Altered Myocardial Calcium Cycling and Energetics in Heart Failure—A Rational Approach for Disease Treatment
Open accessAbstract
Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo)plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.
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- Authors
- Gorski, P. A., Ceholski, D. K., & Hajjar, R. J.
- Affiliations
- Mount Sinai Hospital (US)
- Corresponding author
- Hajjar, Roger J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 21
- Issue
- 2
- Pages
- 183-194
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4338997
- OpenAlex
- W2096322772
- Cited by
- 213
- References
- 138
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 19 · 2023: 24 · 2022: 23 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 16 · 2015: 4
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P20HL100396, P50HL112324, R01HL117505)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- heart failure, calcium homeostasis, excitation-contraction coupling, myocardial energy metabolism, SERCA2a, gene therapy, calcium handling proteins, cardiomyocyte function
- MeSH terms
- Calcium-Transporting ATPases, Animals, Calcium, Heart Failure, Humans, Myocardium
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