DNA Damage Response and Metabolic Disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

The intestinal microbiota fuelling metabolic inflammation

Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0198-4 · Cited by 1,089

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

Chaix, A., Lin, T. C., Le, H. D., Chang, M. W., & Panda, S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.004 · Cited by 687

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 425

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Suda, M., Shimizu, I., Katsuumi, G., Yoshida, Y., Hayashi, Y., Ikegami, R., Matsumoto, N., Yoshida, Y., Mikawa, R., Katayama, A., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00151-2 · Cited by 290

Making sense of the ageing methylome

Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00477-6 · Cited by 274

STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Guo, Q., Chen, X., Chen, J., Zheng, G., Xie, C., Wu, H., Miao, Z., Lin, Y., Wang, X., Gao, W., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03341-9 · Cited by 261

A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis

Zhou, D., Jiang, Y. W., Zhong, X. Y., Cox, N. J., Liu, C., & Gamazon, E. R. (2020) · Nature Genetics · doi:10.1038/s41588-020-0706-2 · Cited by 263

Exercise and bone health across the lifespan

Santos, L., Elliott-Sale, K. J., & Sale, C. (2017) · Biogerontology · doi:10.1007/s10522-017-9732-6 · Cited by 274

Obesity, DNA Damage, and Development of Obesity-Related Diseases

Włodarczyk, M., & Nowicka, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051146 · Cited by 257

Vascular senescence in cardiovascular and metabolic diseases

Katsuumi, G., Shimizu, I., Yoshida, Y., & Minamino, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00018 · Cited by 196

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Li, Q., Hagberg, C. E., Silva Cascales, H., Lang, S., Hyvönen, M. T., Salehzadeh, F., Chen, P., Alexandersson, I., Terezaki, E., Harms, M. J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01501-8 · Cited by 178

Cellular senescence in cardiac diseases

Shimizu, I., & Minamino, T. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.05.002 · Cited by 171

Epigenome Maintenance in Response to DNA Damage

Dabin, J., Fortuny, A., & Polo, S. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.006 · Cited by 161

Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Onyango, A. N. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4321714 · Cited by 168

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response

Yue, X., Bai, C., Xie, D., Ma, T., & Zhou, P. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.607428 · Cited by 170

Cell Senescence, DNA Damage, and Metabolism

Shmulevich, R., & Krizhanovsky, V. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8043 · Cited by 157

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases

Pham, P. T., Fukuda, D., Nishimoto, S., Kim‐Kaneyama, J., Lei, X., Takahashi, Y., Sato, T., Tanaka, K., Suto, K., Kawabata, Y., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab249 · Cited by 152

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

Pateras, I. S., Havaki, S., Nikitopoulou, X., Vougas, K. N., Townsend, P. A., Panayiotidis, M. I., Georgakilas, A. G., & Gorgoulis, V. G. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.011 · Cited by 147

Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease

Li, Z., Polhemus, D. J., & Lefer, D. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311134 · Cited by 142

Impact of Age on Human Adipose Stem Cells for Bone Tissue Engineering

Dufrane, D. (2017) · Cell Transplantation · doi:10.1177/0963689717721203 · Cited by 141

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.038 · Cited by 130

Age at natural menopause and risk of type 2 diabetes: a prospective cohort study

Muka, T., Asllanaj, E., Avazverdi, N., Jaspers, L., Stringa, N., Milić, J., Ligthart, S., Ikram, M. A., Laven, J. S. E., Kavousi, M., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4346-8 · Cited by 130

The Role of Sirt6 in Obesity and Diabetes

Kuang, J., Chen, L., Tang, Q., Zhang, J., Li, Y., & He, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00135 · Cited by 122

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Ke, Y., Wang, C., Zhang, J., Zhong, X., Wang, R., Zeng, X., & Ba, X. (2019) · Cells · doi:10.3390/cells8091047 · Cited by 124

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 119

LncRNA Meg3 protects endothelial function by regulating the DNA damage response

Ali, M. S. S. H., Cheng, X., Moran, M., Haemmig, S., Naldrett, M. J., Alvarez, S., Feinberg, M. W., & Sun, X. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1190 · Cited by 113

Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms

Ulrich, C. M., Himbert, C., Holowatyj, A. N., & Hursting, S. D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0053-2 · Cited by 111

Age‐associated de‐repression of retrotransposons in the Drosophila fat body, its potential cause and consequence

Chen, H., Zheng, X., Xiao, D., & Zheng, Y. (2016) · Aging Cell · doi:10.1111/acel.12465 · Cited by 107

Interplay between Immune Checkpoint Proteins and Cellular Metabolism

Lim, S., Phillips, J. B., da Silva, L. M., Zhou, M., Fodstad, Ø., Owen, L. B., & Tan, M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1647 · Cited by 107

Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys

Mitchell, E. L., Davis, A., Brass, K., Dendinger, M. D., Barner, R., Gharaibeh, R. Z., Fodor, A. A., & Kavanagh, K. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0725-y · Cited by 109

Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins

Campos, A., & Clemente‐Blanco, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020446 · Cited by 114

Impact of obesity and overweight on DNA stability: Few facts and many hypotheses

Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98

Purine-Metabolising Enzymes and Apoptosis in Cancer

Camici, M., Garcia‐Gil, M., Pesi, R., Allegrini, S., & Tozzi, M. G. (2019) · Cancers · doi:10.3390/cancers11091354 · Cited by 86

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Milanese, C., Bombardieri, C. R., Sepe, S., Barnhoorn, S., Payán‐Gómez, C., Caruso, D., Audano, M., Pedretti, S., Vermeij, W. P., Brandt, R. M. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12640-5 · Cited by 82

Histone demethylase UTX is a therapeutic target for diabetic kidney disease

Chen, H., Huang, Y., Zhu, X., Liu, C., Yuan, Y., Su, H., Zhang, C., Liu, C., Xiong, M., Qu, Y., et al. (2018) · The Journal of Physiology · doi:10.1113/jp277367 · Cited by 78

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway

Tong, R., Wu, X., Liu, Y., Liu, Y., Zhou, J., Jiang, X., Zhang, L., He, X., & Ma, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2543504 · Cited by 76

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

Qian, M., Liu, Z., Peng, L., Tang, X., Meng, F., Ao, Y., Zhou, M., Wang, M., Cao, X., Qin, B., et al. (2018) · eLife · doi:10.7554/elife.34836 · Cited by 77

Noncoding RNA activated by DNA damage (NORAD): Biologic function and mechanisms in human cancers

Yang, Z., Zhao, Y., Lin, G., Zhou, X., Jiang, X., & Zhao, H. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.11.025 · Cited by 74

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Lahiguera, Á., Hyroššová, P., Figueras, A., Garzón, D., Moreno‐Justicia, R., Soto‐Cerrato, V., McNeish, I. A., Serra, V., Lázaro, C., Barretina-Ginesta, M.-P., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911217 · Cited by 77

Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease

Buj, R., & Aird, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00177 · Cited by 76

Compromised DNA repair is responsible for diabetes‐associated fibrosis

Kumar, V., Agrawal, R., Pandey, A., Kopf, S., Höffgen, M., Kaymak, S., Bandapalli, O. R., Gorbunova, V. A., Seluanov, A., Mall, M. A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103477 · Cited by 74

Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases

Lu, C., Jiang, Y., Xu, W., & Bao, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05669-4 · Cited by 80

Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells

Suda, M., Shimizu, I., Katsuumi, G., Hsiao, C. L., Yoshida, Y., Matsumoto, N., Yoshida, Y., Katayama, A., Wada, J., Seki, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10522-3 · Cited by 70

Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

Wang, L., Zhu, X.-M., & Yao, Y.-M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02797 · Cited by 68

Mitochondrial health, the epigenome and healthspan

Aon, M. A., Cortassa, S., Juhaszova, M., & Sollott, S. J. (2016) · Clinical Science · doi:10.1042/cs20160002 · Cited by 66

MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6

Dang, Y., Wang, X., Hao, Y., Zhang, X., Zhao, S., Ma, J., Qin, Y., & Chen, Z. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0163-8 · Cited by 66

Characterization of the structure and analysis of the anti-oxidant effect of microalga Spirulina platensis polysaccharide on Caenorhabditis elegans mediated by modulating microRNAs and gut microbiota

Chen, Y., Wan, X., Wu, D., Ouyang, Y., Gao, L., Chen, Z., El-Seedi, H. R., Wang, M.-F., Chen, X., & Zhao, C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.041 · Cited by 64

To control or to be controlled? Dual roles of CDK2 in DNA damage and DNA damage response

Liu, Q., Gao, J., Zhao, C., Guo, Y., Wang, S., Shen, F., Xing, X., & Luo, Y. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102702 · Cited by 63

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

Yokoyama, M., Shimizu, I., Nagasawa, A., Yoshida, Y., Katsuumi, G., Wakasugi, T., Hayashi, Y., Ikegami, R., Suda, M., Ota, Y., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.02.010 · Cited by 63

Role of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DNA damage response

Ramos, F., Villoria, M. T., Alonso‐Rodríguez, E., & Clemente‐Blanco, A. (2019) · Cell Stress · doi:10.15698/cst2019.03.178 · Cited by 61

Oxidative DNA damage is associated with inflammatory response, insulin resistance and microvascular complications in type 2 diabetes

Tatsch, E., de Carvalho, J. A. M., Hausen, B. S., Bollick, Y. S., Torbitz, V. D., Duarte, T., Scolari, R., Duarte, M. M. M. F., Londero, S. W. K., Vaucher, R. D. A., et al. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.10.003 · Cited by 58

Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis

Jang, J. E., Ko, M. S., Yun, J.-Y., Kim, M., Kim, J. H., Park, H. S., Kim, A.-R., Kim, H.-J., Kim, B. J., Ahn, Y. E., et al. (2016) · Diabetes · doi:10.2337/db15-1624 · Cited by 59

Genome instability syndromes caused by impaired DNA repair and aberrant DNA damage responses

Terabayashi, T., & Hanada, K. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9429-x · Cited by 61

Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies

Fenech, M. F., Bull, C. F., & van Klinken, B. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.004 · Cited by 58

DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease

Wang, H., Lautrup, S., Caponio, D., Zhang, J., & Fang, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136748 · Cited by 55

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Sun, X., & Feinberg, M. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.693067 · Cited by 56

DNA Damage Response and Metabolic Reprogramming in Health and Disease

Chatzidoukaki, O., Goulielmaki, E., Schumacher, B., & Garinis, G. A. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.018 · Cited by 58

Age at menopause and mortality in Taiwan: A cohort analysis

Shen, T.-Y., Strong, C., & Yu, T. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.04.008 · Cited by 54

PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes—Implications for UV-Induced DNA Repair and Photocarcinogenesis

Hegedűs, C., Boros, G., Fidrus, E., Kis, G. N., Antal, M., Juhász, T., Janka, E. A., Jankó, L., Paragh, G., Emri, G., et al. (2019) · Cancers · doi:10.3390/cancers12010005 · Cited by 51

Time-restricted feeding regulates molecular mechanisms with involvement of circadian rhythm to prevent metabolic diseases

Zeb, F., Wu, X., Fatima, S., Zaman, M. H., Khan, S. A., Safdar, M., Alam, I., & Feng, Q. (2021) · Nutrition · doi:10.1016/j.nut.2021.111244 · Cited by 51

DNA damage protection: an excellent application of bioactive compounds

Kaur, P., Purewal, S. S., Sandhu, K. S., & Kaur, M. (2019) · Bioresources and Bioprocessing · doi:10.1186/s40643-019-0237-9 · Cited by 50

Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?

Zaki‐Dizaji, M., Akrami, S. M., Azizi, G., Abolhassani, H., & Aghamohammadi, A. (2018) · Inflammation Research · doi:10.1007/s00011-018-1142-y · Cited by 49

Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis

Espinoza‐Derout, J., Shao, X. M., Bankole, E., Hasan, K. M., Mtume, N., Liu, Y., Sinha‐Hikim, A. P., & Friedman, T. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00320 · Cited by 47

Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates

Yang, H., Zhang, Q., Zhang, B., Zhao, Y., & Wang, N. (2023) · Marine Drugs · doi:10.3390/md21030144 · Cited by 44

DNA damage response signaling: A common link between cancer and cardiovascular diseases

Nikfarjam, S., & Singh, K. K. (2022) · Cancer Medicine · doi:10.1002/cam4.5274 · Cited by 45

Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin

Dong, C., West, K. L., Tan, X. Y., Li, J., Ishibashi, T., Yu, C., Sy, S. M.-H., Leung, J. W. C., & Huen, M. S. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002193117 · Cited by 47

‘Obesageing’

Ghosh, S., Sinha, J. K., & Raghunath, M. (2019) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_2120_18 · Cited by 42

Role of smooth muscle cell p53 in pulmonary arterial hypertension

Wakasugi, T., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Suda, M., Katsuumi, G., Nakao, M., Hoyano, M., Kashimura, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212889 · Cited by 41

Long non‐coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer

Hu, C.-Y., Chen, J., Qin, X.-H., You, P., Ma, J., Zhang, J., Zhang, H., & Xu, J. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01891-0 · Cited by 40

Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese Women

Włodarczyk, M., Jabłonowska-Lietz, B., Olejarz, W., & Nowicka, G. (2018) · Nutrients · doi:10.3390/nu10050578 · Cited by 41

Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity

Abolhassani, H., Wang, Y., Hammarström, L. L. G., & Pan‐Hammarström, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720025 · Cited by 39

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

Kaminsky, N., Bihari, O., Kanner, S., & Barzilai, A. (2016) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.04.003 · Cited by 38

DNA: Damage and Repair Mechanisms in Humans

Ambekar, S. S. (2017) · Global Journal of Pharmacy & Pharmaceutical Sciences · doi:10.19080/gjpps.2017.03.555613 · Cited by 39

Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

Wei, X., & Yin, H. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1040009 · Cited by 37

Detection of DNA double‐strand breaks by pulsed‐field gel electrophoresis

Kawashima, Y., Yamaguchi, N., Teshima, R., Narahara, H., Yamaoka, Y., Anai, H., Nishida, Y., & Hanada, K. (2016) · Genes to Cells · doi:10.1111/gtc.12457 · Cited by 37

Activation of nuclear β-catenin/c-Myc axis promotes oxidative stress injury in streptozotocin-induced diabetic cardiomyopathy

Liu, P., Su, J., Song, X., & Wang, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.027 · Cited by 36

Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice

Katsuumi, G., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Suda, M., Wakasugi, T., Nakao, M., & Minamino, T. (2018) · International Heart Journal · doi:10.1536/ihj.17-313 · Cited by 37

Regulatory mechanisms of Sesn2 and its role in multi-organ diseases

Wang, J., Wang, S., Xiao, M., Zhang, J., Wang, J., Guo, Y., Tang, Y., & Gu, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105331 · Cited by 36

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging

Martin, B., Chadwick, W., Janssens, J., Premont, R. T., Schmalzigaug, R., Becker, K. G., Lehrmann, E., Wood, W. H., Zhang, Y., Siddiqui, S., et al. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00191 · Cited by 34

Pathogenesis of Cancer: Cancer Reparative Trap

Bukhtoyarov, O. V., & Самарин, Д. М. (2015) · Journal of Cancer Therapy · doi:10.4236/jct.2015.65043 · Cited by 37

Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes

Lafosse, A., Dufeys, C., Beauloye, C., Horman, S., & Dufrane, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168058 · Cited by 34

Deep-Learning-Assisted Assessment of DNA Damage Based on Foci Images and Its Application in High-Content Screening of Lead Compounds

Chen, X., Xun, D., Zheng, R., Zhao, L., Lu, Y., Huang, J., Wang, R., & Wáng, Y. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03741 · Cited by 33

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Huang, R., Liu, X., Li, H., Zhou, Y., & Zhou, P. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00417-z · Cited by 32

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Veitia, R. A., Govindaraju, D. R., Bottani, S., & Birchler, J. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.006 · Cited by 32

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Huang, Y., Xiao, L., Xu, S., Zu, D., Liu, H., He, H., Bao, Q., He, Y., Liang, C., Shi, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.012 · Cited by 30

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

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Tay, V. S. Y., Devaraj, S., Koh, T., Ke, G., Crasta, K., & Ali, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-54554-8 · Cited by 31

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Levakov, G., Kaplan, A., Meir, A. Y., Rinott, E., Tsaban, G., Zelicha, H., Blüher, M., Ceglarek, U., Stümvoll, M., Shelef, I., et al. (2023) · eLife · doi:10.7554/elife.83604 · Cited by 27

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Lee, M., Kim, D., Choi, E. J., Song, J. H., Kang, J. Y., Lee, K. W., & Chang, J. Y. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112681 · Cited by 26

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Carotenuto, F., Albertini, M. C., Coletti, D., Vilmercati, A., Campanella, L., Darżynkiewicz, Z., & Teodori, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050752 · Cited by 26

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Guevara, A. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.123699652

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Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State

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Marconi, D., Ranfley, H., Menck, C. F. M., Ferreira, C. P., & Câmara, N. O. S. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00018-5 · Cited by 1

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