Cited by 286DNA Repair MechanismsGenetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

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DNA Damage Response and Metabolic Disease

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Shimizu, Ippei, Yoshida, Yohko, Suda, Masayoshi, Minamino, Tohru·2014·Cell Metabolism

DOI 10.1016/j.cmet.2014.10.008

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Abstract

Accumulation of DNA damage has been linked to the process of aging and to the onset of age-related diseases including diabetes. Studies on progeroid syndromes have suggested that the DNA damage response is involved in regulation of metabolic homeostasis. DNA damage could impair metabolic organ functions by causing cell death or senescence. DNA damage also could induce tissue inflammation that disturbs the homeostasis of systemic metabolism. Various roles of molecules related to DNA repair in cellular metabolism are being uncovered, and such molecules could also have an impact on systemic metabolism. This review explores mechanisms by which the DNA damage response could contribute to metabolic dysfunction.

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Authors: Shimizu, I., Yoshida, Y., Suda, M., & Minamino, T.
Affiliations: Niigata University (JP)
Japan Science and Technology Agency (JP)
Corresponding author: Minamino, Tohru
ORCID: Shimizu, Ippei
Yoshida, Yohko
Suda, Masayoshi
Minamino, Tohru
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2014-12
Volume: 20
Issue: 6
Pages: 967-977
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2014.10.008
OpenAlex: W2048777894
Cited by: 286
References: 138
Citations by year: 2026: 15 · 2025: 33 · 2024: 36 · 2023: 29 · 2022: 32 · 2021: 24 · 2020: 25 · 2019: 29 · 2018: 25 · 2017: 12 · 2016: 18 · 2015: 7
FWCI: 1.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 478 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Diabetes Foundation
Ministry of Education, Culture, Sports, Science and Technology
Takeda Medical Research Foundation
Takeda Science Foundation
Ono Medical Research Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: DNA damage response, metabolic disorders, aging, age-related diseases, diabetes mellitus, progeroid syndromes, metabolic homeostasis, cellular senescence, cell death, tissue inflammation, DNA repair, systemic metabolism
MeSH terms: Animals, DNA Damage, DNA Repair, Humans, Metabolic Diseases

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