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DNA Damage Response and Metabolic Disease
Open accessAbstract
Accumulation of DNA damage has been linked to the process of aging and to the onset of age-related diseases including diabetes. Studies on progeroid syndromes have suggested that the DNA damage response is involved in regulation of metabolic homeostasis. DNA damage could impair metabolic organ functions by causing cell death or senescence. DNA damage also could induce tissue inflammation that disturbs the homeostasis of systemic metabolism. Various roles of molecules related to DNA repair in cellular metabolism are being uncovered, and such molecules could also have an impact on systemic metabolism. This review explores mechanisms by which the DNA damage response could contribute to metabolic dysfunction.
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Metadata
- Authors
- Shimizu, I., Yoshida, Y., Suda, M., & Minamino, T.
- Affiliations
- Niigata University (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Minamino, Tohru
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 20
- Issue
- 6
- Pages
- 967-977
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2048777894
- Cited by
- 286
- References
- 138
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 36 · 2023: 29 · 2022: 32 · 2021: 24 · 2020: 25 · 2019: 29 · 2018: 25 · 2017: 12 · 2016: 18 · 2015: 7
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Diabetes Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Medical Research Foundation
- Takeda Science Foundation
- Ono Medical Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- DNA damage response, metabolic disorders, aging, age-related diseases, diabetes mellitus, progeroid syndromes, metabolic homeostasis, cellular senescence, cell death, tissue inflammation, DNA repair, systemic metabolism
- MeSH terms
- Animals, DNA Damage, DNA Repair, Humans, Metabolic Diseases
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