Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Lowrey, Phillip L.; Takahashi, Joseph S.

doi:10.1146/annurev.genom.5.061903.175925

Cited by 976Circadian rhythm and melatoninPlant Molecular Biology ResearchSleep and Work-Related Fatigue

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Open access

Lowrey, Phillip L., Takahashi, Joseph S.·2004·Annual Review of Genomics and Human Genetics

DOI 10.1146/annurev.genom.5.061903.175925PMC PMC3770722

Open this paper in CoChat — free account

Abstract

During the past decade, the molecular mechanisms underlying the mammalian circadian clock have been defined. A core set of circadian clock genes common to most cells throughout the body code for proteins that feed back to regulate not only their own expression, but also that of clock output genes and pathways throughout the genome. The circadian system represents a complex multioscillatory temporal network in which an ensemble of coupled neurons comprising the principal circadian pacemaker in the suprachiasmatic nucleus of the hypothalamus is entrained to the daily light/dark cycle and subsequently transmits synchronizing signals to local circadian oscillators in peripheral tissues. Only recently has the importance of this system to the regulation of such fundamental biological processes as the cell cycle and metabolism become apparent. A convergence of data from microarray studies, quantitative trait locus analysis, and mutagenesis screens demonstrates the pervasiveness of circadian regulation in biological systems. The importance of maintaining the internal temporal homeostasis conferred by the circadian system is revealed by animal models in which mutations in genes coding for core components of the clock result in disease, including cancer and disturbances to the sleep/wake cycle.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev.genom.5.061903.175925

Cites

243 of 243 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The central clock and peripheral oscillators comprise a self-sustaining network of transcriptional-translational feedback loops that drive 24-hour expression patterns of core clock genes.
“At the molecular level, the central clock (in the suprachiasmatic nucleus) and peripheral oscillators throughout the body comprise a self-sustaining network of transcriptional-translational feedback loops that drive 24-hour expression patterns of core clock genes (47).”
From Social jetlag, chronotype, and cardiometabolic risk (2015) · cites this paper as [47]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works
The Sequence of the Human Genome
Venter, J., Adams, M., Myers, E., Li, P. W., Mural, R., Sutton, G., Smith, H., Yandell, M., Evans, C., Holt, R., et al. (2001) · Science · doi:10.1373/clinchem.2014.237016 · Cited by 6,779 · see citing works
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Lander, E. S., & Kruglyak, L. (1995) · Nature Genetics · doi:10.1038/ng1195-241 · Cited by 5,196 · see citing works
Empirical threshold values for quantitative trait mapping.
Churchill, G. A., & Doerge, R. W. (1994) · Genetics · doi:10.1093/genetics/138.3.963 · Cited by 4,950 · see citing works
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works
Self-citation
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Self-citation
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135 · see citing works
A functional analysis of circadian pacemakers in nocturnal rodents
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417856 · Cited by 2,129 · see citing works
Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039 · see citing works
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 1,997 · see citing works
Self-citation
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Transplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853 · see citing works
Suprachiasmatic nucleus : the mind's clock
Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,713 · see citing works
Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
Harmer, S. L., Hogenesch, J. B., Straume, M., Chang, H.-S., Han, B., Zhu, T., Wang, X., Kreps, J. A., & Kay, S. A. (2000) · Science · doi:10.1126/science.290.5499.2110 · Cited by 1,640 · see citing works
A functional analysis of circadian pacemakers in nocturnal rodents: V. Pacemaker structure: A clock for all seasons
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology ? A · doi:10.1007/bf01417860 · Cited by 1,636 · see citing works
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
Self-citation
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.
Welsh, D. K., Logothetis, D., Meister, M., & Reppert, S. (1995) · Neuron · doi:10.1016/0896-6273(95)90214-7 · Cited by 1,535 · see citing works
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works
Self-citation
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works
Handbook of Behavioral Neurobiology
(2001) · Handbook of behavioral neurobiology · doi:10.1007/978-1-4615-1201-1 · Cited by 1,366 · see citing works
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
Dijk, D., & Czeisler, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03526.1995 · Cited by 1,356 · see citing works
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,158 · see citing works
Time zones: a comparative genetics of circadian clocks
Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,143 · see citing works
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142 · see citing works
Permutation Tests for Multiple Loci Affecting a Quantitative Character
Doerge, R. W., & Churchill, G. A. (1996) · Genetics · doi:10.1093/genetics/142.1.285 · Cited by 1,133 · see citing works
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132 · see citing works
Temporal Organization: Reflections of a Darwinian Clock-Watcher
Pittendrigh, C. S. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.000313 · Cited by 1,023 · see citing works
Liver regeneration
Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022 · see citing works
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937 · see citing works
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H. (2003) · Science · doi:10.1126/science.1089287 · Cited by 934 · see citing works
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900 · see citing works
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 900 · see citing works
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works
Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works
Self-citation
Finding genes that underlie complex traits.
Glazier, A. M., Nadeau, J. H., & Aitman, T. J. (2002) · Science · doi:10.1126/science.1076641 · Cited by 855 · see citing works
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works
Orphan Nuclear Receptors: From Gene to Function
Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0378 · Cited by 848 · see citing works
Mapping and analysis of quantitative trait loci in experimental populations
Doerge, R. W. (2002) · Nature Reviews Genetics · doi:10.1038/nrg703 · Cited by 797 · see citing works
A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms
Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792 · see citing works
Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02890-6 · Cited by 788 · see citing works
The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works
Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference
Archer, S. N., Robilliard, D. L., Skene, D. J., Smits, M. G., Williams, A., Arendt, J., & von Schantz, M. (2003) · SLEEP · doi:10.1093/sleep/26.4.413 · Cited by 734 · see citing works
The mPer2 gene encodes a functional component of the mammalian circadian clock
Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works
Circadian Rhythms in Cultured Mammalian Retina
Tosini, G., & Menaker, M. (1996) · Science · doi:10.1126/science.272.5260.419 · Cited by 716 · see citing works
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
Cheng, M. Y., Bullock, C. M., Li, C., Lee, A. G., Bermak, J. C., Belluzzi, J., Weaver, D. R., Leslie, F. M., & Zhou, Q.-Y. (2002) · Nature · doi:10.1038/417405a · Cited by 715 · see citing works
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma
Battey, J., Moulding, C. T., Taub, R. A., Murphy, W., Stewart, T. A., Potter, H., Lenoir, G., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90534-2 · Cited by 714 · see citing works
Health in a 24-h society
Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711 · see citing works
Melanopsin is required for non-image-forming photic responses in blind mice
Panda, S., Provencio, I., Tu, D. C., Pires, S. S., Rollag, M. D., Castrucci, A. M., Pletcher, M. T., Sato, T. K., Wiltshire, T., Andahazy, M., et al. (2003) · Science · doi:10.1126/science.1086179 · Cited by 711 · see citing works
A Mutation of the Circadian System in Golden Hamsters
Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 700 · see citing works
Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works
Self-citation
Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation
Edgar, D. M., Dement, W., & Fuller, C. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01065.1993 · Cited by 685 · see citing works
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681 · see citing works
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
Etchegaray, J.-P., Lee, C., Wade, P. A., & Reppert, S. M. (2003) · Nature · doi:10.1038/nature01314 · Cited by 679 · see citing works
Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue
Antoch, M. P., Song, E.-J., Chang, A., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H., & Takahashi, J. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80246-9 · Cited by 665 · see citing works
Self-citation
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., et al. (2000) · Nature Genetics · doi:10.1038/78146 · Cited by 664 · see citing works
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
Nolan, P. M., Peters, J., Strivens, M. A., Rogers, D. C., Hagan, J. J., Spurr, N. K., Gray, I. C., Vizor, L., Brooker, D., Whitehill, E., et al. (2000) · Nature Genetics · doi:10.1038/78140 · Cited by 653 · see citing works
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646 · see citing works
Independent Photoreceptive Circadian Clocks Throughout Drosophila
Plautz, J. D., Kaneko, M. A. N., Hall, J. C., & Kay, S. A. (1997) · Science · doi:10.1126/science.278.5343.1632 · Cited by 640 · see citing works
A neural circuit for circadian regulation of arousal
Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L. (2001) · Nature Neuroscience · doi:10.1038/89522 · Cited by 632 · see citing works
Principles and Practice of Sleep Medicine
Stafford, R. S. (2001) · JAMA · doi:10.1001/jama.285.8.1074 · Cited by 612 · see citing works
A Statistical Framework for Quantitative Trait Mapping
Sen, Ś., & Churchill, G. A. (2001) · Genetics · doi:10.1093/genetics/159.1.371 · Cited by 611 · see citing works
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
McDonald, M. J., & Rosbash, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00545-1 · Cited by 606 · see citing works
Hypothalamic integration of central and peripheral clocks
Buijs, R. M., & Kalsbeek, A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081582 · Cited by 580 · see citing works
NPAS2: an analog of clock operative in the mammalian forebrain
Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572 · see citing works
Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans
Jones, C. R., Campbell, S. S., Zone, S. E., Cooper, F., DeSano, A., Murphy, P. J., Jones, B., Czajkowski, L., & Ptček, L. J. (1999) · Nature Medicine · doi:10.1038/12502 · Cited by 567 · see citing works
Circadian Systems: Entrainment
Pittendrigh, C. S. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6552-9_7 · Cited by 556 · see citing works
Strange vision: ganglion cells as circadian photoreceptors
Berson, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00130-9 · Cited by 546 · see citing works
Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling
Kramer, A., Yang, F.-C., Snodgrass, P., Li, X., Scammell, T. E., Davis, F. C., & Weitz, C. J. (2001) · Science · doi:10.1126/science.1067716 · Cited by 536 · see citing works
Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms
Takahashi, J. S., DeCoursey, P. J., Bauman, L., & Menaker, M. (1984) · Nature · doi:10.1038/308186a0 · Cited by 528 · see citing works
Self-citation
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., Watanabe, T., Sekimoto, M., Shibui, K., Kim, K., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve070 · Cited by 517 · see citing works
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
Russell, W. L., Kelly, E. M., Hunsicker, P. R., Bangham, J. W., Maddux, S. C., & Phipps, E. L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5818 · Cited by 517 · see citing works
Neuropsychological mechanisms of interval timing behavior
Matell, M. S., & Meck, W. H. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200001)22:1 · Cited by 513 · see citing works
Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei
Liu, C., Weaver, D. R., Strogatz, S. H., & Reppert, S. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80473-0 · Cited by 508 · see citing works
Increased breast cancer risk among women who work predominantly at night
Hansen, J. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00013 · Cited by 503 · see citing works
Restoration of circadian behavioural rhythms by gene transfer in Drosophila
Bargiello, T. A., Jackson, F. R., & Young, M. W. (1984) · Nature · doi:10.1038/312752a0 · Cited by 498 · see citing works
Light acts directly on organs and cells in culture to set the vertebrate circadian clock
Whitmore, D., Foulkes, N. S., & Sassone‐Corsi, P. (2000) · Nature · doi:10.1038/35003589 · Cited by 481 · see citing works
Microarray Analysis of Diurnal and Circadian-Regulated Genes in Arabidopsis
Schaffer, R. J., Landgraf, J., Accerbi, M., Simon, V. A., Larson, M., & Wisman, E. (2001) · The Plant Cell · doi:10.1105/tpc.13.1.113 · Cited by 457 · see citing works
The hypothalamic suprachiasmatic nucleus of rat: Intrinsic anatomy
van den Pol, A. N. (1980) · The Journal of comparative neurology · doi:10.1002/cne.901910410 · Cited by 447 · see citing works
Circadian Regulation of Gene Expression Systems in the Drosophila Head
Claridge‐Chang, A., Wijnen, H., Naef, F., Boothroyd, C. E., Rajewsky, N., & Young, M. W. (2001) · Neuron · doi:10.1016/s0896-6273(01)00515-3 · Cited by 444 · see citing works
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 441 · see citing works
Molecular Bases of Circadian Rhythms
Harmer, S. L., Panda, S., & Kay, S. A. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.215 · Cited by 440 · see citing works
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBPPreprint
Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429 · see citing works
Orphan Nuclear Receptors: From Gene to Function
Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/er.20.5.689 · Cited by 423 · see citing works
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse
Lindblad‐Toh, K., Winchester, E., Daly, M. J., et al. (2000) · Nature Genetics · doi:10.1038/74215 · Cited by 421 · see citing works
Mouse ENU Mutagenesis
Justice, M. J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1955 · Cited by 418 · see citing works
GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei
van Doorninck, J. H., van der Wees, J., Karis, A., Sabel-Goedknegt, E., Coesmans, M., Rutteman, M., Grosveld, F. G., & Zeeuw, C. I. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-j0002.1999 · Cited by 416 · see citing works
Metabolism and the Control of Circadian Rhythms
Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 401 · see citing works
Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
Thresher, R., Vitaterna, M. H., Miyamoto, Y., Kazantsev, A. G., Hsu, D. S., Petit, C. R., Selby, C. P., Dawut, L., Smithies, O., Takahashi, J. S., et al. (1998) · Science · doi:10.1126/science.282.5393.1490 · Cited by 401 · see citing works
Self-citation
P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic drosophila melanogaster
Zehring, W. A., Wheeler, D. A., Reddy, P., Konopka, R. J., Kyriacou, C. P., Rosbash, M., & Hall, J. C. (1984) · Cell · doi:10.1016/0092-8674(84)90015-1 · Cited by 393 · see citing works
Clock controls circadian period in isolated suprachiasmatic nucleus neurons
Herzog, E. D., Takahashi, J. S., & Block, G. D. (1998) · Nature Neuroscience · doi:10.1038/3708 · Cited by 387 · see citing works
Self-citation
N2 Fixation by non-heterocystous cyanobacteria1
Bergman, B., Gallon, J., Rai, A., & Stal, L. J. (2006) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1997.tb00296.x · Cited by 385 · see citing works
Interlocked Feedback Loops Within the Drosophila Circadian Oscillator
Glossop, N. R. J., Lyons, L. C., & Hardin, P. E. (1999) · Science · doi:10.1126/science.286.5440.766 · Cited by 381 · see citing works
Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences
Blackwell, T. K., Huang, J., Ma, A. I., Kretzner, L., Alt, F. W., Eisenman, R. N., & Weintraub, H. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5216 · Cited by 377 · see citing works
Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock
Okamura, H., Miyake, S., Sumi, Y., Yamaguchi, S., Yasui, A., Muijtjens, M., Hoeijmakers, J. H. J., & van der Horst, G. T. J. (1999) · Science · doi:10.1126/science.286.5449.2531 · Cited by 375 · see citing works
Interconnected Feedback Loops in the Neurospora Circadian System
Lee, K., Loros, J., & Dunlap, J. (2000) · Science · doi:10.1126/science.289.5476.107 · Cited by 363 · see citing works
Genome-Wide Expression Analysis inDrosophilaReveals Genes Controlling Circadian Behavior
Ceriani, M. F., Hogenesch, J. B., Yanovsky, M. J., Panda, S., Straume, M., & Kay, S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09305.2002 · Cited by 358 · see citing works
Mammalian Circadian Autoregulatory Loop
Sangoram, A. M., Sáez, L., Antoch, M. P., Gekakis, N., Staknis, D., Whiteley, A. R., Fruechte, E. M., Vitaterna, M. H., Shimomura, K., King, D. P., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80627-3 · Cited by 355 · see citing works
Self-citation
Human Circadian Rhythms in Continuous Darkness: Entrainment by Social Cues
Aschoff, J., Fatranská, M., Giedke, H., Doerr, P., Stamm, D., & Wisser, H. (1971) · Science · doi:10.1126/science.171.3967.213 · Cited by 348 · see citing works
Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms
Field, M. D., Maywood, E. S., O'Brien, J. A., Weaver, D. R., Reppert, S. M., & Hastings, M. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80906-x · Cited by 343 · see citing works
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes
Oishi, K., Miyazaki, K., Kadota, K., Kikuno, R. F., Nagase, T., Atsumi, G.-I., Ohkura, N., Azama, T., Mesaki, M., Yukimasa, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304564200 · Cited by 341 · see citing works
Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells
Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J., & Dunlap, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00765-0 · Cited by 329 · see citing works
N2 Fixation by non-heterocystous cyanobacteria
Bergman, B. (1997) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(96)00028-9 · Cited by 329 · see citing works
Glucose Down-regulates Per1 and Per2mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts
Hirota, T., Okano, T., Kokame, K., Shirotani-Ikejima, H., Miyata, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206233200 · Cited by 317 · see citing works
Stopping Time: The Genetics of Fly and Mouse Circadian Clocks
Allada, R., Emery, P., Takahashi, J. S., & Rosbash, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1091 · Cited by 315 · see citing works
Self-citation
Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains
Schwartz, W., & Zimmerman, P. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03685.1990 · Cited by 315 · see citing works
Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ
Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
Shearman, L. P., Jin, X., Lee, C., Reppert, S. M., & Weaver, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6269-6275.2000 · Cited by 304 · see citing works
The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε
Eide, E. J., Vielhaber, E. L., Hinz, W. A., & Virshup, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111466200 · Cited by 301 · see citing works
The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior
Lopez‐Molina, L., Conquet, F., Dubois‐Dauphin, M., & Schibler, U. (1997) · The EMBO Journal · doi:10.1093/emboj/16.22.6762 · Cited by 300 · see citing works
Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain
Sakamoto, K., Nagase, T., Fukui, H., Horikawa, K., Okada, T., Tanaka, H., Sato, K. Z., Miyake, Y., Ohara, O., Kako, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27039 · Cited by 300 · see citing works
Untitled work
Zheng (1999) · doi:10.1038/22659 · Cited by 293 · see citing works
Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells
Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works
Circadian Dynamics of Cytosolic and Nuclear Ca2+ in Single Suprachiasmatic Nucleus Neurons
Ikeda, M., Sugiyama, T., Wallace, C. S., Gompf, H. S., Yoshioka, T., Miyawaki, A., & Allen, C. N. (2003) · Neuron · doi:10.1016/s0896-6273(03)00164-8 · Cited by 273 · see citing works
Nucleocytoplasmic shuttling and mCRY‐dependent inhibition of ubiquitylation of the mPER2 clock protein
Yagita, K., Tamanini, F., Yasuda, M., Hoeijmakers, J. H. J., van der Horst, G. T. J., & Okamura, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1301 · Cited by 271 · see citing works
Genome-wide Transcriptional Orchestration of Circadian Rhythms inDrosophila
Ueda, H. R., Matsumoto, A., Kawamura, M., Iino, M., Tanimura, T., & Hashimoto, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100765200 · Cited by 264 · see citing works
Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting
Kalsbeek, A., & Buijs, R. M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0577-0 · Cited by 261 · see citing works
Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro
van den Pol, A. N., Finkbeiner, S., & Cornell-Bell, A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02648.1992 · Cited by 252 · see citing works
Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene
Cermakian, N., Monaco, L., Pando, M. P., Dierich, A., & Sassone‐Corsi, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.3967 · Cited by 252 · see citing works
Role of DBP in the Circadian Oscillatory Mechanism
Yamaguchi, S., Mitsui, S., Yan, L., Yagita, K., Miyake, S., & Okamura, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4773-4781.2000 · Cited by 252 · see citing works
Cancer chronotherapy: Principles, applications, and perspectives
Mormont, M., & Lévi, F. (2002) · Cancer · doi:10.1002/cncr.11040 · Cited by 251 · see citing works
Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro
Jagota, A., de la Iglesia, H. O., & Schwartz, W. J. (2000) · Nature Neuroscience · doi:10.1038/73943 · Cited by 246 · see citing works
Extraocular Circadian Phototransduction in Humans
Campbell, S. S., & Murphy, P. (1998) · Science · doi:10.1126/science.279.5349.396 · Cited by 246 · see citing works
Forward and Reverse Genetic Approaches to Behavior in the Mouse
Takahashi, J. S., Pinto, L. H., & Vitaterna, M. H. (1994) · Science · doi:10.1126/science.8209253 · Cited by 242 · see citing works
Self-citation
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock systemPreprint
Kondratov, R. V., Chernov, M. V., Kondratova, A. A., Gorbacheva, V., Gudkov, A. V., & Antoch, M. P. (2003) · Genes & Development · doi:10.1101/gad.1099503 · Cited by 238 · see citing works
Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in MicePreprint
Shimomura, K., Low-Zeddies, S. S., King, D. P., Steeves, T. D. L., Whiteley, A. R., Kushla, J., Zemenides, P. D., Lin, A., Vitaterna, M. H., Churchill, G. A., et al. (2001) · Genome Research · doi:10.1101/gr.171601 · Cited by 236 · see citing works
Self-citation
DNA microarray analyses of circadian timing: the genomic basis of biological time
Duffield, G. E. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01082.x · Cited by 234 · see citing works
Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock
Pennartz, C. M. A., de Jeu, M. T. G., Bos, N. P. A., Schaap, J., & Geurtsen, A. M. S. (2002) · Nature · doi:10.1038/nature728 · Cited by 234 · see citing works
From the Gene to Behavior.
Benzer, S. (1971) · PubMed · doi:10.5281/zenodo.10735825 · Cited by 231 · see citing works
Molecular Components of the Circadian System in Drosophila
Williams, J. A., & Sehgal, A. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.729 · Cited by 211 · see citing works
The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat
Harding, H. P., & Lazar, M. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4791 · Cited by 210 · see citing works
Requirement of Mammalian Timeless for Circadian Rhythmicity
Barnes, J. W., Tischkau, S. A., Barnes, J. A., Mitchell, J. W., Burgoon, P. W., Hickok, J. R., & Gillette, M. U. (2003) · Science · doi:10.1126/science.1086593 · Cited by 207 · see citing works
Assembling a Clock for All Seasons: Are There M and E Oscillators in the Genes?
Daan, S., Albrecht, U., van der Horst, G. T. J., Illnerová, H., Roenneberg, T., Wehr, T. A., & Schwartz, W. J. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001809 · Cited by 204 · see citing works
Influence of the period -dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster
Lin, Y., Han, M., Shimada, B., Wang, L., Gibler, T. M., Amarakone, A., Awad, T. A., Stormo, G. D., Gelder, R. N. V., & Taghert, P. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132269699 · Cited by 190 · see citing works
Suprachiasmatic nucleus: a central autonomic clock
Ueyama, T., Krout, K. E., Nguyen, X. V., Karpitskiy, V. V., Kollert, A., Mettenleiter, T. C., & Loewy, A. D. (1999) · Nature Neuroscience · doi:10.1038/15973 · Cited by 188 · see citing works
Circadian periods of single suprachiasmatic neurons in rats
Honma, S., Shirakawa, T., Katsuno, Y., Namihira, M., & Honma, K. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00464-9 · Cited by 184 · see citing works
A time-less function for mouse Timeless
Gotter, A. L., Manganaro, T. F., Weaver, D. R., Kolakowski, L. F., Possidente, B. P., Sathyanarayanan, S., MacLaughlin, D. T., & Reppert, S. M. (2000) · Nature Neuroscience · doi:10.1038/77653 · Cited by 179 · see citing works
Molecular Analysis of Mammalian Timeless
Zylka, M. J., Shearman, L. P., Levine, J. D., Jin, X., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80628-5 · Cited by 169 · see citing works
Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism
Hastings, M. H., Field, M. D., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-j0001.1999 · Cited by 166 · see citing works
The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit
King, D. P., Vitaterna, M. H., Chang, A., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1997) · Genetics · doi:10.1093/genetics/146.3.1049 · Cited by 162 · see citing works
Self-citation
Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus
Colwell, C. S. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00939.x · Cited by 161 · see citing works
The Use of a Genetic Algorithm for Simultaneous Mapping of Multiple Interacting Quantitative Trait Loci
Carlborg, Ö., Andersson, L., & Kinghorn, B. P. (2000) · Genetics · doi:10.1093/genetics/155.4.2003 · Cited by 157 · see citing works
The 5′ upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation
Yamaguchi, S., Mitsui, S., Miyake, S., Yan, L., Onishi, H., Yagita, K., Suzuki, M., Shibata, S., Kobayashi, M., & Okamura, H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00602-3 · Cited by 157 · see citing works
Circadian rhythm of cellular proliferation in the human rectal mucosa
Buchi, K. N., Moore, J. G., Hrushesky, W. J. M., Sothern, R. B., & Rubin, N. H. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90019-h · Cited by 156 · see citing works
Chromosome cohesion is regulated by a clock gene paralogue TIM-1
Chan, R. C., Chan, A., Jeon, M., Wu, T. F., Pasqualone, D., Rougvie, A. E., & Meyer, B. J. (2003) · Nature · doi:10.1038/nature01697 · Cited by 156 · see citing works
Suprachiasmatic Nucleus Grafts Restore Circadian Behavioral Rhythms of Genetically Arrhythmic Mice
Sujino, M., Masumoto, K., Yamaguchi, S., van der Horst, G. T. J., Okamura, H., & Inouye, S. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00222-7 · Cited by 153 · see citing works
Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2
Camacho, F., Cilio, M., Guo, Y., Virshup, D. M., Patel, K., Khorkova, O., Styren, S. D., Morse, B., Yao, Z., & Keesler, G. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02434-0 · Cited by 153 · see citing works
Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies
Kita, Y., Shiozawa, M., Weihong, J., Majewski, R. R., Besharse, J. C., Greene, A. S., & Jacob, H. J. (2002) · Pharmacogenetics · doi:10.1097/00008571-200201000-00008 · Cited by 152 · see citing works
Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2
Yu, W., Nomura, M., & Ikeda, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6300 · Cited by 149 · see citing works
Familial Advanced Sleep Phase Syndrome
Reid, K. J., Chang, A., Dubocovich, M. L., Turek, F. W., Takahashi, J. S., & Zee, P. C. (2001) · Archives of Neurology · doi:10.1001/archneur.58.7.1089 · Cited by 148 · see citing works
Self-citation
Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior
Low-Zeddies, S. S., & Takahashi, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00294-x · Cited by 147 · see citing works
Self-citation
Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian Photoentrainment
Rollag, M. D., Berson, D. M., & Provencio, I. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003005 · Cited by 147 · see citing works
Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus
Yan, L., & Okamura, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01955.x · Cited by 146 · see citing works
Is the cell division cycle gated by a circadian clock? The case of Chlamydomonas reinhardtii.
Goto, K., & Johnson, C. H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.4.1061 · Cited by 140 · see citing works
Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues
Oishi, K., Fukui, H., & Ishida, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2054 · Cited by 140 · see citing works
Photic and circadian expression of luciferase in mPeriod1 - luc transgenic mice in vivo
Wilsbacher, L. D., Yamazaki, S., Herzog, E. D., Song, E.-J., Radcliffe, L. A., Abe, M., Block, G. D., Spitznagel, E. L., Menaker, M., & Takahashi, J. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012248599 · Cited by 138 · see citing works
Self-citation
Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε
Keesler, G. A., Camacho, F., Guo, Y. X., Virshup, D. M., Mondadori, C., & Yao, Z. (2000) · Neuroreport · doi:10.1097/00001756-200004070-00011 · Cited by 136 · see citing works
GFP fluorescence reports Period 1 circadian gene regulation in the mammalian biological clock
Kuhlman, S. J., Quintero, J. E., & McMahon, D. G. (2000) · Neuroreport · doi:10.1097/00001756-200005150-00024 · Cited by 132 · see citing works
Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts
Grundschober, C., Delaunay, F., Pühlhofer, A., Triqueneaux, G., Laudet, V., Bartfai, T., & Nef, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107499200 · Cited by 127 · see citing works
Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences
Blackwell, T. K., Huang, J., Ma, A., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5216-5224.1993 · Cited by 127 · see citing works
A cyanobacterial circadian timing mechanism.
Ditty, J., Williams, S., & Golden, S. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.142716 · Cited by 122 · see citing works
The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors
Hogenesch, J. B., Gu, Y.-Z., Moran, S. M., Shimomura, K., Radcliffe, L. A., Takahashi, J. S., & Bradfield, C. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-13-j0002.2000 · Cited by 120 · see citing works
Self-citation
A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.
Adelmant, G., Begue, A., Stéhelin, D., & Laudet, V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3553 · Cited by 119 · see citing works
ENU Mutagenesis: Analyzing Gene Function in Mice
Balling, R. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.463 · Cited by 119 · see citing works
Rhythms in human bone marrow and blood cells
Smaaland, R., Sothern, R. B., Lærum, O. D., et al. (2002) · Chronobiology International · doi:10.1081/cbi-120002594 · Cited by 114 · see citing works
Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus
Nakamura, W., Honma, S., Shirakawa, T., & Honma, K.-I. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01684.x · Cited by 113 · see citing works
Temperature compensation and temperature entrainment of the chick pineal cell circadian clock
Barrett, R. K., & Takahashi, J. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05681.1995 · Cited by 111 · see citing works
Self-citation
The genetics of sleep disorders
Taheri, S., & Mignot, E. J.-M. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00103-5 · Cited by 109 · see citing works
Oscillating on Borrowed Time: Diffusible Signals from Immortalized Suprachiasmatic Nucleus Cells Regulate Circadian Rhythmicity in Cultured Fibroblasts
Allen, G. C., Rappe, J., Earnest, D. J., & Cassone, V. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07937.2001 · Cited by 104 · see citing works
Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse
Kapfhamer, D., Valladares, O., Sun, Y., Nolan, P. M., Rux, J. J., Arnold, S. E., Veasey, S. C., & Bućan, M. (2002) · Nature Genetics · doi:10.1038/ng991 · Cited by 102 · see citing works
Two Pedigrees of Familial Advanced Sleep Phase Syndrome in Japan
Satoh, K., Mishima, K., Inoue, Y., Ebisawa, T., & Shimizu, T. (2003) · SLEEP · doi:10.1093/sleep/26.4.416 · Cited by 101 · see citing works
Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees
Wright, K. P., & Czeisler, C. A. (2002) · Science · doi:10.1126/science.1071697 · Cited by 96 · see citing works
Congenic mice: cutting tools for complex immune disorders
Rogner, U. C., & Avner, P. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1031 · Cited by 96 · see citing works
Expression of mCLOCK and Other Circadian Clock‐Relevant Proteins in the Mouse Suprachiasmatic Nuclei
Maywood, E. S., O’Brien, J., & Hastings, M. H. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00971.x · Cited by 91 · see citing works
CIRCADIAN PHASE RELATIONSHIPS OF THYMIDINE-3H UPTAKE, LABELED NUCLEI, GRAIN COUNTS, AND CELL DIVISION RATE IN RAT CORNEAL EPITHELIUM
Scheving, L. E., & Pauly, J. E. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.32.3.677 · Cited by 87 · see citing works
Circadian clock and microarrays: mammalian genome gets rhythm
Delaunay, F., & Laudet, V. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02794-4 · Cited by 87 · see citing works
The frequency Gene Is Required for Temperature-Dependent Regulation of Many Clock-Controlled Genes in Neurospora crassa
Nowrousian, M., Duffield, G. E., Loros, J., et al. (2003) · Genetics · doi:10.1093/genetics/164.3.923 · Cited by 86 · see citing works
Oscillator control of cell division in Euglena: cyclic AMP oscillations mediate the phasing of the cell division cycle by the circadian clock
Carré, I. A., & Edmunds, L. N. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.4.1163 · Cited by 84 · see citing works
Extraocular Light Exposure Does Not Suppress Plasma Melatonin in Humans
Lockley, S. W., Skene, D. J., Thapan, K., English, J., Ribeiro, D., Haimov, I., Hampton, S. M., Middleton, B., von Schantz, M., & Arendt, J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5244 · Cited by 83 · see citing works
Rhythms in Human Gastrointestinal Mucosa and Skin
Bjarnason, G. A., & Jordan, R. C. (2002) · Chronobiology International · doi:10.1081/cbi-120002595 · Cited by 81 · see citing works
A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim
Benna, C., Scannapieco, P., Piccin, A., Sandrelli, F., Zordan, M. A., Rosato, E., Kyriacou, C. P., Valle, G., & Costa, R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00594-7 · Cited by 79 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[39]Chang AM, Reid KJ, Turek FW, Siddique T, Takahashi JS, Zee PC. Genetic characterization of familial advanced sleep phase syndrome. Presented at Eighth meeting of the Society for Research on Biological Rhythms; Jacksonville, FL. 2002. [[Google Scholar](https://scholar.google.com/scholar_lookup?Chang%20AM,%20Reid%20KJ,%20Turek%20FW,%20Siddique%20T,%20Takahashi%20JS,%20Zee%20PC.%20Genetic%20characterization%20of%20familial%20advanced%20sleep%20phase%20syndrome.%20Presented%20at%20Eighth%20meeting%20of%20the%20Society%20for%20Research%20on%20Biological%20Rhythms;%20Jacksonville,%20FL.%202002.)]

Sorted by citations

Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
Self-citation
Major depressive disorder
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Self-citation
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Self-citation
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449 · see citing works
Self-citation
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216 · see citing works
Self-citation
Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works
Self-citation
The Meter of Metabolism
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works
Self-citation
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765 · see citing works
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression
Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726 · see citing works
Self-citation
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707 · see citing works
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works
Timing of food intake predicts weight loss effectiveness
Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639 · see citing works
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells
Gery, S., Komatsu, N., Baldjyan, L., Yu, A., Koo, D., & Koeffler, H. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.038 · Cited by 630 · see citing works
Role of Sleep and Sleep Loss in Hormonal Release and Metabolism
Leproult, R., & Van Cauter, E. (2010) · Endocrine Development · doi:10.1159/000262524 · Cited by 602 · see citing works
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589 · see citing works
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis
Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536 · see citing works
Social jetlag, chronotype, and cardiometabolic risk
Wong, P. M., Hasler, B. P., Kamarck, T. W., Muldoon, M. F., & Manuck, S. B. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2923 · Cited by 444 · see citing works
A clock shock: mouse CLOCK is not required for circadian oscillator function
DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430 · see citing works
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function
Andrews, J. L., Zhang, X., McCarthy, J. J., McDearmon, E. L., Hornberger, T. A., Russell, B., Campbell, K. S., Arbogast, S., Reid, M. B., Walker, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014523107 · Cited by 389 · see citing works
Self-citation
Circadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369 · see citing works
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351 · see citing works
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., & Yanagisawa, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604189103 · Cited by 290 · see citing works
Links between the innate immune system and sleep
Majde, J. A., & Krueger, J. M. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.005 · Cited by 277 · see citing works
Molecular insights into human daily behavior
Brown, S. A., Kunz, D., Dumas, A., Westermark, P. O., Vanselow, K., Tilmann-Wahnschaffe, A., Herzel, H., & Kramer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707772105 · Cited by 270 · see citing works
Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro
Yagita, K., Horie, K., Koinuma, S., Nakamura, W., Yamanaka, I., Urasaki, A., Shigeyoshi, Y., Kawakami, K., Shimada, S., Takeda, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913256107 · Cited by 241 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
Molecular components of the circadian clock in mammals
Takahashi, J. S. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12514 · Cited by 230 · see citing works
Self-citation
Metabolic cycles as an underlying basis of biological oscillations.
Tu, B. P., & McKnight, S. L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1980 · Cited by 229 · see citing works
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works
A clinical approach to circadian rhythm sleep disorders
Barion, A., & Zee, P. C. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.017 · Cited by 214 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215 · see citing works
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211 · see citing works
Hypotheses for mechanisms linking shiftwork and cancer
Fritschi, L., Glass, D. C., Heyworth, J. S., Aronson, K., Girschik, J., Boyle, T., Grundy, A., & Erren, T. C. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.002 · Cited by 201 · see citing works
Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation
Xie, Z., Su, W., Liu, S., Zhao, G., Esser, K., Schroder, E. A., Lefta, M., Stauss, H. M., Guo, Z., & Gong, M. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76881 · Cited by 189 · see citing works
A role of the circadian system and circadian proteins in aging
KONDRATOV, R. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.02.003 · Cited by 149 · see citing works
The cardiomyocyte molecular clock, regulation of Scn5a , and arrhythmia susceptibility
Schroder, E. A., Lefta, M., Zhang, X., Bartos, D. C., Feng, H.-Z., Zhao, Y., Patwardhan, A., Jin, J.-P., Esser, K. A., & Delisle, B. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2012 · Cited by 147 · see citing works
Clinical aspects of human circadian rhythms
Klerman, E. B. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405278353 · Cited by 139 · see citing works
Chronodisruption and cancer
Erren, T. C., Pape, H. G., Reiter, R. J., & Piekarski, C. (2008) · Naturwissenschaften · doi:10.1007/s00114-007-0335-y · Cited by 133 · see citing works
Fragile X-related proteins regulate mammalian circadian behavioral rhythms
Zhang, J., Fang, Z., Jud, C., Vansteensel, M. J., Kaasik, K., Lee, C. C., Albrecht, U., Tamanini, F., Meijer, J. H., Oostra, B. A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.003 · Cited by 131 · see citing works
Dim light at night exaggerates weight gain and inflammation associated with a high-fat diet in male mice
Fonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125 · see citing works
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Depner, C. M., Melanson, E. L., McHill, A. W., & Wright, K. P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714813115 · Cited by 122 · see citing works
Assessment of circadian function in fibroblasts of patients with bipolar disorder
Yang, S., Van Dongen, H. P. A., Wang, K., Berrettini, W., & Bućan, M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.10 · Cited by 113 · see citing works
A latitudinal cline in the Chinook salmon ( Oncorhynchus tshawytscha ) Clock gene: evidence for selection on PolyQ length variants
O'Malley, K. G., & Banks, M. A. (2008) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2008.0524 · Cited by 111 · see citing works
Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
Hsieh, M.-C., Yang, S.-C., Tseng, H.-L., Hwang, L.-L., Chen, C.-T., & Shieh, K.-R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.228 · Cited by 108 · see citing works
Clock polymorphism in Pacific salmon: evidence for variable selection along a latitudinal gradient
O'Malley, K. G., Ford, M. J., & Hard, J. J. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.0762 · Cited by 97 · see citing works
The etiology of delayed sleep phase disorder
Micic, G., Lovato, N., Gradisar, M., Ferguson, S. A., Burgess, H. J., & Lack, L. C. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.06.004 · Cited by 84 · see citing works
Circadian Rhythms, Skeletal Muscle Molecular Clocks, and Exercise
Schroder, E. A., & Esser, K. A. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a58a70 · Cited by 84 · see citing works
Evolution of a Length Polymorphism in the Human PER3 Gene, a Component of the Circadian System
Nadkarni, N. A., Weale, M. E., von Schantz, M., & Thomas, M. G. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405281332 · Cited by 76 · see citing works
Involvement of dopamine signaling in the circadian modulation of interval timing
Bussi, I. L., Levín, G., Golombek, D. A., & Agostino, P. V. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12569 · Cited by 62 · see citing works
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks
Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., Ptacek, L. J., & Akassoglou, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2757-12.2013 · Cited by 44 · see citing works
The yeast metabolic cycle: insights into the life of a eukaryotic cell
Tu, B. P., & McKnight, S. L. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.019 · Cited by 38 · see citing works
Circadian regulation of cellular physiology
Peek, C. B., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M., & Bass, J. (2015) · Methods in Enzymology · doi:10.1016/bs.mie.2014.10.006 · Cited by 35 · see citing works
A metabolomic study of adipose tissue in mice with a disruption of the circadian system
Castro, C., Briggs, W., Paschos, G. K., FitzGerald, G. A., & Griffin, J. L. (2015) · Molecular BioSystems · doi:10.1039/c5mb00032g · Cited by 33 · see citing works
Stress-Induced Changes in the Expression of the Clock Protein PERIOD1 in the Rat Limbic Forebrain and Hypothalamus: Role of Stress Type, Time of Day, and Predictability
Al-Safadi, S., Al-Safadi, A., Branchaud, M., Rutherford, S., Dayanandan, A., Robinson, B., & Amir, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111166 · Cited by 31 · see citing works

Authors: Lowrey, P. L., & Takahashi, J. S.
Affiliations: Northwestern University (US)
ORCID: Takahashi, Joseph S.
Venue: Annual Review of Genomics and Human Genetics
Publisher: Annual Reviews
Published: 2004-09-22
Volume: 5
Issue: 1
Pages: 407-441
ISSN: 1527-8204 (ISSN-L)
1545-293X
DOI: 10.1146/annurev.genom.5.061903.175925
PMC: PMC3770722
OpenAlex: W2123789196
Cited by: 976
References: 243
Citations by year: 2026: 8 · 2025: 30 · 2024: 28 · 2023: 29 · 2022: 29 · 2021: 29 · 2020: 48 · 2019: 27 · 2018: 40 · 2017: 42 · 2016: 35 · 2015: 38 · 2014: 65 · 2013: 53 · 2012: 62
FWCI: 5.61
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Genomics and Human Genetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: mammalian circadian clock, clock genes, suprachiasmatic nucleus, peripheral circadian oscillators, light-dark cycle entrainment, cell cycle regulation, metabolism, cancer, sleep-wake cycle, quantitative trait loci, mutagenesis screen
MeSH terms: Animals, Circadian Rhythm, Humans, Mammals, Sleep, Wakefulness, Genome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks