The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response
Open accessAbstract
SUMMARY SKN-1/Nrf plays multiple essential roles in development and cellular homeostasis. We demonstrate that SKN-1 executes a specific and appropriate transcriptional response to changes in available nutrients, leading to metabolic adaptation. We isolated gain-of-function (gf) alleles of skn-1, affecting a domain of SKN-1 that binds the transcription factor MXL-3 and the mitochondrial outer membrane protein PGAM-5. These skn-1(gf) mutants perceive a state of starvation even in the presence of plentiful food. The aberrant monitoring of cellular nutritional status leads to an altered survival response in which skn-1(gf) mutants transcriptionally activate genes associated with metabolism, adaptation to starvation, aging, and survival. The triggered starvation response is conserved in mice with constitutively activated Nrf and may contribute to the tumorgenicity associated with activating Nrf mutations in mammalian somatic cells. Our findings delineate an evolutionarily conserved metabolic axis of SKN-1/Nrf, further establishing the complexity of this pathway.
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Cited by
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622
Self-citationYun, J., & Finkel, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.011 · Cited by 626
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Metadata
- Authors
- Paek, J., Lo, J. Y., Narasimhan, S. D., Nguyen, T. N., Glover-Cutter, K., Robida-Stubbs, S., Suzuki, T., Yamamoto, M., Blackwell, T. K., & Curran, S. P.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 16
- Issue
- 4
- Pages
- 526-537
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2156322705
- Cited by
- 181
- References
- 9
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Paek, J., Lo, J. Y., Narasimhan, S. D., Nguyen, T. N., Glover-Cutter, K., Robida-Stubbs, S., Suzuki, T., Yamamoto, M., Blackwell, T. K., & Curran, S. P. (2012). Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.09.007
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