The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Diurnal Regulation of MTP and Plasma Triglyceride by CLOCK Is Mediated by SHP
Open accessAbstract
Summary We examined the role of clock genes in the diurnal regulation of plasma triglyceride-rich apolipoprotein B-lipoproteins and their biosynthetic chaperone, microsomal triglyceride transfer protein (MTP). Clock mt/mt mice showed sustained hypertriglyceridemia and high MTP expression. CLOCK knockdown activated MTP promoter, and reduced small heterodimer partner (SHP, NROB2). CLOCK up-regulated SHP by binding to its E-box. SHP suppressed MTP expression by binding to the HNF4α/LRH-1 at the MTP promoter. Cyclic expression of MTP after serum shock was abrogated by siCLOCK and siSHP. Plasma triglyceride and MTP showed reduced diurnal variations in Shp −/− mice. Whereas, peaks and nadirs in SHP expression were inversely correlated with those of MTP, these changes were reduced in Clockmt/mt mice. Expression of Shp abrogated hypertriglyceridemia in Clockmt/mt mice. Together, these studies describe a role of Clock/Shp in the diurnal regulation of MTP and plasma triglyceride and indicate that disruptions in circadian regulation might cause hyperlipidemia.
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Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
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Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
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“For example, Clock/Bmal1 enhance expression of Rev-erba and albumin D element-binding protein (DBP) that regulate bile acid and drug metabolisms (Green et al., 2008; Lowrey and Takahashi, 2004; Hussain and Pan, 2009).”
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308
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Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Role of the Gut in Lipid Homeostasis
Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235
Metadata
- Authors
- Pan, X., Zhang, Y., Wang, L., & Hussain, M. M.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 12
- Issue
- 2
- Pages
- 174-186
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2066327741
- Cited by
- 180
- References
- 9
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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