Cited by 303Gut microbiota and healthPsoriasis: Treatment and PathogenesisAdipokines, Inflammation, and Metabolic Diseases

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The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

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Garidou, Lucile, Pomié, Céline, Klopp, Pascale, Waget, Aurélie, Charpentier, Julie, Aloulou, Meryem, Giry, Anaïs, Serino, Matteo, Stenman, Lotta, Lahtinen, Sampo, Dray, Cedric, Iacovoni, Jason S., Courtney, Michael, Collet, Xavier, Amar, Jacques, Servant, Florence, Lelouvier, Benjamin, Valet, Philippe, Eberl, Gérard, Fazilleau, Nicolas, Douin-Echinard, Victorine, Heymes, Christophe, Burcelin, Rémy·2015·Cell Metabolism

DOI 10.1016/j.cmet.2015.06.001

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Abstract

A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic phenotype was mimicked in RORγt-deficient mice, which lack IL17 and IL22 function, and in the adoptive transfer experiment of T cells from RORγt-deficient mice into Rag1-deficient mice. We conclude that the microbiota of the ileum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease.

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Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
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Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
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Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
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Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
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Authors: Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., Dray, C., Iacovoni, J. S., Courtney, M., Collet, X., Amar, J., Servant, F., Lelouvier, B., Valet, P., Eberl, G., Fazilleau, N., Douin-Echinard, V., Heymes, C., & Burcelin, R.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Institut Pasteur (FR)
Corresponding author: Garidou, Lucile
Burcelin, Rémy
ORCID: Garidou, Lucile
Klopp, Pascale
Aloulou, Meryem
Amar, Jacques
Servant, Florence
Lelouvier, Benjamin
Valet, Philippe
Eberl, Gérard
Fazilleau, Nicolas
Heymes, Christophe
Burcelin, Rémy
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2015-07
Volume: 22
Issue: 1
Pages: 100-112
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2015.06.001
OpenAlex: W1483529702
Cited by: 303
References: 49
Citations by year: 2026: 12 · 2025: 17 · 2024: 24 · 2023: 32 · 2022: 29 · 2021: 50 · 2020: 23 · 2019: 30 · 2018: 20 · 2017: 34 · 2016: 25 · 2015: 7
FWCI: 12.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: gut microbiota, RORγt, Th17 cells, high-fat diet, metabolic disorders, metabolic inflammation, lamina propria, antigen-presenting cells, IL-17, IL-22, adoptive T cell therapy, Rag1-deficient mice
MeSH terms: Gastrointestinal Microbiome, Animals, Cells, Cultured, Diabetes Mellitus, Type 2, Gene Expression Regulation, Ileum, Immunity, Male, Obesity, CD4-Positive T-Lymphocytes, CD4 Antigens, Gene Deletion, Interleukin-17, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Diet, High-Fat

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The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

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