Mitohormesis

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

Signal transduction by reactive oxygen species

Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322 · see citing works

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157 · see citing works

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,120 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M. E., Belcher-Timme, C. A., Sancak, Y., Bao, X., Strittmatter, L., Goldberger, O., Bogorad, R., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,926 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

Antioxidants prevent health-promoting effects of physical exercise in humans

Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works

Lysosomal membrane permeabilization in cell death

Boya, P., & Kroemer, G. (2008) · Oncogene · doi:10.1038/onc.2008.310 · Cited by 1,425 · see citing works

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375 · see citing works

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial

(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · see citing works

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047 · see citing works

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Nargund, A. M., Pellegrino, M., Fiorese, C. J., Baker, B. M., & Haynes, C. M. (2012) · Science · doi:10.1126/science.1223560 · Cited by 1,027 · see citing works

A mitochondrial specific stress response in mammalian cells

Zhao, Q., Wang, J., Levichkin, I. V., Stasinopoulos, S., Ryan, M. T., & Hoogenraad, N. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf445 · Cited by 1,026 · see citing works

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works

Inflammasomes and Their Roles in Health and Disease

Lamkanfi, M., & Dixit, V. M. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155745 · Cited by 935 · cited 1× · see citing works

The Human Mitochondrial Transcriptome

Mercer, T. R., Neph, S., Dinger, M. E., Crawford, J., Smith, M. A., Shearwood, A.-M. J., Haugen, E., Bracken, C. P., Rackham, O., Stamatoyannopoulos, J. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.051 · Cited by 905 · see citing works

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M. N., Kastner, D. L., & Siegel, R. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102049 · Cited by 860 · see citing works

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., & Viña, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.142 · Cited by 844 · see citing works

Transcriptional integration of mitochondrial biogenesis

Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798 · see citing works

Defining hormesis

Calabrese, E. J., & Baldwin, L. A. (2002) · Human & Experimental Toxicology · doi:10.1191/0960327102ht217oa · Cited by 752 · see citing works

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Škrtić, M., Sriskanthadevan, S., Jhas, B., Gebbia, M., Wang, X., Wang, Z., Hurren, R., Jitkova, Y., Gronda, M., MacLean, N., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.015 · Cited by 681 · see citing works

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675 · see citing works

Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1 and SKN-1

Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671 · see citing works

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

Yoneda, T., Benedetti, C., Urano, F., Clark, S. G., Harding, H. P., & Ron, D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01275 · Cited by 636 · see citing works

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000556 · Cited by 630 · see citing works

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y. A., Kawasumi, M., Kouyama, K., Doyu, M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101133498 · Cited by 624 · see citing works

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works

ClpP Mediates Activation of a Mitochondrial Unfolded Protein Response in C. elegans

Haynes, C. M., Petrova, K., Benedetti, C., Yang, Y., & Ron, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.07.016 · Cited by 595 · see citing works

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

Lee, S., Hwang, A. B., & Kenyon, C. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.057 · Cited by 495 · see citing works

The matrix peptide exporter HAF-1 signals a mitochondrial unfolded protein response by activating the transcription factor ZC376.7 in C. elegans

Haynes, C. M., Yang, Y., Blais, S., Neubert, T., & Ron, D. (2010) · Molecules and Cells · doi:10.1016/j.molcel.2010.01.015 · Cited by 480 · see citing works

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.013 · Cited by 430 · see citing works

Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review

Franciosi, M., Lucisano, G., Lapice, E., Strippoli, G. F. M., Pellegrini, F., & Nicolucci, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071583 · Cited by 428 · see citing works

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

Owusu-Ansah, E., Song, W., & Perrimon, N. (2013) · Cell · doi:10.1016/j.cell.2013.09.021 · Cited by 395 · see citing works

Signal Transduction by Mitochondrial Oxidants

Finkel, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.271999 · Cited by 390 · see citing works

Genome-wide responses to mitochondrial dysfunction

Epstein, C. B., Waddle, J. A., Hale, W., Davé, V., Thornton, J., Macatee, T. L., Garner, H. R., & Butow, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.297 · Cited by 389 · see citing works

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Al‐Mehdi, A., Pastukh, V. M., Swiger, B. M., Reed, D., Patel, M., Bardwell, G. C., Pastukh, V. V., ALEXEYEV, M. F., & Gillespie, M. N. (2012) · Science Signaling · doi:10.1126/scisignal.2002712 · Cited by 386 · see citing works

Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture

Southam, C. M., & Ehrlich, J. (1943) · Phytopathology · Cited by 370 · see citing works

Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk

Biswas, G., Adebanjo, O. A., Freedman, B. D., Anandatheerthavarada, H. K., Vijayasarathy, C., Zaidi, M., Kotlikoff, M., & Avadhani, N. G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.522 · Cited by 369 · see citing works

Evolutionary conservation of the <i>clk-1</i> -dependent mechanism of longevity: loss of <i>mclk1</i> increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1352905 · Cited by 345 · see citing works

Bacterial social engagements

Henke, J. M., & Bassler, B. L. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.012 · Cited by 341 · see citing works

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328 · see citing works

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

Baker, B. M., Nargund, A. M., Sun, T., & Haynes, C. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002760 · Cited by 326 · see citing works

The Mitochondrial Genotype Can Influence Nuclear Gene Expression in Yeast

Parikh, V. S., Morgan, M. M., Scott, R., Clements, L. S., & Butow, R. A. (1987) · Science · doi:10.1126/science.3027892 · Cited by 324 · see citing works

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

Picard, M. A., Shirihai, O. S., Gentil, B. J., & Burelle, Y. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00584.2012 · Cited by 320 · see citing works

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A., & Shadel, G. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.018 · Cited by 313 · see citing works

Xenohormesis: Sensing the Chemical Cues of Other Species

Howitz, K. T., & Sinclair, D. A. (2008) · Cell · doi:10.1016/j.cell.2008.04.019 · Cited by 301 · see citing works

Humanin: a harbinger of mitochondrial-derived peptides

Lee, C., Yen, K., & Cohen, P. (2013) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2013.01.005 · Cited by 284 · see citing works

Mitochondria-to-Nuclear Signaling Is Regulated by the Subcellular Localization of the Transcription Factors Rtg1p and Rtg3p

Sekito, T., Thornton, J., & Butow, R. A. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.6.2103 · Cited by 251 · see citing works

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Schmeisser, K., Mansfeld, J., Kuhlow, D., Weimer, S., Priebe, S., Heiland, I., Birringer, M., Groth, M., Segref, A., Kanfi, Y., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1352 · Cited by 236 · see citing works

Mechanism of Metabolic Control

Komeili, A., Wedaman, K. P., O'Shea, E. K., & Powers, T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.863 · Cited by 230 · see citing works

Role of the ABC Transporter Mdl1 in Peptide Export from Mitochondria

Young, L. L., Leonhard, K., Tatsuta, T., Trowsdale, J., & Langer, T. (2001) · Science · doi:10.1126/science.1056957 · Cited by 213 · see citing works

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

van Oosten‐Hawle, P., Porter, R. S., & Morimoto, R. I. (2013) · Cell · doi:10.1016/j.cell.2013.05.015 · Cited by 197 · see citing works

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Jeninga, E. H., Schoonjans, K., & Auwerx, J. H. (2010) · Oncogene · doi:10.1038/onc.2010.206 · Cited by 191 · see citing works

Epigenetic silencing mediates mitochondria stress-induced longevity

Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.003 · Cited by 186 · see citing works

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

Chae, S., Ahn, B. Y., Byun, K., Cho, Y. M., Yu, M., Lee, B., Hwang, D., & Park, K. S. (2013) · Science Signaling · doi:10.1126/scisignal.2003266 · Cited by 184 · see citing works

Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response

Paek, J., Lo, J. Y., Narasimhan, S. D., Nguyen, T. N., Glover-Cutter, K. M., Robida-Stubbs, S., Suzuki, T., Yamamoto, M. P., Blackwell, T. K., & Curran, S. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.007 · Cited by 178 · see citing works

Mitochondria to nucleus stress signaling

Biswas, G., Anandatheerthavarada, H. K., Zaidi, M., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211104 · Cited by 173 · see citing works

Coordinate Induction of Energy Gene Expression in Tissues of Mitochondrial Disease Patients

Heddi, A., Stepien, G., Benke, P. J., & Wallace, D. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22968 · Cited by 169 · see citing works

Mitochondrial hormesis links low‐dose arsenite exposure to lifespan extension

Schmeisser, S., Schmeißer, K., Weimer, S., Groth, M., Priebe, S., Fazius, E., Kuhlow, D., Pick, D., Einax, J. W., Guthke, R., et al. (2013) · Aging Cell · doi:10.1111/acel.12076 · Cited by 142 · see citing works

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

Shore, D. E., Carr, C. E., & Ruvkun, G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002792 · Cited by 125 · see citing works

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Lee, M. D., She, Y., Soskis, M. J., Borella, C. P., Gardner, J. R., Hayes, P. A., Dy, B. M., Heaney, M. L., Philips, M. R., Bornmann, W. G., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422269 · Cited by 121 · see citing works

A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation

Richter, U., Lahtinen, T., Marttinen, P., Myöhänen, M., Greco, D., Cannino, G., Jacobs, H. T., Lietzén, N., Nyman, T. A., & Battersby, B. J. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.019 · Cited by 119 · see citing works

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

Jazwinski, S. M., & Kriete, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00139 · Cited by 115 · see citing works

RTG‐dependent mitochondria to nucleus signaling is negatively regulated by the seven WD‐repeat protein Lst8p

Liu, Z., Sekito, T., Epstein, C. B., & Butow, R. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7209 · Cited by 112 · see citing works

Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains

Rothermel, B. A., Thornton, J. L., & Butow, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19801 · Cited by 112 · see citing works

Exploring the therapeutic space around NAD+

Houtkooper, R. H., & Auwerx, J. H. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201207019 · Cited by 109 · see citing works

NAD and ADP ‐ribose metabolism in mitochondria

Dölle, C., Rack, J. G. M., & Ziegler, M. (2013) · FEBS Journal · doi:10.1111/febs.12304 · Cited by 108 · see citing works

Rtg2 Protein Links Metabolism and Genome Stability in Yeast Longevity

Borghouts, C., Benguría, A., Wawryn, J., & Jazwinski, S. M. (2004) · Genetics · doi:10.1534/genetics.166.2.765 · Cited by 101 · see citing works

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Lee, M. D., She, Y., Soskis, M. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22269 · Cited by 95 · see citing works

Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice

Lapointe, J., Stepanyan, Z., Bigras, E., & Hekimi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006569 · Cited by 91 · see citing works

Resistance to type 2 diabetes mellitus: a matter of hormesis?

Kolb, H., & Eizirik, D. L. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.158 · Cited by 86 · see citing works

Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae

Xie, M., & Roy, R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.016 · Cited by 76 · see citing works

Transactivation by Rtg1p, a Basic Helix-Loop-Helix Protein That Functions in Communication between Mitochondria and the Nucleus in Yeast

Rothermel, B. A., Shyjan, A. W., Etheredge, J. L., & Butow, R. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29476 · Cited by 56 · see citing works

Why translation counts for mitochondria – retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation

Battersby, B. J., & Richter, U. (2013) · Journal of Cell Science · doi:10.1242/jcs.131888 · Cited by 38 · see citing works

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

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