Tsukamoto, Hidekazu

Alcoholic liver disease

Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 1,271

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 805

Peroxisome proliferator-activated receptors and hepatic stellate cell activation

Miyahara, T., Schrum, L., Rippe, R., Xiong, S., Yee, H. F., Motomura, K., Anania, F. A., Willson, T. M., & Tsukamoto, H. (2000) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 473

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

Mann, J., Chu, D. C. K., Maxwell, A., Oakley, F., Zhu, N., Tsukamoto, H., & Mann, D. A. (2010) · Gastroenterology

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 397

Inflammatory pathways in alcoholic steatohepatitis

Gao, B., Ahmad, M. F., Nagy, L. E., & Tsukamoto, H. (2019) · Journal of Hepatology

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 392

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A.-S., & Enns, C. A. (2009) · Cell Metabolism

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 326

Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

Chen, P., Torralba, M., Tan, J., Embree, M., Zengler, K., Stärkel, P., van Pijkeren, J.-P., DePew, J., Loomba, R., Ho, S. B., et al. (2015) · Gastroenterology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 322

Peroxisome Proliferator-activated Receptor γ Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells

Hazra, S., Xiong, S., Wang, J., Rippe, R. A., Krishna, V., Chatterjee, K., & Tsukamoto, H. (2004) · Journal of Biological Chemistry

Liver physiology and pathologyPeroxisome Proliferator-Activated Receptors

Cited by 320

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

Hartmann, P., Chen, P., Wang, H. J., Wang, L., McCole, D. F., Brandl, K., Stärkel, P., Belzer, C., Hellerbrand, C., Tsukamoto, H., et al. (2013) · Hepatology

Alcohol Consumption and Health EffectsGut microbiota and health

Cited by 246

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

Asahina, K., Tsai, S. Y., Li, P., Ishii, M., Maxson, R. E., Sucov, H. M., & Tsukamoto, H. (2009) · Hepatology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 238

Pyroptosis by caspase11/4‐gasdermin‐D pathway in alcoholic hepatitis in mice and patients

Khanova, E., Wu, R., Wang, W., Yan, R., Chen, Y., French, S. W., Llorente, C., Pan, S. Q., Yang, Q., Li, Y., et al. (2018) · Hepatology

Inflammasome and immune disordersAlcohol Consumption and Health Effects

Cited by 228

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Machida, K., Tsukamoto, H., Mkrtchyan, H., Duan, L., Dynnyk, A., Liu, H. M., Asahina, K., Govindarajan, S., Ray, R., Ou, J.-H. J., et al. (2009) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyAlcohol Consumption and Health Effects

Cited by 223

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

Ma, H.-Y., Yamamoto, G., Xu, J., Liu, X., Karin, D., Kim, J. Y., Alexandrov, L. B., Koyama, Y., Nishio, T., Benner, C., et al. (2020) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 216

Stearoyl-CoA desaturase promotes liver fibrosis and tumor development in mice via a wnt positive-signaling loop by stabilization of low-density lipoprotein-receptor-related proteins 5 and 6

Lai, K. K. Y., Kweon, S.-M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., et al. (2017) · Gastroenterology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 165

Signaling Role of Intracellular Iron in NF-κB Activation

Xiong, S., She, H., Takeuchi, H., Han, B., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., & Tsukamoto, H. (2003) · Journal of Biological Chemistry

NF-κB Signaling PathwaysIron Metabolism and Disorders

Cited by 161

Iron activates NF-κB in Kupffer cells

She, H., Xiong, S., Lin, M., Zandi, E., Giulivi, C., & Tsukamoto, H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology

NF-κB Signaling PathwaysIron Metabolism and Disorders

Cited by 121

Alcoholic hepatitis: Translational approaches to develop targeted therapies

Mandrekar, P., Bataller, R., Tsukamoto, H., & Gao, B. (2016) · Hepatology

Alcohol Consumption and Health EffectsLiver Disease and Transplantation

Cited by 115

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis

Montfort, C. V., Matias, N., Fernandez, A., Fucho, R., de la Rosa, L. C., Martinez-Chantar, M. L., Mato, J. M., Machida, K., Tsukamoto, H., Murphy, M. P., et al. (2012) · Journal of Hepatology

Redox biology and oxidative stressDrug-Induced Hepatotoxicity and Protection

Cited by 83

Iron-dependent activation of NF-κB in Kupffer cells: a priming mechanism for alcoholic liver disease

Xiong, S., She, H., Sung, C. K., & Tsukamoto, H. (2003) · Alcohol

Alcohol Consumption and Health EffectsIron Metabolism and Disorders

Cited by 82

Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis

Hyun, J., Sun, Z., Ahmadi, A. R., Bangru, S., Chembazhi, U. V., Du, K., Chen, T., Tsukamoto, H., Rusyn, I., Kalsotra, A., et al. (2020) · Journal of Clinical Investigation

Liver physiology and pathologyAlcohol Consumption and Health Effects

Cited by 76

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H., & Zhang, A.-S. (2013) · PLoS ONE

Iron Metabolism and DisordersTrace Elements in Health

Cited by 69

PPAR Gamma and Hepatic Stellate Cells

Hazra, S., Miyahara, T., Rippe, R. A., & Tsukamoto, H. (2004) · Comparative Hepatology

Liver physiology and pathologyPeroxisome Proliferator-Activated Receptors

Cited by 66

Iron Causes Interactions of TAK1, p21ras, and Phosphatidylinositol 3-Kinase in Caveolae to Activate IκB Kinase in Hepatic Macrophages

Chen, L., Xiong, S., She, H., Lin, S. W., Wang, J., & Tsukamoto, H. (2007) · Journal of Biological Chemistry

Caveolin-1 and cellular processesNF-κB Signaling Pathways

Cited by 64

Tumor necrosis factor-α inhibits peroxisome proliferator-activated receptor γ activity at a posttranslational level in hepatic stellate cells

Sung, C. K., She, H., Xiong, S., & Tsukamoto, H. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 63