The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
Open accessAbstract
SUMMARY Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in colon cancer metabolism has been suggested but to date has not been evaluated. Using metabolomics, we investigated the metabolic influence that microbial biofilms have on colon tissues and the related occurrence of cancer. Patient-matched colon cancers and histologically normal tissues, with or without biofilms, were examined. We show the upregulation of polyamine metabolites in tissues from cancer hosts with significant enhancement of N1, N12-diacetylspermine in both biofilm positive cancer and normal tissues. Antibiotic treatment, which cleared biofilms, decreased N1, N12-diacetylspermine levels to those seen in biofilm negative tissues, indicating that host cancer and bacterial biofilm structures contribute to the polyamine metabolite pool. These results show that colonic mucosal biofilms alter the cancer metabolome, to produce a regulator of cellular proliferation and colon cancer growth potentially affecting cancer development and progression.
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788
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“C face and indicate disruption of the normal colon mucous barrier (Probert and Gibson, 2002; Shah and Swiatlo, 2008); in addition, biofilms have been associated with non-malignant pathologies such as inflammatory bowel disease (Swidsinski et al., 2005).”
BackgroundIs There a Difference in Survival between Right- versus Left-Sided Colon Cancers?
Meguid, R. A., Slidell, M. B., Wolfgang, C. L., Chang, D. C., & Ahuja, N. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0015-y · Cited by 546
González‐Domínguez, R., García, A., García‐Barrera, T., Barbas, C., & Gómez‐Ariza, J. L. (2014) · ELECTROPHORESIS · doi:10.1002/elps.201400196 · Cited by 119
Cited by
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
Metabolomics: beyond biomarkers and towards mechanisms
Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.25 · Cited by 2,829
Self-citationGut Bacteroides species in health and disease
Zafar, H., & Saier, M. H. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1848158 · Cited by 1,233
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science · doi:10.1126/science.aah3648 · Cited by 1,105
Self-citationMETLIN: A Technology Platform for Identifying Knowns and Unknowns
Guijas, C., Montenegro-Burke, J. R., Domingo-Almenara, X., Palermo, A., Warth, B., Hermann, G., Koellensperger, G., Huan, T., Uritboonthai, W., Aisporna, A. E., et al. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04424 · Cited by 927
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Metadata
- Authors
- Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., Santidrian, A. F., Felding, B. H., Ivanisevic, J., Cho, K., Wick, E. C., Hechenbleikner, E. M., Uritboonthai, W., Goetz, L., Casero, R. A., Pardoll, D. M., White, J. R., Patti, G. J., Sears, C. L., & Siuzdak, G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 21
- Issue
- 6
- Pages
- 891-897
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1503057784
- Cited by
- 351
- References
- 4
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., Santidrian, A. F., Felding, B. H., Ivanisevic, J., Cho, K., Wick, E. C., Hechenbleikner, E. M., Uritboonthai, W., Goetz, L., Casero, R. A., Pardoll, D. M., White, J. R., Patti, G. J., Sears, C. L., & Siuzdak, G. (2015). Metabolism Links Bacterial Biofilms and Colon Carcinogenesis. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.04.011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
