The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Open accessAbstract
Summary The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in blood glucose levels during fasting alters the structural organization of this blood-hypothalamus barrier, resulting in the improved access of metabolic substrates to the arcuate nucleus. These changes are mimicked by 2-deoxyglucose-induced glucoprivation and reversed by raising blood glucose levels after fasting. Furthermore, we show that VEGF-A expression in tanycytes modulates these barrier properties. The neutralization of VEGF signaling blocks fasting-induced barrier remodeling and significantly impairs the physiological response to refeeding. These results implicate glucose in the control of blood-hypothalamus exchanges through a VEGF-dependent mechanism, and demonstrate a hitherto unappreciated role for tanycytes and the permeable microvessels associated with them in the adaptive metabolic response to fasting.
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Cites
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Self-citationLeptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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VEGF is required for growth and survival in neonatal mice
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Cited by
A molecular census of arcuate hypothalamus and median eminence cell types
Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4495 · Cited by 817
Hypothalamic inflammation in obesity and metabolic disease
Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour
Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403
Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.
Schneeberger, M., Gomis, R., & Claret, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0398 · Cited by 301
Langlet, F., Mullier, A., Bouret, S. G., Prevot, V., & Dehouck, B. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23355 · Cited by 295
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Metadata
- Authors
- Langlet, F., Levin, B. E., Luquet, S., Mazzone, M., Messina, A., Dunn-Meynell, A. A., Balland, E., Lacombe, A., Mazur, D., Carmeliet, P., Bouret, S. G., Prevot, V., & Dehouck, B.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 17
- Issue
- 4
- Pages
- 607-617
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2031632319
- Cited by
- 388
- References
- 43
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Langlet, F., Levin, B. E., Luquet, S., Mazzone, M., Messina, A., Dunn-Meynell, A. A., Balland, E., Lacombe, A., Mazur, D., Carmeliet, P., Bouret, S. G., Prevot, V., & Dehouck, B. (2013). Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.03.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
