The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease
Open accessAbstract
A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic phenotype was mimicked in RORγt-deficient mice, which lack IL17 and IL22 function, and in the adoptive transfer experiment of T cells from RORγt-deficient mice into Rag1-deficient mice. We conclude that the microbiota of the ileum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease.
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“Insulin resistance that is induced through a high-fat diet is associated with reduced levels of T helper 17 (TH17) cells that are positive for IL-17 and retinoic acid receptor-related orphan receptor γt (RORγt)112.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [112]
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Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Self-citationInduction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
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Rodríguez-Arellano, S. N., González-Gómez, J. P., Aguirre-Sánchez, J. R., Gómez‐Gil, B., Barrón‐Cabrera, E., Cháidez, C., & Vergara-Jiménez, M. D. J. (2026) · Nutrients · doi:10.3390/nu18213508
Silvestri, A., Gil‐Gómez, A., Vitale, M., Braga, D., Demitri, C., Brescia, P., Madaghiele, M., Spadoni, I., Jones, B., Fornasa, G., et al. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.10528693
Metadata
- Authors
- Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., Dray, C., Iacovoni, J. S., Courtney, M., Collet, X., Amar, J., Servant, F., Lelouvier, B., Valet, P., Eberl, G., Fazilleau, N., Douin-Echinard, V., Heymes, C., & Burcelin, R.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Corresponding author
- Garidou, Lucile
- Burcelin, Rémy
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 22
- Issue
- 1
- Pages
- 100-112
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1483529702
- Cited by
- 303
- References
- 49
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 24 · 2023: 32 · 2022: 29 · 2021: 50 · 2020: 23 · 2019: 30 · 2018: 20 · 2017: 34 · 2016: 25 · 2015: 7
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, RORγt, Th17 cells, high-fat diet, metabolic disorders, metabolic inflammation, lamina propria, antigen-presenting cells, IL-17, IL-22, adoptive T cell therapy, Rag1-deficient mice
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cells, Cultured, Diabetes Mellitus, Type 2, Gene Expression Regulation, Ileum, Immunity, Male, Obesity, CD4-Positive T-Lymphocytes, CD4 Antigens, Gene Deletion, Interleukin-17, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Diet, High-Fat
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