Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Open accessAbstract
Most aspects of energy metabolism display clear variations during day and night. This daily rhythmicity of metabolic functions, including hormone release, is governed by a circadian system that consists of the master clock in the suprachiasmatic nuclei of the hypothalamus (SCN) and many secondary clocks in the brain and peripheral organs. The SCN control peripheral timing via the autonomic and neuroendocrine system, as well as via behavioral outputs. The sleep-wake cycle, the feeding/fasting rhythm and most hormonal rhythms, including that of leptin, ghrelin and glucocorticoids, usually show an opposite phase (relative to the light-dark cycle) in diurnal and nocturnal species. By contrast, the SCN clock is most active at the same astronomical times in these two categories of mammals. Moreover, in both species, pineal melatonin is secreted only at night. In this review we describe the current knowledge on the regulation of glucose and lipid metabolism by central and peripheral clock mechanisms. Most experimental knowledge comes from studies in nocturnal laboratory rodents. Nevertheless, we will also mention some relevant findings in diurnal mammals, including humans. It will become clear that as a consequence of the tight connections between the circadian clock system and energy metabolism, circadian clock impairments (e.g., mutations or knock-out of clock genes) and circadian clock misalignments (such as during shift work and chronic jet-lag) have an adverse effect on energy metabolism, that may trigger or enhancing obese and diabetic symptoms.
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Gimble, J. M., & Floyd, Z. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00090.2009 · Cited by 46 · see citing works
Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., Ptacek, L. J., & Akassoglou, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2757-12.2013 · Cited by 44 · see citing works
Adenosine A3 receptors regulate heart rate, motor activity and body temperature
Yang, J., Wang, Y., García-Rovés, P. M., et al. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02091.x · Cited by 42 · see citing works
Deep, Dark Secrets of Melatonin in Animal Evolution
(2014) · doi:10.1016/j.cell.2014.09.004 · Cited by 36 · see citing works
The circadian rhythm of synthesis and catabolism of cholesterol
Mayer, D. (1976) · Archives of Toxicology · doi:10.1007/bf00340534 · Cited by 35 · see citing works
Daily variations of blood glucose, acid-base state and PCO2 in rats: effect of light exposure
Challet, É., Malan, A., Turek, F. W., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.041 · Cited by 34 · see citing works
Su, Y., van der Spek, R., Foppen, E., Kwakkel, J., Fliers, E., & Kalsbeek, A. (2014) · Chronobiology International · doi:10.3109/07420528.2014.963198 · Cited by 34 · see citing works
Self-citationVerhagen, L. A. W., Pévet, P., Saboureau, M., Sicard, B., Nesme, B., Claustrat, B., Buijs, R. M., & Kalsbeek, A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.10.003 · Cited by 33 · see citing works
Self-citationInvolvement of adrenergic mechanism in hyperglycemia due to SCN stimulation
Fujii, T., Inoue, S., Nagai, K., & Nakagawa, H. (1989) · Hormone and Metabolic Research · doi:10.1055/s-2007-1009309 · Cited by 30 · cited 2× · see citing works
“…branches of autonomic nervous system and their involvement in the hyperglycemia induced in animals whose SCN was electrically stimulated, supported the view that the SCNeautonomic nervous system axis is implicated in the regulation of glucose homeostasis (Fujii et al., 1989; Nagai et al., 1988).”
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Demonstration of a Dawn Phenomenon in Normal Adolescents
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Haraguchi, A., Aoki, N., Ohtsu, T., Ikeda, Y., Tahara, Y., & Shibata, S. (2014) · Chronobiology International · doi:10.3109/07420528.2014.931413 · Cited by 24 · see citing works
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The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity
van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jörgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.012 · Cited by 218 · see citing works
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173 · see citing works
Self-citationModulation of circadian clocks by nutrients and food factors
Oike, H. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1281722 · Cited by 53 · see citing works
Wang, L., McFadden, J. W., Yang, G., Zhu, H., Lian, H., Fu, T., Sun, Y., Gao, T., & Li, M. (2021) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13497 · Cited by 28 · see citing works
- Authors
- Kumar Jha, P., Challet, E., & Kalsbeek, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Kalsbeek, Andries
- ORCID
- Kalsbeek, Andries
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 418
- Pages
- 74-88
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2036157313
- Semantic Scholar
- 4317412548cf3ea76a62ce2f2dc8df5ba140d93f
- Cited by
- 235
- References
- 206
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 22 · 2023: 22 · 2022: 13 · 2021: 36 · 2020: 22 · 2019: 19 · 2018: 17 · 2017: 28 · 2016: 16 · 2015: 5
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- HAL (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
- Funders
- “Neurotime” Erasmus Mundus program
- University of Strasbourg
- University of Amsterdam
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian rhythm, glucose metabolism, lipid metabolism, energy metabolism, suprachiasmatic nucleus, clock genes, nocturnal mammals, diurnal mammals, melatonin, leptin, ghrelin, glucocorticoids, sleep-wake cycle, shift work, jet lag, obesity, diabetes mellitus
- MeSH terms
- Animals, Circadian Rhythm, Glucose, Humans, Hypothalamus, Suprachiasmatic Nucleus, Carbohydrate Metabolism, Lipid Metabolism, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-10.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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