Are Metformin Doses Used in Murine Cancer Models Clinically Relevant

Metformin: from mechanisms of action to therapies

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Clinical pharmacokinetics of metformin

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

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Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

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Metformin Action: Concentrations Matter

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Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

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Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth

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Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

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Serine deprivation enhances antineoplastic activity of biguanides

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Cellular and Molecular Mechanisms of Metformin Action

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Mitochondrial Metabolism as a Target for Cancer Therapy

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Metformin: update on mechanisms of action and repurposing potential

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Modulating the therapeutic response of tumours to dietary serine and glycine starvation

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Hallmarks of cancer stem cell metabolism

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Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

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Metformin Inhibits Hepatic Mtorc1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

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Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

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A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

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Metformin: Is it a drug for all reasons and diseases?

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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

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PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs

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Hyperinsulinaemia in cancer

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Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

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Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus

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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

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Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

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Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

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Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

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Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice

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Metformin and berberine, two versatile drugs in treatment of common metabolic diseases

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AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

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The effects of metformin on gut microbiota and the immune system as research frontiers

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A Randomized Phase II Study of Metformin plus Paclitaxel/Carboplatin/Bevacizumab in Patients with Chemotherapy-Naïve Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer

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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

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Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway

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Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

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Syrosingopine sensitizes cancer cells to killing by metformin

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Lac-Phe mediates the effects of metformin on food intake and body weight

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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

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Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

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GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-Phosphate

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Metformin as a Therapeutic Target in Endometrial Cancers

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Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models

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Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism

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A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer

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Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

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The Mechanism of Action of Biguanides: New Answers to a Complex Question

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Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial

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Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

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New Insights Into the Anti-Diabetic Actions of Metformin: From the Liver to the Gut

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Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

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Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

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Metformin targets mitochondrial complex I to lower blood glucose levels

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STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

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Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice

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Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

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Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase

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Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

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Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

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The Impact of Metformin on Tumor-Infiltrated Immune Cells: Preclinical and Clinical Studies

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Targeting liver stage malaria with metformin

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Metformin and ovarian cancer: the evidence

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Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

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Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

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Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathway

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Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them

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A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects

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Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium

Li, Y., Gappy, S. S., Liu, X., Sassalos, T. M., Zhou, T., Hsu, A., Zhang, A., Edwards, P. A., Gao, H., & Qiao, X. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268451 · Cited by 37 · see citing works

Targeting Hypoxia-Inducible Factor-1α for the Management of Hepatocellular Carcinoma

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The Liver Circadian Clock Modulates Biochemical and Physiological Responses to Metformin

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Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

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Biguanides enhance antifungal activity against Candida glabrata

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