The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins
Open accessAbstract
SUMMARY Numerous cytosolic and nuclear proteins involved in metabolism, DNA maintenance, protein translation, or iron homeostasis depend on iron-sulfur (Fe/S) cofactors, yet their assembly is poorly defined. Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery. CIA1 associates with either CIA2A or CIA2B and the CIA targeting factor MMS19. The CIA2B-CIA1-MMS19 complex binds to and facilitates assembly of most cytosolic-nuclear Fe/S proteins. In contrast, CIA2A specifically matures iron regulatory protein (IRP) 1 which is critical for cellular iron homeostasis. Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks a Fe/S cluster. In summary, CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly, and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization.
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Cites
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“The mitochondrial iron-sulfur cluster (ISC) assembly machinery was inherited from bacteria (Johnson et al., 2005) and is required for the maturation of both mitochondrial and extramitochondrial Fe/S proteins.”
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Control of iron homeostasis by an iron-regulated ubiquitin ligase
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Self-citationSheftel, A. D., Stehling, O., Pierik, A. J., Elsässer, H.-P., Mühlenhoff, U., Webert, H., Hobler, A., Hannemann, F., Bernhardt, R., & Lill, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004250107 · Cited by 406
Self-citationRole of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation
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A Red carpet for iron metabolism
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Mitochondria and Iron: current questions
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Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
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Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart
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Metadata
- Authors
- Stehling, O., Mascarenhas, J., Vashisht, A. A., Sheftel, A. D., Niggemeyer, B., Rösser, R., Pierik, A. J., Wohlschlegel, J. A., & Lill, R.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 18
- Issue
- 2
- Pages
- 187-198
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1976725682
- Cited by
- 170
- References
- 5
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stehling, O., Mascarenhas, J., Vashisht, A. A., Sheftel, A. D., Niggemeyer, B., Rösser, R., Pierik, A. J., Wohlschlegel, J. A., & Lill, R. (2013). Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.06.015
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