Cited by 213Cardiac electrophysiology and arrhythmiasCardiovascular Function and Risk FactorsMitochondrial Function and Pathology

Altered Myocardial Calcium Cycling and Energetics in Heart Failure—A Rational Approach for Disease Treatment

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Gorski, Przemek A., Ceholski, Delaine K., Hajjar, Roger J.·2015·Cell Metabolism

Abstract

Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo)plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.

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Crossref · 10.1016/j.cmet.2015.01.005

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Authors
Gorski, P. A., Ceholski, D. K., & Hajjar, R. J.
Affiliations
Mount Sinai Hospital (US)
Corresponding author
Hajjar, Roger J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2015-02
Volume
21
Issue
2
Pages
183-194
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2096322772
Cited by
213
References
138
Citations by year
2026: 11 · 2025: 26 · 2024: 19 · 2023: 24 · 2022: 23 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 16 · 2015: 4
FWCI
3.10
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (P20HL100396, P50HL112324, R01HL117505)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
heart failure, calcium homeostasis, excitation-contraction coupling, myocardial energy metabolism, SERCA2a, gene therapy, calcium handling proteins, cardiomyocyte function
MeSH terms
Calcium-Transporting ATPases, Animals, Calcium, Heart Failure, Humans, Myocardium

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