TfR2 expression in human colon carcinomas
Abstract
Different proteins regulate iron metabolism at the level of various tissues. Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis. Although TfR2 expression in normal tissues is restricted at the level of the liver, we observed that TfR2 is frequently expressed in cancer cell lines. Taking advantage of this observation we investigated TfR2 expression in primary colon cancers, and showed that this receptor is expressed in about 26% of cases. TfR2 expression in colon cancer is not related to histological grade, but is preferentially associated with mucinous tumors. In colon cancer cell lines, TfR2 is localized in membrane lipid rafts, induces ERK1/ERK2 phosphorylation, when activated by its ligand transferring, and is preferentially expressed during S-M phases of the cell cycle. The presence of TfR2 on the membrane of colon cancer cells may contribute the growth advantage to these cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TfR2 is frequently upregulated in cancer cells.
“Moreover, the homologous TfR2 is also frequently upregulated in cancer cells [29,30].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [29]
Cites
Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439 · see citing works
Lipid rafts and signal transduction
Simons, K., & Toomre, D. K. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 6,252 · see citing works
Prognostic Factors in Prostate Cancer
Bostwick, D. G., Grignon, D. J., Hammond, M. E., Amin, M. B., Cohen, M., Crawford, D., Gospadarowicz, M., Kaplan, R. S., Miller, D. S., Montironi, R., et al. (2000) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2000-124-0995-pfipc · Cited by 1,365 · see citing works
Prognostic Factors in Colorectal Cancer
Compton, C. C., FIELDING, L. P., Burgart, L. J., Conley, B. A., Cooper, H. S., Hamilton, S. R., Hammond, M. E. H., Henson, D. E., Hutter, R. V. P., Nagle, R. B., et al. (2000) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2000-124-0979-pficc · Cited by 1,251 · see citing works
The MAPK signalling pathways and colorectal cancer
Fang, J. Y., & Richardson, B. C. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70168-6 · Cited by 1,185 · see citing works
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Sebolt, J. S., Dudley, D. T., Herrera, R., Becelaere, K. V., Wiland, A. M., Gowan, R. C., Tecle, H., Barrett, S. D., Bridges, A. J., Przybranowski, S. A., et al. (1999) · Nature Medicine · doi:10.1038/10533 · Cited by 972 · see citing works
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
Camaschella, C., Roetto, A., Calì, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A., & Gasparini, P. (2000) · Nature Genetics · doi:10.1038/75534 · Cited by 803 · see citing works
Molecular Cloning of Transferrin Receptor 2
Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 646 · see citing works
American Joint Committee on Cancer prognostic factors consensus conference
Compton, C. C., Fenoglio‐Preiser, C. M., Pettigrew, N. M., & FIELDING, L. P. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000401)88:7 · Cited by 592 · see citing works
Transferrin receptor is necessary for development of erythrocytes and the nervous system
Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574 · see citing works
Transferrin receptors in human tissues: their distribution and possible clinical relevance.
Gatter, K. C., Brown, G., Trowbridge, I. S., Woolston, R.-E., & Mason, D. Y. (1983) · Journal of Clinical Pathology · doi:10.1136/jcp.36.5.539 · Cited by 530 · see citing works
Hepcidin is decreased in TFR2 hemochromatosis
Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., & Camaschella, C. (2004) · Blood · doi:10.1182/blood-2004-08-3042 · Cited by 396 · see citing works
Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A.-S., & Enns, C. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.010 · Cited by 326 · see citing works
Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., & Sly, W. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040548097 · Cited by 273 · see citing works
New mutations inactivating transferrin receptor 2 in hemochromatosis type 3
Roetto, A., Totaro, A., Piperno, A., Piga, A. G., Longo, F., Garozzo, G., Calı̀, A., Gobbi, M. D., Gasparini, P., & Camaschella, C. (2001) · Blood · doi:10.1182/blood.v97.9.2555 · Cited by 247 · see citing works
Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo
Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., SAID, J. W., & Koeffler, H. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908846199 · Cited by 245 · see citing works
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
Fleming, R. E., Ahmann, J. R., Migas, M. C., Waheed, A., Koeffler, H. P., Kawabata, H., Britton, R. S., Bacon, B. R., & Sly, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162360699 · Cited by 244 · see citing works
Kawabata, H., Fleming, R. E., Gui, D., Moon, S. Y., Saitoh, T., O’Kelly, J., Umehara, Y., Wano, Y., SAID, J. W., & Koeffler, H. P. (2004) · Blood · doi:10.1182/blood-2004-04-1416 · Cited by 238 · see citing works
Modulation of iron transport proteins in human colorectal carcinogenesis
Brookes, M. J., Hughes, S., Turner, F. E., Reynolds, G., Sharma, N., Ismail, T., Berx, G., McKie, A. T., Hotchin, N., Anderson, G. J., et al. (2006) · Gut · doi:10.1136/gut.2006.094060 · Cited by 226 · see citing works
Lisanti, M. P., Tang, Z., & Sargiacomo, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.3.595 · Cited by 198 · see citing works
Catalano, V., Loupakis, F., Graziano, F., Torresi, U., Bisonni, R., Mari, D., Fornaro, L., Baldelli, A. M., Giordani, P., Rossi, D., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604955 · Cited by 192 · see citing works
Calzolari, A., Raggi, C., Deaglio, S., Sposi, N. M., Stafsnes, M., Fecchi, K., Parolini, I., Malavasi, F., Peschle, C., Sargiacomo, M., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03228 · Cited by 190 · see citing works
Self-citationIron and Colorectal Cancer Risk: Human Studies
Nelson, R. L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2001.tb07002.x · Cited by 181 · see citing works
Mucinous carcinoma—Just another colon cancer?
Green, J. B., Timmcke, A. E., Mitchell, W., Hicks, T. C., Gathright, B. J., & Ray, J. E. (1993) · Diseases of the Colon & Rectum · doi:10.1007/bf02050301 · Cited by 175 · see citing works
Body Iron Stores and Risk of Colonic Neoplasia
Nelson, R. L., Davis, F. G., Sutter, E., Sobin, L. H., Kikendall, J. W., & Bowen, P. E. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.6.455 · Cited by 174 · see citing works
Transferrin receptor 2 is frequently expressed in human cancer cell lines
Calzolari, A., Oliviero, I., Deaglio, S., Mariani, G., Biffoni, M., Sposi, N. M., Malavasi, F., Peschle, C., & Testa, U. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.02.003 · Cited by 171 · see citing works
Self-citationTwo Subtypes of Mucinous Adenocarcinoma of The Colorectum: Clinicopathological and Genetic Features
Sarli, L., Bottarelli, L., Azzoni, C., Cola, G. D., Barilli, A. L., Costi, R., Mazzeo, A., Salvemini, C., Porrini, C., Cecchini, S., et al. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9757-1 · Cited by 162 · see citing works
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
Wallace, D. F., Summerville, L., Lusby, P. E., & Subramaniam, V. N. (2005) · Gut · doi:10.1136/gut.2004.062018 · Cited by 160 · see citing works
Negri, F., Wotherspoon, A. C., Cunningham, D., Norman, A. R., Chong, G., & Ross, P. J. (2005) · Annals of Oncology · doi:10.1093/annonc/mdi244 · Cited by 158 · see citing works
Primary Mucinous Adenocarcinomas and Signet-Ring Cell Carcinomas of Colon and Rectum
Secco, G. B., Fardelli, R., Campora, E., Lapertosa, G., Gentile, R., Zoli, S., & Prior, C. (2009) · Oncology · doi:10.1159/000227306 · Cited by 149 · see citing works
Regulation of expression of murine transferrin receptor 2
Kawabata, H., Germain, R. S., Ikezoe, T., Tong, X., Green, E. M., Gombart, A. F., & Koeffler, H. P. (2001) · Blood · doi:10.1182/blood.v98.6.1949 · Cited by 139 · see citing works
Association Between Hemochromatosis (HFE) Gene Mutation Carrier Status and the Risk of Colon Cancer
Shaheen, N. J., Silverman, L. M., Keku, T. O., Lawrence, L. B., Rohlfs, E. M., Martin, C. F., Galanko, J., & Sandler, R. S. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.2.154 · Cited by 131 · see citing works
Altered iron metabolism, transferrin receptor 1 and ferritin in patients with colon cancer
Prutki, M., Poljak‐Blaži, M., Jakopović, M., Tomas, D., Stipančić, I., & Žarković, N. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.001 · Cited by 129 · see citing works
Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
Wallace, D. F., Summerville, L., & Subramaniam, V. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.028 · Cited by 124 · see citing works
Ramey, G., Deschemin, J., & Vaulont, S. (2009) · Haematologica · doi:10.3324/haematol.2008.003541 · Cited by 122 · see citing works
Hepatic iron overload and hepatocellular carcinoma
Kew, M. C. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.11.001 · Cited by 107 · see citing works
Increased hepcidin expression in colorectal carcinogenesis
Ward, D. G., Roberts, K., Brookes, M., Joy, H., Martin, A., Ismail, T., Spychal, R., Iqbal, T. H., & Tselepis, C. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.1339 · Cited by 105 · see citing works
Breast Carcinoma and the Role of Iron Metabolism
Elliott, R. L., Elliott, M. C., Wang, F., & Head, J. F. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb17204.x · Cited by 99 · see citing works
Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics
Song, G. A., Deng, G., Bell, I., Kakar, S., Sleisenger, M. H., & Kim, Y. S. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.3.745 · Cited by 87 · see citing works
Deaglio, S., Capobianco, A., Calı̀, A., Bellora, F., Alberti, F., Righi, L., Sapino, A., Camaschella, C., & Malavasi, F. (2002) · Blood · doi:10.1182/blood-2002-01-0076 · Cited by 86 · see citing works
Self-citationWhat we could do now: molecular pathology of colorectal cancer: Figure 1
Houlston, R. S. (2001) · Molecular Pathology · doi:10.1136/mp.54.4.206 · Cited by 73 · see citing works
Mucinous carcinomas of the colon and rectum. An analysis of 62 stage B and C lesions.
Connelly, J. H., Robey-Cafferty, S. S., & Cleary, K. R. (1991) · PubMed · Cited by 67 · see citing works
Voisin, L., Julien, C., Duhamel, S., Gopalbhai, K., Claveau, I., Saba-El-Leil, M. K., Rodrigue‐Gervais, I. G., Gaboury, L. A., Lamarre, D., Basik, M., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-337 · Cited by 67 · see citing works
Transferrin Saturation, Dietary Iron Intake, and Risk of Cancer
Mainous, A. G. (2005) · The Annals of Family Medicine · doi:10.1370/afm.283 · Cited by 54 · see citing works
Heterotypic interactions between transferrin receptor and transferrin receptor 2
Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Björkman, P. J., & Enns, C. A. (2003) · Blood · doi:10.1182/blood-2002-09-2742 · Cited by 47 · see citing works
Kim, D., Kim, J. G., Cho, J. S., Baek, S. K., Kakar, S., Kim, G., Sleisenger, M. H., & Kim, Y. S. (2005) · International Journal of Oncology · doi:10.3892/ijo.27.4.957 · Cited by 39 · see citing works
Pelucchi, S., Mariani, R., Trombini, P., Coletti, S., Pozzi, M., Paolini, V., Barisani, D., & Piperno, A. (2009) · Haematologica · doi:10.3324/haematol.13576 · Cited by 35 · see citing works
Transferrin receptor 2 protein is not expressed in normal erythroid cells
Calzolari, A., Deaglio, S., Sposi, N. M., Petrucci, E., Morsilli, O., Gabbianelli, M., Malavasi, F., Peschle, C., & Testa, U. (2004) · Biochemical Journal · doi:10.1042/bj20040230 · Cited by 29 · see citing works
Self-citationClinical importance of late recurrence in soft-tissue sarcomas
Gibbs, J. F., Lee, R. J., Driscoll, D. L., McGrath, B. E., Mindell, E. R., & Kraybill, W. G. (2000) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(200002)73:2 · Cited by 27 · see citing works
Enríquez-Navascués, J. M., Díez, M., Tobaruela, E., Lozano, O., Dominguez, P. A., González, A., Mugüerza, J. M., & Ratia, T. (1998) · PubMed · Cited by 17 · see citing works
Two Subtypes of Mucinous Adenocarcinoma of the Colorectum: Clinicopathological and Genetic Features
Sarli, L., Bottarelli, L., Azzoni, C., Cola, G. D., Barilli, A. L., Costi, R., Mazzeo, A., Salvemini, C., Porrini, C., Cecchini, S., et al. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9950-x · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology
Brown, R. A. M., Richardson, K. L., Kabir, T. D., Trinder, D., Ganß, R., & Leedman, P. J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00476 · Cited by 279 · see citing works
Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268 · see citing works
“Moreover, the homologous TfR2 is also frequently upregulated in cancer cells [29,30].”
BackgroundTransferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas
Calzolari, A., Larocca, L. M., Deaglio, S., Finisguerra, V., Boe, A., Raggi, C., Ricci-Vitani, L., Pierconti, F., Malavasi, F., Maria, R. D., et al. (2010) · Translational Oncology · doi:10.1593/tlo.09274 · Cited by 131 · see citing works
Self-citationIntestinal Iron Homeostasis and Colon Tumorigenesis
Xue, X., & Shah, Y. M. (2013) · Nutrients · doi:10.3390/nu5072333 · Cited by 83 · see citing works
Adachi, M., Kai, K., Yamaji, K., Ide, T., Noshirο, H., Kawaguchi, A., & Aishima, S. (2019) · Histopathology · doi:10.1111/his.13847 · Cited by 81 · see citing works
Development and validation of a five-immune gene prognostic risk model in colon cancer
Chen, H., Luo, J., & Guo, J. (2020) · BMC Cancer · doi:10.1186/s12885-020-06799-0 · Cited by 79 · see citing works
Transferrin receptors and glioblastoma multiforme: Current findings and potential for treatment
Voth, B. L., Nagasawa, D. T., Pelargos, P. E., Chung, L. K., Ung, N. M., Gopen, Q. S., Tenn, S. E., Kamei, D. T., & Yang, I. (2015) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2015.02.002 · Cited by 76 · see citing works
The RNA-binding protein ESRP1 promotes human colorectal cancer progression
Fagoonee, S., Picco, G., Orso, F., Arrigoni, A., Longo, D. L., Forni, M., Scarfò, I., Cassenti, A., Piva, R., Cassoni, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14318 · Cited by 63 · see citing works
Self-citationSardoiwala, M. N., Kushwaha, A. C., Dev, A., Shrimali, N. M., Guchhait, P., Karmakar, S., & Choudhury, S. R. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01844 · Cited by 52 · see citing works
Osteosarcoma in Children: Not Only Chemotherapy
Argenziano, M., Tortora, C., Pota, E., Paola, A. D., Martino, M. D., Leva, C. D., Pinto, D., & Rossi, F. (2021) · Pharmaceuticals · doi:10.3390/ph14090923 · Cited by 47 · see citing works
Multicomponent Synthetic Polymers with Viral-Mimetic Chemistry for Nucleic Acid Delivery
Soliman, M. E., Nasanit, R., Abulateefeh, S. R., Allen, S., Davies, M. C., Briggs, S. S., Seymour, L. W., Preece, J. A., Grabowska, A. M., Watson, S. A., et al. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200108q · Cited by 43 · see citing works
Sasso, L., Purdie, L., Grabowska, A. M., Jones, A. T., & Alexander, C. (2018) · Journal of Interdisciplinary Nanomedicine · doi:10.1002/jin2.39 · Cited by 39 · see citing works
Banerjee, S. S., Jalota‐Badhwar, A., Satavalekar, S. D., Bhansali, S. G., Aher, N. D., Mascarenhas, R. R., Paul, D., Sharma, S., & Khandare, J. J. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200164 · Cited by 33 · see citing works
Iron Metabolism: State of the Art in Hypoxic Cancer Cell Biology
Liu, S., Cao, X., Wang, D., & Zhu, H. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109199 · Cited by 31 · see citing works
Multifaceted nature of membrane microdomains in colorectal cancer
Jahn, K. A. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i6.681 · Cited by 29 · see citing works
Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer
Elmorshedy, Y. M., Teleb, M., Sallam, M. A., Elkhodairy, K. A., Bahey-El-Din, M., Ghareeb, D. A., Abdulmalek, S. A., Monaim, S. A. H. A., Bekhit, A. A., Elzoghby, A. O., et al. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00037 · Cited by 28 · see citing works
Banerjee, S. S., Paul, D., Bhansali, S. G., Aher, N. D., Jalota‐Badhwar, A., & Khandare, J. J. (2012) · Small · doi:10.1002/smll.201102354 · Cited by 20 · see citing works
TFR2-Related Hereditary Hemochromatosis
Gobbi, M. D., & Roetto, A. (2011) · Institutional Research Information System University of Turin (University of Turin) · Cited by 12 · see citing works
Jin, T., Ge, L., Chen, J., Wang, W., Zhang, L., & Ge, M. (2023) · PeerJ · doi:10.7717/peerj.15592 · Cited by 8 · see citing works
Complete epigenomic and genomic analysis of transcriptome modulation within skin cutaneous melanoma
Xue, D., Cheng, P., Jiang, J., Ren, Y., Wu, D., & Chen, W. (2020) · Medical Science Monitor · doi:10.12659/msm.921133 · Cited by 8 · see citing works
Low expression of transferrin receptor 2 predict poor prognosis in gastric cancer patients
Zhao, Q., Ji, J. F., Cai, Q., Wang, C., Shi, M., Zhou, C., Zhu, Z., & Zhang, J. (2020) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12278 · Cited by 8 · see citing works
Sardoiwala, M. N., Sood, A., Biswal, L., Choudhury, S. R., & Karmakar, S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20990 · Cited by 7 · see citing works
Yang, Y., Du, J., Huang, Y., He, W., Liu, L.-Z., Li, D., & Chen, R. (2023) · Oncology Letters · doi:10.3892/ol.2023.14176 · Cited by 6 · see citing works
Li, J., Han, T., Wang, X., Wang, Y., Chen, X., Chen, W., & Yang, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.851373 · Cited by 4 · see citing works
Iron Vulnerability of Cancer Stem Cells
Nengroo, M. A., Sinha, A., & Datta, D. B. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_235 · Cited by 2 · see citing works
Iron, Cancer, and Hypoxia-Inducible Factor Signaling
Xue, X., & Shah, Y. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802168-2.00017-8
Iron Vulnerability of Cancer Stem Cells
Nengroo, M. A., Sinha, A., & Datta, D. B. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_235-1
Li, D., Jiang, C., Guan, Z.-A., Ma, L.-L., & Cui, W.-W. (2025) · Medicine · doi:10.1097/md.0000000000042729
Chen, H., Luo, J., & Guo, J. (2020) · Figshare · doi:10.6084/m9.figshare.12262538
Chen, H., Luo, J., & Guo, J. (2020) · Figshare · doi:10.6084/m9.figshare.12262544
Chen, H., Luo, J., & Guo, J. (2020) · Figshare · doi:10.6084/m9.figshare.12262541
- Authors
- Calzolari, A., Deaglio, S., Maldi, E., Cassoni, P., Malavasi, F., & Testa, U.
- Affiliations
- Istituto Superiore di Sanità (IT)
- University of Turin (IT)
- Corresponding author
- Testa, Ugo
- Venue
- Blood Cells Molecules and Diseases
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 43
- Issue
- 3
- Pages
- 243-249
- ISSN
- 1079-9796 (ISSN-L)
- OpenAlex
- W2079155774
- Cited by
- 32
- References
- 53
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood Cells Molecules and Diseases (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- transferrin receptor 2, colon cancer, iron homeostasis, iron metabolism, mucinous tumors, lipid rafts, ERK1/2 phosphorylation, transferrin, cell cycle, cancer cell growth, histological grade
- MeSH terms
- Carcinoma, Cell Cycle, Colonic Neoplasms, Humans, Iron, Receptors, Transferrin, Gene Expression Regulation, Neoplastic, Membrane Microdomains, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review