Loscalzo, Joseph

Network medicine: a network-based approach to human disease

Barabási, A.-L., Gulbahce, N., & Loscalzo, J. (2011) · Nature Reviews Genetics

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 5,034

Biochemistry of nitric oxide and its redox-activated forms

Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 2,744

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 2,433

Homocysteine and Atherothrombosis

Welch, G. N., & Loscalzo, J. (1998) · New England Journal of Medicine

Folate and B Vitamins ResearchMetabolism and Genetic Disorders

Cited by 1,997

Uncovering disease-disease relationships through the incomplete interactome

Menche, J., Sharma, A., Kitsak, M., Ghiassian, S. D., Vidal, M., Loscalzo, J., & Barabási, A.-L. (2015) · Science

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 1,546

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling

Selenium in Biological SystemsRedox biology and oxidative stress

Cited by 1,280

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 1,238

The biology of nitrogen oxides in the airways

Gaston, B., Drazen, J. M., Loscalzo, J., & Stamler, J. S. (1994) · American Journal of Respiratory and Critical Care Medicine

Nitric Oxide and Endothelin EffectsAsthma and respiratory diseases

Cited by 918

Genetic Misdiagnoses and the Potential for Health Disparities

Manrai, A. K., Funke, B. H., Rehm, H. L., Olesen, M. S., Maron, B. A., Szolovits, P., Margulies, D. M., Loscalzo, J., & Kohane, I. S. (2016) · New England Journal of Medicine

Genomics and Rare DiseasesCardiomyopathy and Myosin Studies

Cited by 808

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

Chan, S. Y., Zhang, Y.-Y., Hemann, C., Mahoney, C. E., Zweier, J. L., & Loscalzo, J. (2009) · Cell Metabolism

MicroRNA in disease regulationMitochondrial Function and Pathology

Cited by 702

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Loscalzo, J. (2001) · Circulation Research

Nitric Oxide and Endothelin EffectsPlatelet Disorders and Treatments

Cited by 612

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 588

Network-based approach to prediction and population-based validation of in silico drug repurposing

Cheng, F., Desai, R. J., Handy, D. E., Wang, R., Schneeweiss, S., Barabási, A.-L., & Loscalzo, J. (2018) · Nature Communications

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 552

Inflammation, Immunity, and Infection in Atherothrombosis

Libby, P., Loscalzo, J., Ridker, P. M., Farkouh, M. E., Hsue, P. Y., Fuster, V., Hasan, A. A., & Amar, S. (2018) · Journal of the American College of Cardiology

Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

Cited by 548

Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice

Rajasekaran, N. S., Connell, P., Christians, E. S., Yan, L.-J., Taylor, R. P., Orosz, A., Zhang, X. Q., Stevenson, T. J., Peshock, R. M., Leopold, J. A., et al. (2007) · Cell

Heat shock proteins researchRedox biology and oxidative stress

Cited by 437

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

Oldham, W. M., Clish, C. B., Yang, Y., & Loscalzo, J. (2015) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 364

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

Splinter, K., Adams, D. R., Bacino, C. A., Bellen, H. J., Bernstein, J. A., Cheatle-Jarvela, A. M., Eng, C. M., Esteves, C., Gahl, W. A., Hamid, R., et al. (2018) · New England Journal of Medicine

Genomics and Rare DiseasesMetabolism and Genetic Disorders

Cited by 359

Target identification among known drugs by deep learning from heterogeneous networks

Zeng, X., Zhu, S., Lu, W., Liu, Z., Huang, J., Zhou, Y., Fang, J., Huang, Y., Guo, H., Li, L., et al. (2020) · Chemical Science

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 357

Nitric Oxide in Vascular Biology

Walford, G., & Loscalzo, J. (2003) · Journal of Thrombosis and Haemostasis

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 302

Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection

Zhao, Y., Jin, J., Hu, Q., Zhou, H.-M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., & Loscalzo, J. (2011) · Cell Metabolism

Advanced Fluorescence Microscopy TechniquesMolecular Sensors and Ion Detection

Cited by 302

Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

Schlotter, F., Halu, A., Goto, S., Blaser, M. C., Body, S. C., Lee, L. H., Higashi, H., DeLaughter, D. M., Hutcheson, J. D., Vyas, P., et al. (2018) · Circulation

Cardiac Valve Diseases and TreatmentsAdvanced Proteomics Techniques and Applications

Cited by 256

High glucose inhibits glucose‐6‐phosphate dehydrogenase, leading to increased oxidative stress and β‐cell apoptosis

Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leopold, J. A., Hu, J., Guo, L., Kulkarni, R. N., Loscalzo, J., & Stanton, R. C. (2010) · The FASEB Journal

Pancreatic function and diabetesRedox biology and oxidative stress

Cited by 226

A genome-wide positioning systems network algorithm for in silico drug repurposing

Cheng, F., Lu, W., Liu, C., Fang, J., Hou, Y., Handy, D. E., Wang, R., Zhao, Y., Yang, Y., Huang, J., et al. (2019) · Nature Communications

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 215

Heterozygous Cellular Glutathione Peroxidase Deficiency in the Mouse: Abnormalities in Vascular and Cardiac Function and Structure

Forgione, M. A., Cap, A., Liao, R., Moldovan, N. I., Eberhardt, R. T., Lim, C. C., Jones, J., Goldschmidt-Clermont, P. J., & Loscalzo, J. (2002) · Circulation

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 200