Do cancer cells care if their host is hungry?

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works

Insulin and insulin-like growth factor signalling in neoplasia

Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059 · see citing works

Tumor suppressors and cell metabolism: a recipe for cancer growth

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Tumours with PI3K activation are resistant to dietary restriction

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Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

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Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

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The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

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Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

Algire, C., Zakikhani, M., Blouin, M.-J., Shuai, J. H., & Pollak, M. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0038 · Cited by 185 · see citing works

Association of Diet-Induced Hyperinsulinemia With Accelerated Growth of Prostate Cancer (LNCaP) Xenografts

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Dietary Energy Restriction Modulates the Activity of AMP-Activated Protein Kinase, Akt, and Mammalian Target of Rapamycin in Mammary Carcinomas, Mammary Gland, and Liver

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A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model

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Diabetes and Cancer

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Nutrition and physical activity guidelines for cancer survivors

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American Cancer Society guidelines on nutrition and physical activity for cancer prevention

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Diabetes and Cancer: A Consensus Report

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Cancer Risk Among People With Type 1 and Type 2 Diabetes: Disentangling True Associations, Detection Bias, and Reverse Causation

Harding, J. L., Shaw, J. E., Peeters, A., Cartensen, B., & Magliano, D. J. (2014) · Diabetes Care · doi:10.2337/dc14-1996 · Cited by 288 · see citing works

Diabetes and cancer: two diseases with obesity as a common risk factor

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Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

Johnson, J. A., Carstensen, B., Witte, D. R., Bowker, S. L., Lipscombe, L. L., & Renehan, A. G. (2012) · Diabetologia · doi:10.1007/s00125-012-2525-1 · Cited by 258 · see citing works

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

Pollak, M. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0175 · Cited by 240 · see citing works

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

Algire, C., Amrein, L., Zakikhani, M., Panasci, L., & Pollak, M. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0252 · Cited by 234 · see citing works

Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?

Klil-Drori, A. J., Azoulay, L., & Pollak, M. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.120 · Cited by 207 · see citing works

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

Algire, C., Amrein, L., Bazile, M., David, S., Zakikhani, M., & Pollak, M. (2010) · Oncogene · doi:10.1038/onc.2010.483 · Cited by 181 · see citing works

A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose

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Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats

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Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

Phoenix, K. N., Vumbaca, F., Fox, M. M., Evans, R., & Claffey, K. P. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0647-z · Cited by 97 · see citing works

Diabetes mellitus: influences on cancer risk

Szablewski, L. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2573 · Cited by 67 · see citing works

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Johnson, J. A., & Pollak, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1855-0 · Cited by 45 · see citing works

Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer

Bishayee, A., Mandal, A., Thoppil, R. J., Darvesh, A. S., & Bhatia, D. (2013) · International Journal of Cancer · doi:10.1002/ijc.28108 · Cited by 43 · see citing works

Using genetics to decipher the link between type 2 diabetes and cancer: shared aetiology or downstream consequence?

Vincent, E. E., & Yaghootkar, H. (2020) · Diabetologia · doi:10.1007/s00125-020-05228-y · Cited by 41 · see citing works

Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

Parrado‐Fernández, C., López‐Lluch, G., Rodríguez-Bies, E., Calvo, S. S.-C., Navas, P., Ramsey, J. J., & Villalba, J. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.024 · Cited by 36 · see citing works

Colorectal cancer, diabetes and survival: Epidemiological insights

Zanders, M. M. J., Vissers, P. A. J., Haak, H. R., & van de Poll-Franse, L. V. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.12.007 · Cited by 34 · see citing works

IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer

Dool, C. J., Mashhedi, H., Zakikhani, M., David, S., Zhao, Y., Birman, E., Carboni, J. M., Gottardis, M. M., Blouin, M., & Pollak, M. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0136 · Cited by 33 · see citing works

Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis

Ali, F. D. R., Khan, R., Khan, A. Q., Lateef, M. A., Maqbool, T., & Sultana, S. (2013) · Integrative Cancer Therapies · doi:10.1177/1534735413513831 · Cited by 20 · see citing works

Diabetes and cancer: Debating the link through Ca2+/cAMP signalling

Bergantin, L. B. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.02.017 · Cited by 19 · see citing works

Aldehyde dehydrogenase 1 a1 regulates energy metabolism in adipocytes from different species

Yang, K., Adin, C. A., Shen, Q., Lee, L. J., Yu, L., Fadda, P., Samogyi, A., Ham, K., Xu, L., Gilor, C., et al. (2017) · Xenotransplantation · doi:10.1111/xen.12318 · Cited by 18 · see citing works

Metformin and asarone inhibit HepG2 cell proliferation in a high glucose environment by regulating AMPK and Akt signaling pathway

Das, B. K., Knott, R. M., & Gadad, P. C. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00193-8 · Cited by 17 · see citing works

CRITICAL REVIEW IN PHARMACEUTICAL SCIENCES

publisher, P. E. (2014) · ADVANCED SCIENCES INDEX · Cited by 16 · see citing works

Obesity-related gut hormones and cancer: novel insight into the pathophysiology

Guzzardi, M. A., Pugliese, G., Bottiglieri, F., Pelosini, C., Muscogiuri, G., Barrea, L., Savastano, S., & Colao, A. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00865-8 · Cited by 15 · see citing works

Type 2 Diabetic Mellitus Is a Risk Factor for Nasopharyngeal Carcinoma: A 1:2 Matched Case–Control Study

Peng, X., Xie, G., Qiu, W., Tian, Y., Zhang, W., & Cao, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165131 · Cited by 13 · see citing works

Defining the Role of Histone Deacetylases in the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction (DER): Effects of Suberoylanilide Hydroxamic Acid (SAHA) and DER in a Rat Model

Zhu, Z., Jiang, W., McGinley, J. N., & Thompson, H. J. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0449-t · Cited by 8 · see citing works

Diabetes, diabetes therapies and cancer: what’s the link?

Seewoodhary, J., & Bain, S. C. (2011) · The British Journal of Diabetes · doi:10.1177/1474651411421024 · Cited by 7 · see citing works

Cancer du sein et diabète de type 2 : des interactions complexes

Bernard, L., Reix, N., Benabu, J.-C., Gabriele, V., & Mathelin, C. (2016) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2016.09.004 · Cited by 7 · see citing works

Macronutrient Intake and Cancer: How Does Dietary Restriction Influence Tumor Growth and Why Should We Care?

Pollak, M. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0134 · Cited by 6 · see citing works

ANGIOGENESIS MODULATES OBESITY AND INSULIN SENSITIVITY

Honek, J. (2014) · Figshare

Type 2 diabetes mellitus and gastrointestinal cancer

de Jong (2019) · doi:10.26481/dis.20190605rj

Diabetes with Pancreatic Ductal Adenocarcinoma

Srivani, G., Dariya, B., Alam, A., & Nagaraju, G. P. (2019) · Springer eBooks · doi:10.1007/978-981-32-9393-9_7

Diabetes and Cancer: Treacherous Associations

Saxena, R., Naithani, M., & Saluja, R. (2022) · Journal of Cardio-diabetes and metabolic disorders · doi:10.4103/jcdm.jcdm_9_21

Data from Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

Pollak, M. (2023) · doi:10.1158/1940-6207.c.6544304.v1

Diabetes and colorectal cancer : epidemiological and physiopathological studies

Mroueh, F. M. (2017) · doi:10.70675/65c64643z9facz43ddz8889z715719c5dcb8

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer

Klement, R. J., & Fink, M. K. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.2 · Cited by 115 · see citing works

Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.

Kari, F. W., Dunn, S. E., French, J. E., & Barrett, J. C. (1999) · PubMed · Cited by 88 · see citing works

ORAL PRESENTATION Open Access Can

Fine, E. J., Segal-Isaacson, C. J., Herzkopf, S., Sparano, J. A., Romano, M., Feinman, R., Tomuta, N., Bontempo, A., & Negassa, A. (2016)

Insulin Does Not Augment In Vitro Tumor Growth Under A Hyperglycemia-Mimicking Milieu And In A Calorie Restriction-Resembling MannerPreprint

Liao, T., Li, X., Chen, Y., Tan, L.-L., Zhang, J., Huang, X., Xu, Q., Huang, S.-Q., Li, C., & Zeng, Q.-P. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/169664

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

Dunn, S. E., Kari, F. W., French, J. E., Leininger, J. R., Travlos, G. S., Wilson, R., & Barrett, J. C. (1997) · PubMed · Cited by 439 · see citing works