Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

Elias, Carol F; Aschkenasi, Carl; Lee, Charlotte; Kelly, Joseph; Ahima, Rexford S; Bjorbæk, Christian; Flier, Jeffrey S; Saper, Clifford B; Elmquist, Joel K

doi:10.1016/s0896-6273(01)80035-0

Cited by 924Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

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Elias, Carol F, Aschkenasi, Carl, Lee, Charlotte, Kelly, Joseph, Ahima, Rexford S, Bjorbæk, Christian, Flier, Jeffrey S, Saper, Clifford B +1 more·1999·Neuron

DOI 10.1016/s0896-6273(01)80035-0

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Abstract

Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis.

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Leptin activates POMC/CART neurons, which induces hunger and inhibits NPY/AgRP neurons, which induces satiety.
“Leptin activates POMC/CART neurons, which induces hunger and inhibits NPY/AgRP neurons,77,78 which induces satiety.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [77]

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Authors: Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Elmquist, Joel K
ORCID: Elias, Carol F
Lee, Charlotte
Ahima, Rexford S
Flier, Jeffrey S
Saper, Clifford B
Elmquist, Joel K
Venue: Neuron
Publisher: Elsevier BV
Published: 1999-08
Volume: 23
Issue: 4
Pages: 775-786
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)80035-0
OpenAlex: W2012496594
Cited by: 924
References: 79
Citations by year: 2026: 9 · 2025: 12 · 2024: 17 · 2023: 13 · 2022: 25 · 2021: 30 · 2020: 32 · 2019: 38 · 2018: 49 · 2017: 45 · 2016: 32 · 2015: 41 · 2014: 40 · 2013: 47 · 2012: 33
FWCI: 11.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5099 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r29mh056537-01a1)
National Institute of Mental Health (MH-56537, MH44694, R01MH044694)
National Institute of Neurological Disorders and Stroke (NS 33987, R01NS033987)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, neuropeptide Y, proopiomelanocortin, lateral hypothalamus, arcuate nucleus, hypothalamic neurons, retrograde tracing, SOCS3, Fos expression, feeding behavior, body weight homeostasis, neuropeptide signaling
MeSH terms: Suppressor of Cytokine Signaling 3 Protein, Animals, Arcuate Nucleus of Hypothalamus, Body Weight, Cell Count, Eating, Homeostasis, Hypothalamic Area, Lateral, Immunohistochemistry, Male, Neural Pathways, Neurons, Neuropeptide Y, Pro-Opiomelanocortin, Proteins, Repressor Proteins, RNA, Messenger, Transcription Factors, Protein Biosynthesis, Signal Transduction, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, In Situ Hybridization, Leptin, Suppressor of Cytokine Signaling Proteins, Rats

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Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

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