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Cited by 182

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance

Open access
Chavey, Carine, Lazennec, Gwendal, Lagarrigue, Sylviane, Clapé, Cyrielle, Iankova, Irena, Teyssier, Jacques, Annicotte, Jean-Sébastien, Schmidt, Julien, Mataki, Chikage, Yamamoto, Hiroyasu, Sanches, Rosario, Guma, Anna, Stich, Vladimir, Vitkova, Michaela, Jardin-Watelet, Bénédicte, Renard, Eric, Strieter, Robert, Tuthill, Antoinette, Hotamisligil, Gôkhan S., Vidal-Puig, Antonio, Zorzano, Antonio, Langin, Dominique, Fajas, Lluis·2009·Cell Metabolism
DOI 10.1016/j.cmet.2009.03.002
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Abstract

We show here high levels of expression and secretion of the chemokine CXCL5 in the macrophage fraction of white adipose tissue (WAT). Moreover, we find that CXCL5 is dramatically increased in serum of human obese compared to lean subjects. Conversely, CXCL5 concentration is decreased in obese subjects after a weight reduction program, or in obese non-insulin resistant, compared to insulin resistant obese subjects. Most importantly we demonstrate that treatment with recombinant CXCL5 blocks insulin-stimulated glucose uptake in muscle in mice. CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway. Finally, by treating obese, insulin resistant mice with either anti-CXCL5 neutralizing antibodies or antagonists of CXCR2, which is the CXCL5 receptor we demonstrate that CXCL5 mediates insulin resistance. Furthermore CXCR2−/− mice are protected against obesity-induced insulin resistance. Taken together, these results show that secretion of CXCL5 by WAT resident macrophages represents a link between obesity, inflammation, and insulin resistance.

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Metadata

Authors
Chavey, C., Lazennec, G., Lagarrigue, S., Clapé, C., Iankova, I., Teyssier, J., Annicotte, J.-S., Schmidt, J., Mataki, C., Yamamoto, H., Sanches, R., Guma, A., Stich, V., Vitkova, M., Jardin-Watelet, B., Renard, E., Strieter, R., Tuthill, A., Hotamisligil, G. S., Vidal-Puig, A., Zorzano, A., Langin, D., & Fajas, L.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2009-04
Volume
9
Issue
4
Pages
339-349
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2009.03.002
OpenAlex
W2034541077
Cited by
182
References
12
FWCI
6.99
Type
journal article
Language
en
Open access
bronze

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The paper
Chavey, C., Lazennec, G., Lagarrigue, S., Clapé, C., Iankova, I., Teyssier, J., Annicotte, J.-S., Schmidt, J., Mataki, C., Yamamoto, H., Sanches, R., Guma, A., Stich, V., Vitkova, M., Jardin-Watelet, B., Renard, E., Strieter, R., Tuthill, A., Hotamisligil, G. S., . . . Fajas, L. (2009). CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.03.002

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.