A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,542 · see citing works

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,720 · see citing works

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works

Longevity, senescence and the genome

(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403 · see citing works

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057 · see citing works

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,011 · see citing works

The genetics of caloric restriction in Caenorhabditis elegans

Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 967 · see citing works

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891 · see citing works

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7540 · Cited by 862 · see citing works

The ATP synthase is involved in generating mitochondrial cristae morphology

Paumard, P., Vaillier, J., Coulary, B., Schaëffer, J., Soubannier, V., Mueller, D. M., Brèthes, D., di Rago, J., & Velours, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.221 · Cited by 809 · see citing works

Subcellular localization of the yeast proteomePreprint

Kumar, A., Agarwal, S., Heyman, J. A., Matson, S., Heidtman, M. I., Piccirillo, S., Umansky, L., Drawid, A., Jansen, R., Liu, Y., et al. (2002) · Genes & Development · doi:10.1101/gad.970902 · Cited by 737 · see citing works

The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

Honda, Y., & Honda, S. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.11.1385 · Cited by 730 · see citing works

Aging and resistance to oxidative damage in Caenorhabditis elegans.

Larsen, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8905 · Cited by 722 · see citing works

The Rate of Living.

Wright, S., & Pearl, R. (1928) · Journal of the American Statistical Association · doi:10.2307/2276751 · Cited by 676 · see citing works

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675 · see citing works

C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane

Labrousse, A. M., Zappaterra, M. D., Rube, D. A., & van der Bliek, A. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80391-3 · Cited by 670 · see citing works

Regulation of DAF-2 receptor signaling by human insulin and ins-1 , a member of the unusually large and diverse C. elegans insulin gene familyPreprint

Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 639 · see citing works

Longevity, senescence, and the genome

Johnson, T. E. (1992) · Cell · doi:10.1016/0092-8674(92)90463-m · Cited by 575 · see citing works

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

Lakowski, B., & Hekimi, S. (1996) · Science · doi:10.1126/science.272.5264.1010 · Cited by 539 · see citing works

Mitochondrial function in normal and diabetic β-cells

Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519 · see citing works

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

Lee, R., Hench, J., & Ruvkun, G. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00595-4 · Cited by 508 · see citing works

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506 · see citing works

The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.

Okimoto, R., Macfarlane, J. L., Clary, D. O., & Wolstenholme, D. R. (1992) · Genetics · doi:10.1093/genetics/130.3.471 · Cited by 495 · see citing works

Distinct Requirements for Somatic and Germline Expression of a Generally Expressed Caernorhabditis elegans Gene

Kelly, W. G., Xu, S., Montgomery, M. K., & Fire, A. Z. (1997) · Genetics · doi:10.1093/genetics/146.1.227 · Cited by 463 · see citing works

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328 · see citing works

Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

Ewbank, J. J., Barnes, T. M., Lakowski, B., Lussier, M., Bussey, H., & Hekimi, S. (1997) · Science · doi:10.1126/science.275.5302.980 · Cited by 319 · see citing works

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S., & Ishii, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104718200 · Cited by 271 · see citing works

A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

Jonassen, T., Larsen, P. L., & Clarke, C. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.421 · Cited by 197 · see citing works

Mitochondrial Genome Content Is Regulated during Nematode Development

Tsang, W. Y. W., & Lemire, B. D. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6394 · Cited by 187 · see citing works

Mechanisms of life span determination in Caenorhabditis elegans☆

Vanfleteren, J. R., & Braeckman, B. P. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00087-1 · Cited by 181 · see citing works

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

Ahmed, S. C., Alpi, A. F., Hengartner, M. O., & Gartner, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00604-2 · Cited by 160 · see citing works

Mitochondrial Respiratory Chain Deficiency inCaenorhabditis elegans Results in Developmental Arrest and Increased Life Span

Tsang, W. Y., Sayles, L. C., Grad, L. I., Pilgrim, D. B., & Lemire, B. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103999200 · Cited by 148 · see citing works

The Many Shapes of Mitochondrial Membranes

Griparić, L., & van der Bliek, A. M. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.1r008.x · Cited by 145 · see citing works

Assaying metabolic activity in ageing Caenorhabditis elegans

Braeckman, B. P., Houthoofd, K., Vreese, A. D., & Vanfleteren, J. R. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00331-1 · Cited by 125 · see citing works

Genes, mitochondria and aging in filamentous fungi

Osiewacz, H. D. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00010-7 · Cited by 106 · see citing works

Molecular genetics of life span in C. elegans: How much does it teach us?

Hekimi, S., Lakowski, B., Barnes, T. M., & Ewbank, J. J. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(97)01299-7 · Cited by 100 · see citing works

TheC. elegansmaternal-effect geneclk-2is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length

Bénard, C. Y., McCright, B., Zhang, Y., Felkai, S., Lakowski, B., & Hekimi, S. (2001) · Development · doi:10.1242/dev.128.20.4045 · Cited by 68 · see citing works

C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p

Lim, C., Mian, S. I., Dernburg, A. F., & Campisi, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00526-7 · Cited by 51 · see citing works

New clues to old yeast

Jazwinski, S. M. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00244-5 · Cited by 46 · see citing works

Mitochondrial Aminoacyl-?RNA Synthetases

Tzagoloff, A., Gatti, D. L., & Gampel, A. (1990) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60625-x · Cited by 33 · see citing works

Genetics of aging in Drosophila

Rose, M. R. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00042-x · Cited by 29 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

Broken Limits to Life Expectancy

Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works

Genome-wide RNAi screening in Caenorhabditis elegans

Kamath, R. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00050-1 · Cited by 1,562 · see citing works

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

The sites and topology of mitochondrial superoxide production

Brand, M. D. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.003 · Cited by 1,217 · see citing works

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works

Killing the messenger: short RNAs that silence gene expression

Dykxhoorn, D. M., Novina, C., & Sharp, P. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1129 · Cited by 1,290 · see citing works

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works

Trends in oxidative aging theories

Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

Leung, M. C. K., Williams, P. L., Benedetto, A., Au, C., Helmcke, K. J., Aschner, M., & Meyer, J. N. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn121 · Cited by 1,027 · see citing works

The common biology of cancer and ageing

Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works

Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi LibraryPreprint

Rual, J.-F. M., Cerón, J., Koreth, J., Hao, T., Nicot, A.-S., Hirozane-Kishikawa, T., Vandenhaute, J., Orkin, S. H., HILL, D. E., van den Heuvel, S., et al. (2004) · Genome Research · doi:10.1101/gr.2505604 · Cited by 923 · see citing works

siRNAs: applications in functional genomics and potential as therapeutics

Dorsett, Y., & Tuschl, T. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1345 · Cited by 909 · see citing works

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S.-J., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 918 · see citing works

Mitochondrial Signaling

Butow, R. A., & Avadhani, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00179-0 · Cited by 882 · see citing works

A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span

Lehtinen, M. K., Yuan, Z., Boag, P. R., Yang, Y., Villén, J., Becker, E. B. E., DiBacco, S., de la Iglesia, N., Gygi, S. P., Blackwell, T. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.046 · Cited by 842 · see citing works

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500655200 · Cited by 745 · see citing works

Mitochondrial disorders as windows into an ancient organelle

Vafai, S. B., & Mootha, V. K. (2012) · Nature · doi:10.1038/nature11707 · Cited by 733 · see citing works

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 716 · see citing works

SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712 · see citing works

A resource for large-scale RNA-interference-based screens in mammals

Paddison, P. J., Silva, J. M., Conklin, D. S., Schlabach, M., Li, M. Z., Aruleba, S., Balija, V. S., O'Shaughnessy, A., Gnoj, L., Scobie, K., et al. (2004) · Nature Cell Biology · doi:10.1038/nature02370 · Cited by 695 · see citing works

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works

Mitochondrial retrograde signaling

Liu, Z., & Butow, R. A. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090613 · Cited by 680 · see citing works

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

Simmer, F., Moorman, C., van der Linden, A. M., Kuijk, E., van den Berghe, P. V. E., Kamath, R. S., Fraser, A. G., Ahringer, J., & Plasterk, R. H. A. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000012 · Cited by 638 · see citing works

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000556 · Cited by 630 · see citing works

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

Schieke, S. M., Phillips, D., McCoy, J. P., Aponte, A. M., Shen, R.-F., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603536200 · Cited by 623 · see citing works

Mitohormesis

Yun, J., & Finkel, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.011 · Cited by 626 · see citing works

The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Chin, R., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V., Monsalve, G. C., et al. (2014) · Nature · doi:10.1038/nature13264 · Cited by 570 · see citing works

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works

Aging as an event of proteostasis collapse

Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538 · see citing works

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538 · see citing works

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

Hansen, M., Hsu, A., Dillin, A. G., & Kenyon, C. J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010017 · Cited by 533 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16

Oh, S. W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R. J., & Tissenbaum, H. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500749102 · Cited by 531 · see citing works

The Aging Stress Response

Haigis, M. C., & Yankner, B. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.002 · Cited by 525 · see citing works

A systematic RNAi screen for longevity genes in C. elegansPreprint

Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513 · see citing works

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511 · see citing works

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

Lee, S., Hwang, A. B., & Kenyon, C. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.057 · Cited by 495 · see citing works

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

Curran, S. P., & Ruvkun, G. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030056 · Cited by 479 · see citing works

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 449 · see citing works

Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y., & Shadel, G. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.009 · Cited by 422 · see citing works

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works

Puzzles, promises and a cure for ageing

Vijg, J., & Campisi, J. (2008) · Nature · doi:10.1038/nature07216 · Cited by 407 · see citing works

Cell biology of the mitochondrion

van der Bliek, A. M., Sedensky, M. M., & Morgan, P. G. (2017) · Genetics · doi:10.1534/genetics.117.300262 · Cited by 388 · see citing works

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans

Rea, S. L., Ventura, N., & Johnson, T. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050259 · Cited by 383 · see citing works

Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt)

Tian, Y., Garcia, G., Bian, Q., Steffen, K. K., Joe, L., Wolff, S., Meyer, B. J., & Dillin, A. (2016) · Cell · doi:10.1016/j.cell.2016.04.011 · Cited by 370 · see citing works

Two conserved histone demethylases regulate mitochondrial stress-induced longevity

Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.012 · Cited by 363 · see citing works

Axis of ageing: telomeres, p53 and mitochondria

Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works

Mitochondrial dysfunction as a cause of ageing

Trifunović, A., & Larsson, N. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01905.x · Cited by 375 · see citing works

The role of mitochondria in aging

Jang, J. Y., Blum, A., Liu, J., & Finkel, T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120842 · Cited by 358 · see citing works

Signaling the mitochondrial unfolded protein response

Pellegrino, M. W., Nargund, A. M., & Haynes, C. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.019 · Cited by 359 · see citing works

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works

Evolutionary conservation of the <i>clk-1</i> -dependent mechanism of longevity: loss of <i>mclk1</i> increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1352905 · Cited by 345 · see citing works

Transcriptional profiling of aging in human muscle reveals a common aging signature

Zahn, J. M., Sonu, R., Vogel, H., Crane, E., Mazan-Mamczarz, K., Rabkin, R., Davis, R. W., Becker, K. G., Owen, A. B., & Kim, S. K. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020115 · Cited by 351 · see citing works

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345 · see citing works

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Jovaisaite, V., Mouchiroud, L., & Auwerx, J. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.090738 · Cited by 335 · see citing works

Lifespan extension in Caenorhabditis elegans by complete removal of food

Kaeberlein, T. L., Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Fields, S., Kennedy, B. K., & Kaeberlein, M. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00238.x · Cited by 336 · see citing works

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111212 · Cited by 334 · see citing works

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

Baker, B. M., Nargund, A. M., Sun, T., & Haynes, C. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002760 · Cited by 326 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Hypoxia and brain aging: Neurodegeneration or neuroprotection?

Burtscher, J., Mallet, R. T., Burtscher, M., & Millet, G. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101343 · Cited by 346 · see citing works

Alpha-Ketoglutarate: Physiological Functions and Applications

Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y., & Li, D. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.078 · Cited by 324 · see citing works

Caenorhabditis elegans pathways that surveil and defend mitochondria

Liu, Y., Samuel, B. S., Breen, P. C., & Ruvkun, G. (2014) · Nature · doi:10.1038/nature13204 · Cited by 309 · see citing works

The insulin paradox: aging, proteotoxicity and neurodegeneration

Cohen, E., & Dillin, A. G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2474 · Cited by 303 · see citing works

Systematic genome-wide screens of gene function

Carpenter, A. E., & Sabatini, D. M. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1248 · Cited by 296 · see citing works

MicroRNAs Both Promote and Antagonize Longevity in C. elegans

de Lencastre, A., Pincus, Z., Zhou, K. I., Kato, M., Lee, S. S., & Slack, F. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.015 · Cited by 291 · see citing works

The role of mitochondria in stem cell fate and aging

Zhang, H., Menzies, K. J., & Auwerx, J. H. (2018) · Development · doi:10.1242/dev.143420 · Cited by 285 · see citing works

Improving the efficiency of RNA interference in mammals

Mittal, V. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1323 · Cited by 284 · see citing works

Calorie Restriction: Is AMPK a Key Sensor and Effector

Cantó, C., & Auwerx, J. (2011) · Physiology · doi:10.1152/physiol.00010.2011 · Cited by 282 · see citing works

Age-related changes of nuclear architecture in Caenorhabditis elegans

Haithcock, E., Dayani, Y., Neufeld, E., Zahand, A. J., Feinstein, N., Mattout, A., Gruenbaum, Y., & Liu, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506955102 · Cited by 279 · see citing works

Replicative Aging in Yeast: The Means to the End

Steinkraus, K. A., Kaeberlein, M. R., & Kennedy, B. K. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123509 · Cited by 279 · see citing works

Glyoxalase‐1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

Morcos, M., Du, X., Pfisterer, F., Hutter, H., Sayed, A. A. R., Thornalley, P. J., Ahmed, N., Baynes, J., Thorpe, S. R., Kukudov, G., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00371.x · Cited by 276 · see citing works

Mitochondrial energy metabolism and ageing

Bratic, I., & Trifunović, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.004 · Cited by 268 · see citing works

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf‐1 ‐dependent mechanism in Caenorhabditis elegans

Steinkraus, K. A., Smith, E. D., Davis, C., Carr, D. T., Pendergrass, W. R., Sutphin, G. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00385.x · Cited by 265 · see citing works

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

Yen, W.-L., & Klionsky, D. J. (2008) · Physiology · doi:10.1152/physiol.00013.2008 · Cited by 264 · see citing works

Lipid and Carbohydrate Metabolism in Caenorhabditis elegans

Watts, J. L., & Ristow, M. (2017) · Genetics · doi:10.1534/genetics.117.300106 · Cited by 263 · see citing works

The H3K27 demethylase UTX‐1 regulates <i>C. elegans</i> lifespan in a germline‐independent, insulin‐dependent manner

Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works

The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling

Shaw, W. M., Luo, S., Landis, J. N., Ashraf, J. M., & Murphy, C. T. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.058 · Cited by 260 · see citing works

Curcumin-mediated lifespan extension in Caenorhabditis elegans

Liao, V. H., Yu, C., Chu, Y.-J., Li, W.-H., Hsieh, Y., & Wang, T.-T. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.07.008 · Cited by 259 · see citing works

Environmental RNA interference

Whangbo, J., & Hunter, C. P. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.03.007 · Cited by 257 · see citing works

Mitochondrial NADPH, transhydrogenase and disease

Rydström, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.010 · Cited by 256 · see citing works

Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

Pierce, S. B., Chisholm, K. M., Lynch, E. D., Lee, M. K., Walsh, T., Opitz, J. M., Li, W., Klevit, R. E., & King, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103471108 · Cited by 255 · see citing works

Targeting T cell metabolism for therapy

O’Sullivan, D., & Pearce, E. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.004 · Cited by 251 · see citing works

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Kelmer Sacramento, E., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209596 · Cited by 236 · see citing works

Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00571.x · Cited by 251 · see citing works

Mitochondrial dysfunction and longevity in animals: Untangling the knot

Wang, Y., & Hekimi, S. (2015) · Science · doi:10.1126/science.aac4357 · Cited by 248 · see citing works

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

Liberati, N. T., Fitzgerald, K. A., Kim, D. H., Feinbaum, R. L., Golenbock, D. T., & Ausubel, F. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308625101 · Cited by 248 · see citing works

A brief history of RNAi: the silence of the genes

Sen, G. L., & Blau, H. M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6014rev · Cited by 246 · see citing works

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

McCormick, M. A., Delaney, J. R., Tsuchiya, M., Tsuchiyama, S. K., Shemorry, A., Sim, S., Chou, A., Ahmed, U., Carr, D. T., Murakami, C. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.008 · Cited by 246 · see citing works

Spotlight on Nematode Mitochondria in RNAi Mega-Screen

Melov, S. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.47.pe18 · Cited by 5 · see citing works

Mitochondrial Phosphine Toxicity and the Physiology and Genetics of Longevity in Caenorhabditis elegans

Zuryn, S. (2007) · The University of Queensland · doi:10.14264/155666

Mitochondrial dysfunction and reactive oxygen species metabolism in the aging process of «Caenorhabditis elegans»

Yang, W. (2010) · Library and Archives Canada (Government of Canada)

Identification ofCaenorhabditis elegansGenes Regulating Longevity Using Enhanced RNAi-sensitive StrainsPreprint

Samuelson, A. V., Klimczak, R. R., Thompson, D. B., Carr, C. E., & Ruvkun, G. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.068 · Cited by 34 · see citing works

Mitochondrial respiration and reactive oxygen species in C. elegans

Sedensky, M. M., & Morgan, P. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.056 · Cited by 40 · see citing works