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MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
Open accessAbstract
Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxic cell type, we identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210 (miR-210). ISCU1/2 facilitate the assembly of iron-sulfur clusters, prosthetic groups that are critical for electron transport and mitochondrial oxidation-reduction reactions. Under in vivo conditions of upregulating miR-210 and repressing ISCU1/2, the integrity of iron-sulfur clusters is disrupted. In turn, by repressing ISCU1/2 during hypoxia, miR-210 decreases the activity of prototypical iron-sulfur proteins controlling mitochondrial metabolism, including Complex I and aconitase. Consequently, miR-210 represses mitochondrial respiration and associated downstream functions. These results identify important mechanistic connections among microRNA, iron-sulfur cluster biology, hypoxia, and mitochondrial function, with broad implications for cellular metabolism and adaptation to cellular stress.
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“The coordinate metabolic changes caused by HIF-1 that alter mitochondrial function are attributable, in part, to the HIF-1-mediated transcriptional upregulation of microRNA 210 (miR210), which specifically inhibits Fe-S complex formation to alter mitochondrial bioenergetics and ROS production (Pasteur effect) (69).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [69]
In the citing paper
“Interestingly, during normoxia, forced expression of miR210 caused an increase in ROS generation (69, 81), possibly due to deficiencies in complex I that may promote electron leak in the presence of molecular oxygen.”
From Redox regulation of mitochondrial function (2012) · cites this paper as [69]
In the citing paper
“Nonetheless, experimental evidence suggests that enhanced ROS production is not a sustained event in hypoxia (69, 385).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [69]
In the citing paper
“Within mitochondria it targets regulatory proteins that assist in the assembly of the complexes of the electron transport chain, and suppresses respiration (103, 108).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [103]
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1 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601 · cited 1×
“Mitophagy has been characterized as a HIF-dependent mechanism (Zhang et al., 2008).”
BackgroundRetractedKim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · cited 1×
“First, by induction of PDK1, HIF-1a decreases the activity of the TCA cycle, increases glycolysis, and reduces mitochondrial electron flux (Kim et al., 2006).”
Iron-sulfur clusters: nature's modular, multipurpose structures
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InfluentialHIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
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“Second, HIF-1a induces a COX4-1 to COX4-2 subunit switch during hypoxia to improve the efficiency of electron transfer to oxygen at Complex IV (Fukuda et al., 2007).”
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · cited 1×
“Conditions were based on studies of hypoxic exposure of HPAECs (Manalo et al., 2005) to allow for steady-state adaptation without nonspecific cell death.”
A MicroRNA Signature of Hypoxia
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“…with other studies demonstrating the repression of apoptosis by miR-210 during hypoxia in other cellular contexts (Fasanaro et al., 2008; Kulshreshtha et al., 2007), these data lend credence to a model in which miR-210 carries a maladaptive role during normoxia, causing a mismatch of…”
InfluentialHypoxia-Induced Pulmonary Vascular Remodeling
Stenmark, K. R., Fagan, K. A., & Frid, M. G. (2006) · Circulation Research · doi:10.1161/01.res.0000243584.45145.3f · Cited by 1,001 · cited 2×
“In particular, this response may be especially important to the pulmonary vascular endothelium, which directly responds to hypoxia by controlling the release of vasoactive effectors, thereby critically influencing normal vascular physiology and the development of pulmonary hypertension (Stenmark et al., 2006).”
Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912 · cited 6×
“Some, but not all, of these miRNA have been identified in other transformed (Kulshreshtha et al., 2007) or primary endothelial cells (Fasanaro et al., 2008) exposed to hypoxia.”
Influentialhsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
Camps, C., Buffa, F. M., Colella, S., Moore, J., Sotiriou, C. P., Sheldon, H., Harris, A. L., Gleadle, J., & Ragoussis, J. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1755 · Cited by 672 · cited 3×
“Additionally, miR-210 is specifically induced by HIF-1a but not HIF-2a (Camps et al., 2008), a second transcriptional regulator of the hypoxic response, which carries partial but not full redundancy in function with HIF-1a (Wang et al., 2005).”
Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells
Seagroves, T. N., Ryan, H. E., Lu, H., Wouters, B. G., Knapp, M., Thibault, P., Laderoute, K. R., & Johnson, R. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3436-3444.2001 · Cited by 634 · cited 4×
“The elucidation of the miR-210-ISCU1/2 regulatory pathway substantially clarifies the nature of the complex crosstalk between HIF-1a and mitochondria (Seagroves et al., 2001) and complements other HIF-dependent processes proposed to regulate the mismatch of reduced oxygen tension and mitochondrial electron transport.”
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Items 501–600 of 702
Indole‐3‐carbinol ameliorated the neurodevelopmental deficits in neonatal anoxic injury in rats
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“Furthermore, HIF-1α levels sustained during the secondary injury can further aggravate mitochondrial dysfunction, reactive oxygen species (ROS) generation, and apoptosis (Cai et al., 2019; Chan et al., 2009; Fan et al., 2009; Guo et al., 2001; Kim et al., 2006; Moulis et al., 2017; Semenza, 2011).”
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“Although human mutations in Fe-S biogenesis genes are rare, the importance of this pathobiology should not be underestimated, particularly considering that Fe-S deficiency can also be driven by acquired exposures (such as hypoxia) (9, 11) and likely is prevalent, in general, across multiple subtypes of PH.”
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“However, cells exposed to a hypoxic environment activate HIF-1α dependent transcriptional targets, in turn inhibiting ROS production [35, 36].”
BackgroundParacrine effects of mir-210-3p on angiogenesis in hypoxia-treated c-kit-positive cardiac cells
Shen, L., Fan, G., Yang, G., Yang, Z., & Gui, C. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2237690 · Cited by 9
[Progress on epigenetic regulation of iron homeostasis].
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MitomiRs Keep the Heart Beating
Das, S., Vasanthi, H. R., & Parjapath, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_23 · Cited by 9
Meruvu, S., Ding, Z., & Choudhury, M. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100188 · Cited by 9
“MiR-210-3p exerts this role by directly inhibiting key genes of the electron transport chain such as Iron-sulfur cluster assembly enzyme and Cytochrome c oxidase 10 (Chan et al., 2009; Chen et al., 2010).”
BackgroundMitra, A., Yi, D., Dai, Z., & Pérez, V. D. J. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1460376 · Cited by 8
miR-210 overexpression increases pressure overload-induced cardiac fibrosis
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Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape
Flores, C. V., & Chan, S. Y. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2507034 · Cited by 8
“MicroRNA-210 (miR-210) plays a pathogenic role in PAH, primarily through disrupting iron – sulfur (Fe-S) cluster bio-genesis, leading to metabolic dysfunction and pulmonary vascular remodeling [68,69].”
Self-citationMicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy
De, A., Sarkar, A., Banerjee, T., Bhowmik, R., Sar, S., Shaharyar, M. A., Karmakar, S., & Ghosh, N. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1613844 · Cited by 9
Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension
Kim, Y., Maroli, G., Woodcock, C.-. C., Kim, H., Liu, Y., Klouda, T., Li, Y., Li, Q., Hao, Y. T., Schumacher, V., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.326235 · Cited by 8
Self-citationMicroRNA-210 knockdown contributes to apoptosis caused by oxygen glucose deprivation in PC12 cells
Qiu, J., Xiao-yu, Z., Zhou, X., Li, Y., Cheng, R., & LIU, H.-Y. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2651 · Cited by 8
“In particular, microRNA-210 (miR-210), which is activated by the transcriptional factor hypoxia inducible factor-1α (HIF-1α) (3), is a unique miR that is evolutionarily conserved and ubiquitously expressed in a number of hypoxic cell and tissue types (4-10).”
Shen, J., Xu, L., Li, Y., Dong, W., Cai, J., Liu, Y., Zhao, H., Xu, T., Meyron‐Holtz, E. G., Chang, Y., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.715222 · Cited by 8
“The rationale for Hif2α to regulate IscU has been demonstrated in which IscU is a member of the miR-210 regulon (Chan et al., 2009) and the promoter of miR-210 contains a HRE for Hif1/2 binding (Kulshreshtha et al.”
Lai, N., Kummitha, C., Loy, F., Isola, R., & Hoppel, C. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-62370-8 · Cited by 8
Oxidation Impacts the Intracellular Signaling Machinery in Hematological Disorders
Tibaldi, E. V., Federti, E., Mattè, A., Iatcenko, I., Wilson, A. B., Riccardi, V., Pagano, M. A., & Franceschi, L. D. (2020) · Antioxidants · doi:10.3390/antiox9040353 · Cited by 9
“A HIF-1α-mediated mechanism countering oxidative stress is known to rely on the decrease of mitochondrial complex I activity by both inducing transcription of miRNAs that repress the expression of the iron–sulfur cluster assembly protein ISCU1/2 [72] and fostering expression of NDUFA4L2, thereby reducing oxygen consum…”
BackgroundHu, S. X., Lopez-Robles, Y., Shen, G., Liu, E., Zhang, L., & Ma, Q. (2025) · Cells · doi:10.3390/cells14151202 · Cited by 7
“Consequently, the inhibition of the activity of ETC subunits, especially ISCU, leads to mitochondrial dysfunction and cell death [25,26,39–42].”
Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension
Woodcock, C.-. C., Maroli, G., Kim, H., Tai, Y., Tang, Y. M., Okawa, S., Homsi, R., Kim, Y., Cho, S., Jiang, S., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.326277 · Cited by 7
Self-citationZhang, Y., Yang, S., Xiang, Q., Huang, J., Tan, Y., Peng, X., Feng, Y., Chang, R., Li, J., Cheng, Y., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.202520859 · Cited by 7
Self-citationHypoxia, ROS, and HIF Signaling in I/R Injury: Implications and Future Prospects
Singh, M. K., Yun, H. R., Ranbhise, J. S., Han, S., Kim, S. S., & Kang, I. (2026) · Antioxidants · doi:10.3390/antiox15020153 · Cited by 9
“During hypoxia, HIF-1 α induces miR-210, which targets mitochondrial genes iron-sulfur cluster enzyme 1/2 (ISCU1/2) (Figure 3) [90], thereby reducing the activity of iron-sulfur-dependent enzymes, such as aconitase and mitochondrial complex 1 [91].”
Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review)
Li, Y., Wei, Y., Guo, J., Cheng, Y., & He, W. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3007 · Cited by 7
Crosstalk between hypoxia and inflammation in non-Hodgkin lymphoma
Pangarsa, E. A., Rizky, D., Setiawan, B., Santosa, D., Haryana, S. M., & Suharti, C. (2022) · Bali Medical Journal · doi:10.15562/bmj.v11i3.3491 · Cited by 6
Wang, J., Kuang, J., Zhang, S., Liu, Z., Guo, Q., Li, S., Qiu, L., Fu, G., Lin, X., Wu, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108815 · Cited by 7
“45 In our data, miR-210 was upregulated not only in lung tissue but also in heart and brain tissue (Table S3).”
BackgroundSelf-citationDing, X., Yang, C., Bao, P., Wu, X., Pei, J., Yan, P., & Guo, X. (2018) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.17.0706 · Cited by 8
“However, nature of the interaction between HIF-1α and aerobic metabolism is still incompletely understood [14], thus we hypothesized that additional factors likely mediate the fundamental metabolic events of high altitude adaptations in yak.”
BackgroundFrataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
Culley, M. K., Rao, R. J., Mehta, M., Zhao, J., Khoury, W. E., Harvey, L. D., Perk, D., Tai, Y., Tang, Y., Shiva, S., et al. (2022) · Vascular Pharmacology · doi:10.1016/j.vph.2023.107181 · Cited by 8
Self-citationLang, L., Xu, B., Li, S., Guo, W., Yuan, J., Zang, S., Chen, Y., Yang, H., & Lian, S. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13100 · Cited by 7
Effects of hypoxic‑ischemic pre‑treatment on microvesicles derived from endothelial progenitor cells
Zeng, W., Lei, Q., Ma, J., & Ju, R. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8468 · Cited by 7
“A diverse range of genes have been demonstrated to be direct targets of miR-210, including iron‐sulfur cluster assembly protein ISCU1/2, fibroblast growth factor receptor-like 1, FLASH/caspase-8 associated protein-2, HOXA3, RAD52 homolog, DNA repair protein and tyrosine kinase ligand ephrin-A3 (41,44-48).”
MicroRNA-210 Regulates Endoplasmic Reticulum Stress and Apoptosis in Porcine Embryos
Ridlo, M. R., Kim, E. H., & Kim, G. A. (2021) · Animals · doi:10.3390/ani11010221 · Cited by 7
“MiR-210 impairs mitochondrial function, increases glycolysis, and triggers the generation of reactive oxygen species (ROS) [29,30].”
BackgroundResultInfluentialCell size dependent migration of T-cells latently infected with HIV
Timón‐Gómez, A., & Barrientos, A. (2020) · JoLS Journal of Life Sciences · doi:10.36069/jols/20200601 · Cited by 8
miRNAs involved in the regulation of exercise fatigue
Niu, S., Yin, X., Cao, Q., Huang, K., Deng, Z., & Cao, J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1614942 · Cited by 6
Crosstalk between miRNAs and oxidative stress: implications for cancer pathogenesis and therapy
Mansour, R. M., Hemdan, M., Alam-ElDein, K. M., Sallam, A.-A. M., Elimam, H., Elazazy, O. E., Mageed, S. S. A., Mohammed, O. A., Rizk, N. I., Abdelaziz, M. M., et al. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01737-4 · Cited by 8
“Under hypoxic conditions, cancer cells rely on specific miRNAs to adapt and survive. miR-210 is a key regulator induced by HIF-1α, which represses iron–sulfur cluster assembly proteins ISCU1/2, impairing mitochondrial respiration and reducing ROS production (Chan et al. 2009).”
Guo, K., Gong, J., Zhong, W., Zhang, Y. J., Xu, Y., Hao, Y., Xu, Z., Ma, L., Chen, J., Shi, Y., et al. (2026) · Research · doi:10.34133/research.1248 · Cited by 6
Self-citationGomes, J., Mendes‐Ferreira, P., Adão, R., Maia-Rocha, C., Rego, B., Poels, M., Willer, A. S., Masson, B., Provencher, S., Bonnet, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158054 · Cited by 6
“Circulating levels of miR-146a are increased in patients with coronary arterial disease [22], and miR-146a is overexpressed in the RV [23] and PA endothelial cells (PAECs) under hypoxic conditions [24].”
BackgroundImplication of microRNAs as messengers of exercise adaptation in junior female triathlonists
Gaál, Z., Fodor, J., Oláh, T., Szabo, I., Balatoni, I., & Csernoch, L. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-73670-8 · Cited by 6
“…with its well-established role in cellular responses to hypoxia including a transient metabolic shift to anaerobic glycolysis and lactate production 9,10 , the observed increment of miR-210 expression in whole blood samples of athletes suggests an acute impact of miR-210 on metabolism following…”
Use of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds
Sumpio, B. J., Dallas, A., Berger, A. G., Li, Z., Wang, E., Mezghani, I., Contreras, M., Theocharidis, G., Ilves, H., Hammond, P. T., et al. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0056 · Cited by 7
“17,20,21 The other important concept that this study supports is that LbL can be an effective formulation approach for packaging and localized release of various RNA oligonucleotide therapies.”
miR-210 promotes immune- and suppresses oocyte meiosis-related genes in the zebrafish ovarian cells
van Gelderen, T. A., & Ribas, L. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110820 · Cited by 7
MiR210 in neonatal hypoxic-ischemic encephalopathy
Ma, Q., & Zhang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.14766 · Cited by 6
The Role of MicroRNAs in Liver Functioning: from Biogenesis to Therapeutic Approaches (Review)
Kozlov, D., Rodimova, S. A., & Kuznetsova, D. S. (2023) · Современные технологии в медицине · doi:10.17691/stm2023.15.5.06 · Cited by 6
miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages
Neculachi, C. A., Nastase-Rusu, E.-G., Cherry, L., Marinescu-Colan, C. I., Tastsoglou, S., Cosman, B., Popa, A. M., Panciuc, C., Zaccagnini, G., Catrina, S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1633163 · Cited by 5
“MiR-210 regulates genes associated with glycolysis and oxidative phosphorylation, which are both essential for macrophage activation and polarization (11 – 15).”
Gokce, M., Bektay, M. Y., Uzun, M., Ulutaş, C., Uslu, F. İ., & Güler, E. M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07055-4 · Cited by 5
The Role of Mitochondria in Obstructive Sleep Apnea: Implications for the Upper Airway Muscles
Carlos, K., do Prado, G. F., & Tengan, C. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110562 · Cited by 5
miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells
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Self-citationAbalenikhina, Y. V., Mylnikov, P. Y., Shchulkin, A. V., Chernykh, I. V., & Yakusheva, E. N. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05540-0 · Cited by 5
“For example, HIF-1 suppresses mitochondrial respiration and activity of the electron transport chain by activating the transcription of miR-201 microRNA, which reduces the expression of iron and sulfur cluster assembly proteins ISCU1/2 and NDUFA4L2, thereby reducing activity of the complex I [5].”
BackgroundGorący, A., Rosik, J., Szostak, J., Szostak, B., Retfiński, S., Machaj, F., & Pawlik, A. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2240021 · Cited by 5
Inverse correlation between heme synthesis and the Warburg effect in cancer cellsPreprint
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Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders
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MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb
Hu, X., Song, R., Dasgupta, C., Twum‐Barimah, S., Liu, T., Ahmed, A. S. I., Hanson, S. F. L., Zhang, L., & Blood, A. B. (2025) · Hypertension · doi:10.1161/hypertensionaha.124.23061 · Cited by 4
“56 59 Of importance, we demonstrated that knockdown of ISCU by ISCU siRNAs recapitulated the effects of hypoxia and microRNA-210 by suppressing STOCs in newborn pulmonary arteries.”
Non-Coding RNA Networks in Pulmonary Arterial Hypertension
Chen, B., Xia, Y., Jiang, Y., Sun, Z., Zhang, Y., & Liu, Y. (2024) · Pharmacology · doi:10.1159/000541060 · Cited by 4
“This disruption leads to oxidative stress and pulmonary vascular proliferation [53, 54].”
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“05 C282Y/C282Y 81 [45-89]; 14 55 [35-89]; 11 NS C282Y/H63D 51 [31-59]; 6 19 [14-42]; 5 0.”
Feng, X., Zhang, L., Feng, W., Zhang, C., Jin, T., Li, J., & Guo, J. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17250 · Cited by 4
Pathogenic and Therapeutic Role of MicroRNA in Pulmonary Arterial Hypertension
Babicheva, A., McDermott, K. M., Williams, S. C., Yee, A. M., Dash, S., Rodriquez, M., Ingabire, N., Makino, A., & Yuan, J. X. ‐. (2017) · Springer eBooks · doi:10.1007/978-981-287-840-3_3 · Cited by 4
Loncaric, D., Stanković, B., Ghousein, A., Vreća, M., Spasovski, V., Villacreces, A., Debeissat, C., Grosset, C. F., Ivanović, Z., & Pavlović, S. (2019) · Archives of Biological Sciences · doi:10.2298/abs181117001l · Cited by 4
“It is also involved in the regulation of cell cycle and apoptotic cell death, as well as in the HIF-1α protein stability, which is the first response of a cell exposed to low partial pressure of oxygen [34,41,43-46].”
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Therapeutic Potential of Modulating Gene-MicroRNA Crosstalk in Burn Injury
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Genetic Instability Induced by Hypoxic Stress
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Redox Pioneer: Professor Joseph Loscalzo
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“Studies have reported that miR-210 has a negative effect on mitochondrial respiration with direct targets including Iscu1/2 and Cox10 , which are important factors in the mitochondrial electron transport chain [48–51].”
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Emerging Roles of Non-Coding RNAs in the Hypoxic Response
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Regulation of Gene Transcription by Hypoxia-Inducible Factor 1
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Transcription | Regulation of Gene Transcription by Hypoxia-Inducible Factor 1α
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Deficits in mitochondrial dynamics and iron balance result in templated insertions
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“These miRNAs are related to extracellular matrix remodeling, lipids metabolism, and hypoxia response, respectively (Chan et al., 2009; Van Rooij et al., 2008).”
MicroRNAs and Cancer Metabolism
Gao, P. (2010) · Springer eBooks · doi:10.1007/978-94-007-0298-1_20 · Cited by 2
“Using human pulmonary arterial endothelial cells (HPAEC), in which robust up-regulation of miR-210 in response to hypoxia was reported, Chan et al. (2009) identified ISCU1/2 as direct targets for repression by miR-210.”
Role of succinate dehydrogenase in hepatocellular carcinoma
Srivani, G., Imran, M., Merchant, N., Mandala, J. P., & Nagaraju, G. P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98806-3.00014-3 · Cited by 2
Oxidative Stress Modulation with MicroRNAs in Cancers
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“Ren et al. demonstrated that ISCU promotes tumor growth by facilitating the metabolism of α-ketoglutarate catabolism and an increase in DNA 5mC [30], while Chan et al. found that MicroRNA-210 improves mitochondrial metabolism during hypoxia by inhibiting ISCU1/2 [31].”
miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study
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“Our study demonstrates that the loss of miR-210 locus leads to reduced cellular fitness, a finding consistent with previous experiments involving miR-210 antagonists 8–10 .”
Stem cells telomerase regulation and the hypoxic state
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“This proliferation occurs even though miR-210 represses the mitochondrial iron-sulfur cluster assembly proteins essential for tricarboxylic acid cycle enzyme aconitase and electron transport chain complex I (33).”
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MitomiRs in Human Inflamm-aging
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Self-citation
Metadata
- Authors
- Chan, S. Y., Zhang, Y.-Y., Hemann, C., Mahoney, C. E., Zweier, J. L., & Loscalzo, J.
- Affiliations
- Harvard University (US)
- The Ohio State University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Loscalzo, Joseph
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 10
- Issue
- 4
- Pages
- 273-284
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2759401
- OpenAlex
- W2087408461
- Cited by
- 702
- References
- 37
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 30 · 2023: 24 · 2022: 45 · 2021: 73 · 2020: 44 · 2019: 50 · 2018: 29 · 2017: 51 · 2016: 35 · 2015: 38 · 2014: 59 · 2013: 60 · 2012: 39
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hv28178-12-0-0)
- U.S. Public Health Service (P01 81587)
- National Heart, Lung, and Blood Institute (HL61795, K08HL096834, U54HL070819, P01HL081587, N01-HV-028178, R21HL089734, R01HL061795, R37HL061795)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
- Keywords
- miR-210, iron-sulfur cluster assembly, hypoxia, mitochondrial metabolism, mitochondrial respiration, pulmonary artery endothelial cells, complex I, aconitase, iron-sulfur proteins
- MeSH terms
- Animals, Hypoxia, Cells, Cultured, Gene Expression Regulation, Humans, Iron-Sulfur Proteins, Mitochondria, Oxygen Consumption, Mice, Knockout, MicroRNAs, Endothelial Cells, Mice, Von Hippel-Lindau Tumor Suppressor Protein, Caspase 3, Caspase 7
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