., O'Brien, K. O., & Gu, Z. (2015) · BMC Genetics · doi:10.1186/s12863-015-0223-y · Cited by 31
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., et al. (2014) · Nature Communications · doi:10.1038/ncomms5926 · Cited by 30
“These reports are consistent with evidence that TFR2 and HFE proteins interact in control of hepcidin signaling; they may form an iron-sensing complex that modulates hepcidin expression in response to blood levels of diferric transferrin 61, 62 .”
New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia
Liu, J., Liu, W., Liu, Y., Miao, Y., Guo, Y., Song, H., Wang, F., Zhou, H., Ganz, T., Yan, B., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.209874 · Cited by 30
Iron metabolism: microbes, mouse, and man
Latunde‐Dada, G. O. (2009) · BioEssays · doi:10.1002/bies.200900101 · Cited by 29
Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders
Camaschella, C., & Silvestri, L. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.130 · Cited by 28
Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver
Matsuo, S., Ogawa, M., Muckenthaler, M. U., Mizui, Y., Sasaki, S., Fujimura, T., Takizawa, M., Ariga, N., Ozaki, H., Sakaguchi, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.694414 · Cited by 30
Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6
Lee, P. L., Hsu, M., Welser-Alves, J. V., & Peng, H. (2012) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.12.005 · Cited by 31
20 years of Hepcidin: How far we have come
Colucci, S., Marques, O., & Altamura, S. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.05.001 · Cited by 28
Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist
van Deuren, M., Kroot, J. J., & Swinkels, D. W. (2009) · Haematologica · doi:10.3324/haematol.2009.005975 · Cited by 28
The Role of Iron in Benign and Malignant Hematopoiesis
Sinha, S., Pereira-Reis, J., Guerra, A., Rivella, S., & Duarte, D. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8155 · Cited by 29
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
Rapisarda, C., Puppi, J., Hughes, R. D., Dhawan, A. K., Farnaud, S., Evans, R. W., & Sharp, P. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00157.2010 · Cited by 28
The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value
Roetto, A., Mezzanotte, M., & Pellegrino, R. M. (2018) · Pharmaceuticals · doi:10.3390/ph11040115 · Cited by 27
Effect of pH on the stability of hemochromatosis factor E: a combined spectroscopic and molecular dynamics simulation-based study
Κhan, P., Shandilya, A., Jayaram, B., Islam, A., Ahmad, F., & Hassan, M. I. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1189359 · Cited by 26
Effects of Pregnancy and Lactation on Iron Metabolism in Rats
Gao, G., Liu, S.-Y., Wang, H., Zhang, T.-W., Yu, P., Duan, X., Zhao, S.-E., & Chang, Y.-Z. (2015) · BioMed Research International · doi:10.1155/2015/105325 · Cited by 26
Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin
Li, J., Li, Y., Zhou, X., Yang, S., Liu, D., Wen, H., Chen, X., Duan, C., Yu, M., Zhang, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02486-3 · Cited by 24
Recent advances in iron metabolism and related disorders
Camaschella, C., & Strati, P. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-010-0387-4 · Cited by 25
A Serine/Threonine Kinase 16-Based Phospho-Proteomics Screen Identifies WD Repeat Protein-1 As A Regulator Of Constitutive Secretion
López-Coral, A., Striz, A., & Tuma, P. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-31426-1 · Cited by 22
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin
Schmidt, P. J., Andrews, N. C., & Fleming, M. D. (2010) · Blood · doi:10.1182/blood-2010-04-277954 · Cited by 23
Hemochromatosis Enhances Tumor Progression via Upregulation of Intracellular Iron in Head and Neck Cancer
Lenarduzzi, M., Hui, A. B., Yue, S., Ito, E., Shi, W., Williams, J. P., Bruce, J., Sakemura-Nakatsugawa, N., Xu, W., Schimmer, A. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074075 · Cited by 23
Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients
Ambachew, S., & Biadgo, B. (2017) · Acta Haematologica · doi:10.1159/000481391 · Cited by 23
Signaling pathways regulating hepcidin
Rishi, G., & Subramaniam, V. N. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.003 · Cited by 23
Hepcidin and its role in inflammatory bowel disease.
Dudkowiak, R., Neubauer, K., & Poniewierka, E. (2013) · PubMed · Cited by 22
Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice
McDonald, C. J., Wallace, D. F., Ostini, L., & Subramaniam, V. N. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00256.2013 · Cited by 22
Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis
Xu, T., Zhang, X., Zhao, W., Shi, J., Wan, S., Zhang, Y., Hao, Y., Sun, M., He, J., Jiang, L., et al. (2024) · Blood · doi:10.1182/blood.2024024293 · Cited by 22
Iron Sensing as a Partnership: HFE and Transferrin Receptor 2
Fleming, R. E. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.004 · Cited by 22
ER Stress and Iron Homeostasis: A New Frontier for the UPR
Oliveira, S. J., de Sousa, M. A. B., & Pinto, J. P. (2010) · Biochemistry Research International · doi:10.1155/2011/896474 · Cited by 23
HJV and HFE Play Distinct Roles in Regulating Hepcidin
Wu, Q., Wang, H., An, P., Tao, Y., Deng, J., Zhang, Z., Shen, Y., Chen, C., Min, J., & Wang, F. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5819 · Cited by 22
Hepcidin in chronic kidney disease anemia
Santos‐Silva, A., Ribeiro, S., Reis, F., & Belo, L. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.012 · Cited by 23
Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
Rishi, G., Secondes, E. S., Wallace, D. F., & Subramaniam, V. N. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00291.2015 · Cited by 21
Stoichiometries of transferrin receptors 1 and 2 in human liver
Chloupková, M., Zhang, A.-S., & Enns, C. A. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.09.004 · Cited by 21
Self-citation
Differential HFE Gene Expression Is Regulated by Alternative Splicing in Human Tissues
Martins, R., Silva, B. D. R., Proença, D., & Faustino, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017542 · Cited by 21
The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption – a stable iron isotope study in Taiwanese women
Buerkli, S., Pei, S., Hsiao, S., Lee, C., Zeder, C., Zimmermann, M. B., & Moretti, D. (2020) · Haematologica · doi:10.3324/haematol.2020.264556 · Cited by 20
Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels
Martins, R., Proença, D., Silva, B. D. R., Barbosa, C., Silva, A. L., Faustino, P., & Romão, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035461 · Cited by 19
Ubiquitination of lysine-331 by Kaposi's sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradation
Rhodes, D. A., Boyle, L. H., Boname, J. M., Lehner, P. J., & Trowsdale, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003421107 · Cited by 18
DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression
Sharp, P., Clarkson, R., Hussain, A., Weeks, R. J., & Morison, I. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197863 · Cited by 19
Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells
Mehta, K. J., & Sharp, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-78348-5 · Cited by 19
Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States
Dandrea, P., Giampieri, F., & Battino, M. (2023) · Nutrients · doi:10.3390/nu15245081 · Cited by 16
Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2
Zhang, R., Huang, X., Li, Y., Yu, Z., Wu, Y., Zha, B., Ding, H., Zang, S., & Liu, J. (2021) · Endocrine Connections · doi:10.1530/ec-21-0316 · Cited by 18
Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver
Bloomer, S. A., Kregel, K. C., & Brown, K. E. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.07.012 · Cited by 19
Novel pathway for iron deficiency in pediatric non-alcoholic steatohepatitis
Moya, D. A., Baker, S. S., Liu, W., Garrick, M. D., Kozielski, R., Baker, R. D., & Zhu, L. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.06.011 · Cited by 20
Iron, Oxidative Stress and Health
Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17
Red Blood Cell Distribution Width as a Biomarker of Red Cell Dysfunction Associated with Inflammation and Macrophage Iron Retention: A Prognostic Marker in Heart Failure and a Potential Predictor for Iron Replacement Responsiveness
García‐Escobar, A., Lázaro-García, R., Goicolea-Ruigómez, J., Pizarro, G., y, A. J.-R., Moreno, R., & Cabrera, J. Á. (2024) · Cardiac failure review · doi:10.15420/cfr.2024.17 · Cited by 18
Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression
Huang, X. B., Wu, J., Li, Q., Gu, S., Chen, Z., & Wang, K. (2017) · RSC Advances · doi:10.1039/c7ra09576g · Cited by 17
Molecular Mechanisms of Iron Metabolism and Overload
Tayal, A., Kaur, J., Sadeghi, P., & Maitta, R. W. (2025) · Biomedicines · doi:10.3390/biomedicines13092067 · Cited by 24
Erythroferrone and hepcidin as mediators between erythropoiesis and iron metabolism during allogeneic hematopoietic stem cell transplant
Pirotte, M., Fillet, M., Seidel, L., Jaspers, A., Baron, F., & Beguin, Y. P. (2021) · American Journal of Hematology · doi:10.1002/ajh.26300 · Cited by 16
Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population
Faria, R., Silva, B. D. R., Silva, C., Loureiro, P., Queiroz, A. M., Fraga, S., Esteves, J., Mendes, D., Fleming, R., Vieira, L., et al. (2016) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2016.07.004 · Cited by 16
Iron-deficiency anemia secondary to mutations in genes controlling hepcidin
Cau, M., Melis, M. A., Congiu, R., & Galanello, R. (2010) · Expert Review of Hematology · doi:10.1586/ehm.10.2 · Cited by 16
Ferrata Storti Foundation
Storti, F. (2008) · Cited by 16
Importance of Iron Absorption in Human Health: An Overview
Dixit, S. P., Logesh, R., Palaniswamy, D. S., & Mohankumar, S. K. (2020) · Current Nutrition & Food Science · doi:10.2174/1573401316999200801021752 · Cited by 18
Heme‐related gene expression signatures of meat intakes in lung cancer tissues
Lam, T. K., Rotunno, M., Ryan, B. M., Pesatori, A. C., Bertazzi, P. A., Spitz, M. R., Caporaso, N. E., & Landi, M. T. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22006 · Cited by 16
Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson’s disease in Southern Italy
Greco, V., Marco, E. V. D., Rocca, F., Annesi, F., Civitelli, D., Provenzano, G., Tarantino, P., Scornaienchi, V., Pucci, F., Salsone, M., et al. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0504-9 · Cited by 16
Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines
Dion, S. P., Béliveau, F., Morency, L.-P., Désilets, A., Najmanovich, R., & Leduc, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-30618-z · Cited by 15
Brain transcriptome perturbations in the Hfe−/− mouse model of genetic iron loading
Johnstone, D. M., Graham, R. M., Trinder, D., Delima, R. D., Riveros, C., Olynyk, J. K., Scott, R. J., Moscato, P., & Milward, E. A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.006 · Cited by 14
Association between hereditary hemochromatosis and hepatocellular carcinoma: a comprehensive review
Jayachandran, A., Shrestha, R., Bridle, K. R., & Crawford, D. H. (2020) · Hepatoma Research · doi:10.20517/2394-5079.2019.35 · Cited by 14
Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron‐regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content
Duan, Q., Tait, R. G., Mayes, M. S., Garrick, D. J., Liu, Q., Eenennaam, A. L. V., Mateescu, R. G., Overbeke, D. L. V., Garmyn, A. J., Beitz, D. C., et al. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2011.02224.x · Cited by 14

Authors: Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A.-S., & Enns, C. A.
Affiliations: Oregon Health & Science University (US)
University of Southern California (US)
Corresponding author: Enns, Caroline A.
ORCID: Gao, Junwei
Chen, Juxing
Kramer, Maxwell
Tsukamoto, Hidekazu
Zhang, An-Sheng
Enns, Caroline A.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2009-03
Volume: 9
Issue: 3
Pages: 217-227
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2009.01.010
PMC: PMC2673483
OpenAlex: W2079904892
Cited by: 326
References: 57
Citations by year: 2026: 10 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 19 · 2013: 30 · 2012: 22
FWCI: 27.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1635 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AA011999, DK072166)
National Institute on Alcohol Abuse and Alcoholism (P50AA011999)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK054488, R01DK072166, R01DK054488)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: hereditary hemochromatosis, HFE gene, transferrin receptor 2, hepcidin, iron homeostasis, iron overload, transferrin, transcriptional regulation, hepatocytes, iron sensing
MeSH terms: Hemochromatosis Protein, Animals, Cells, Cultured, Homeostasis, Humans, Iron, Liver, Membrane Proteins, Promoter Regions, Genetic, Receptors, Transferrin, Recombinant Fusion Proteins, Transferrin, Histocompatibility Antigens Class I, Antigens, CD, Mice, Knockout, Hepatocytes, Antimicrobial Cationic Peptides, RNA, Small Interfering, Mice, Hepcidins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks