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Cited by 301Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroscience of respiration and sleep

Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.

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Schneeberger, Marc, Gomis, Ramon, Claret, Marc·2014·Journal of Endocrinology
DOI 10.1530/joe-13-0398
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Abstract

Alterations in adequate energy balance maintenance result in serious metabolic disturbances such as obesity. In mammals, this complex process is orchestrated by multiple and distributed neuronal circuits. Hypothalamic and brainstem neuronal circuits are critically involved in the sensing of circulating and local factors conveying information about the energy status of the organism. The integration of these signals culminates in the generation of specific and coordinated physiological responses aimed at regulating energy balance through the modulation of appetite and energy expenditure. In this article, we review current knowledge on the homeostatic regulation of energy balance, emphasizing recent advances in mouse genetics, electrophysiology, and optogenetic techniques that have greatly contributed to improving our understanding of this central process.

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  • Energy expenditure in mice is predominantly regulated by the hypothalamus, centrally, and largely by thermogenic brown adipose tissue (BAT), peripherally.

    “Energy expenditure in mice is predominantly regulated by the hypothalamus, centrally, and largely by thermogenic brown adipose tissue (BAT), peripherally (Varela and Horvath, 2012; Harms and Seale, 2013; Schneeberger et al., 2014).”

    From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Schneeberger et al., 2014

    The ARC neuronal circuits section reports that hypothalamic neurons increase BAT thermogenic function and affect energy expenditure in mice. But the paper does not establish that the hypothalamus is the predominant central regulator or that BAT accounts for most peripheral energy expenditure; its Concluding remarks describe regulation by multiple circuits, including the brainstem. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Authors
Schneeberger, M., Gomis, R., & Claret, M.
Affiliations
  • Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
  • Universitat de Barcelona (ES)
ORCID
Venue
Journal of Endocrinology
Publisher
Bioscientifica
Published
2014-02
Volume
220
Issue
2
Pages
T25-T46
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
DOI
10.1530/joe-13-0398
OpenAlex
W2114799625
Cited by
301
References
26
Citations by year
2026: 24 · 2025: 14 · 2024: 22 · 2023: 17 · 2022: 22 · 2021: 23 · 2020: 31 · 2019: 20 · 2018: 29 · 2017: 23 · 2016: 36 · 2015: 26 · 2014: 14
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • European Foundation for the Study of Diabetes
  • Ministerio de Ciencia e Innovación
  • Universitat de Barcelona
  • Instituto de Salud Carlos III
  • European Regional Development Fund
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
energy balance, hypothalamus, brainstem, neural circuits, homeostatic regulation, obesity, appetite, energy expenditure, energy sensing, mouse genetics, optogenetics, electrophysiology
MeSH terms
Animals, Appetite Regulation, Brain Stem, Energy Metabolism, Homeostasis, Hormones, Humans, Hypothalamus, Neural Pathways, Mice

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