Cited by 32Iron Metabolism and DisordersFerroptosis and cancer prognosisGenetic factors in colorectal cancer

TfR2 expression in human colon carcinomas

Calzolari, Alessia, Deaglio, Silvia, Maldi, Elena, Cassoni, Paola, Malavasi, Fabio, Testa, Ugo·2009·Blood Cells Molecules and Diseases

Abstract

Different proteins regulate iron metabolism at the level of various tissues. Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis. Although TfR2 expression in normal tissues is restricted at the level of the liver, we observed that TfR2 is frequently expressed in cancer cell lines. Taking advantage of this observation we investigated TfR2 expression in primary colon cancers, and showed that this receptor is expressed in about 26% of cases. TfR2 expression in colon cancer is not related to histological grade, but is preferentially associated with mucinous tumors. In colon cancer cell lines, TfR2 is localized in membrane lipid rafts, induces ERK1/ERK2 phosphorylation, when activated by its ligand transferring, and is preferentially expressed during S-M phases of the cell cycle. The presence of TfR2 on the membrane of colon cancer cells may contribute the growth advantage to these cells.

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Crossref · 10.1016/j.bcmd.2009.08.001

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Authors
Calzolari, A., Deaglio, S., Maldi, E., Cassoni, P., Malavasi, F., & Testa, U.
Affiliations
  • Istituto Superiore di Sanità (IT)
  • University of Turin (IT)
Corresponding author
Testa, Ugo
Venue
Blood Cells Molecules and Diseases
Publisher
Elsevier BV
Published
2009-11
Volume
43
Issue
3
Pages
243-249
ISSN
1079-9796 (ISSN-L)
OpenAlex
W2079155774
Cited by
32
References
53
Citations by year
2025: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 2
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Blood Cells Molecules and Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
transferrin receptor 2, colon cancer, iron homeostasis, iron metabolism, mucinous tumors, lipid rafts, ERK1/2 phosphorylation, transferrin, cell cycle, cancer cell growth, histological grade
MeSH terms
Carcinoma, Cell Cycle, Colonic Neoplasms, Humans, Iron, Receptors, Transferrin, Gene Expression Regulation, Neoplastic, Membrane Microdomains, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases

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