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Cited by 317

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

Open access
Jantsch, Jonathan, Schatz, Valentin, Friedrich, Diana, Schröder, Agnes, Kopp, Christoph, Siegert, Isabel, Maronna, Andreas, Wendelborn, David, Linz, Peter, Binger, Katrina J., Gebhardt, Matthias, Heinig, Matthias, Neubert, Patrick, Fischer, Fabian, Teufel, Stefan, David, Jean-Pierre, Neufert, Clemens, Cavallaro, Alexander, Rakova, Natalia, Küper, Christoph, Beck, Franz-Xaver, Neuhofer, Wolfgang, Muller, Dominik N., Schuler, Gerold, Uder, Michael, Bogdan, Christian, Luft, Friedrich C., Titze, Jens·2015·Cell Metabolism
DOI 10.1016/j.cmet.2015.02.003
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Abstract

Summary Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na+ concentrations is unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a model of skin-prone macrophage infection to test the hypothesis that skin-Na+ storage facilitates antimicrobial host defense. Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)-dependent nuclear factor of activated T cells 5 (NFAT5) activation. This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na+ content in the skin by a high-salt diet boosted activation of macrophages in an Nfat5-dependent manner and promoted cutaneous antimicrobial defense. We suggest that the hypertonic microenvironment could serve as a barrier to infection.

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Metadata

Authors
Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K. J., Gebhardt, M., Heinig, M., Neubert, P., Fischer, F., Teufel, S., David, J.-P., Neufert, C., Cavallaro, A., Rakova, N., Küper, C., Beck, F.-X., Neuhofer, W., Muller, D. N., Schuler, G., Uder, M., Bogdan, C., Luft, F. C., & Titze, J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2015-03
Volume
21
Issue
3
Pages
493-501
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2015.02.003
OpenAlex
W2055323879
Cited by
317
References
43
FWCI
32.67
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense. https://app.cochat.ai/papers/10.1016/j.cmet.2015.02.003
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Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K. J., Gebhardt, M., Heinig, M., Neubert, P., Fischer, F., Teufel, S., David, J.-P., Neufert, C., Cavallaro, A., Rakova, N., . . . Titze, J. (2015). Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.02.003

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.