Metformin as a Tool to Target Aging

Cited by (1,150)

Items 601–700 of 1,150

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3. Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis
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4. The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans
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5. Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle‐Aged Wistar Female Rats
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6. Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration
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7. Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy
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8. Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies
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9. Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis
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10. The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment
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11. Changes in M6A methylation: A key factor in the vicious cycle of flora -gut aging
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12. The impact of metformin on mortality in patients with type 2 diabetes mellitus: a prospective cohort study
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13. Cardiovascular Safety and Benefits of Noninsulin Antihyperglycemic Drugs for the Treatment of Type 2 Diabetes Mellitus—Part 1
    Srikanth Yandrapalli, George P. Jolly, Adam M. Horblitt, Gayatri Pemmasani, Abdallah Sanaani, Wilbert S. Aronow, William H. Frishman · 2020 · Cardiology in Review
14. Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment
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15. The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study
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16. Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample
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17. Combined Effects of Methoprene and Metformin on Reproduction, Longevity, and Stress Resistance inAnastrepha ludens(Diptera: Tephritidae): Implications for the Sterile Insect Technique
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18. Translational Geroscience: Challenges and Opportunities for Geriatric Medicine
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19. Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy
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20. Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome
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21. Metformin Modifies the Gut Microbiota of Mice Infected with Helicobacter pylori
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22. The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
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23. Low Social Engagement and Risk of Death in Older Adults
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24. Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration
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25. Association between prescription drugs and all‐cause mortality risk in the UK population
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26. From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy
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27. Emerging Interventions for Elderly Patients—The Promise of Regenerative Medicine
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28. DDS promotes longevity through a microbiome-mediated starvation signal
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29. Comparing anti–aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease
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30. The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults
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31. Reversing age-associated arterial dysfunction: insight from preclinical models
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32. Phosphoproteome profiling of mouse liver during normal aging
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33. Metformin: not only per os
    Lev M. Berstein · 2018 · Expert Review of Endocrinology & Metabolism
34. Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations
    Tesfahun Dessale Admasu, Krishna Chaithanya Batchu, Li Fang Ng, Amaury Cazenave‐Gassiot, Markus Rene Wenk, Jan Gruber · 2018 · Scientific Data
35. The Role of the National Institute on Aging in the Development of the Field of Geroscience
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36. Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging
    Paul D. Robbins, Laura J. Niedernhofer · 2017 · Aging Cell
37. Ethical perspectives on advances in biogerontology
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38. Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases
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39. Progress in anti-ageing drug research for age-related diseases: A review
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40. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain
    Polyxeni Nikolakopoulou, Antonios Chatzigeorgiou, Ioannis Kourtzelis, Louiza Toutouna, Jimmy Rusdian Masjkur, Carina Arps‐Forker, Steven Poser, Jan Rozman, Birgit Rathkolb, Juan Antonio Aguilar‐Pimentel et al. · 2018 · Scientific Reports
41. Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies
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42. Metabolic Regulation of Cardiovascular Aging
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43. Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
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44. A mechanistic analysis of metformin's biphasic effects on lifespan and healthspan in C. elegans: Elixir in youth, poison in elder
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45. Metformin acts on miR-181a-5p/PAI-1 axis in stem cells providing new strategies for improving age-related osteogenic differentiation decline
    Guanhao Hong, Yulan Zhou, Shukai Yang, Shouquan Yan, Jiaxu Lu, Bo Xu, Zeyu Zhan, Hua-sheng Jiang, Bo Wei, Jiafeng Wang · 2024 · Stem Cells
46. Risk factors for bone fractures in type 2 diabetes and the impact of once-weekly exenatide: insights from an EXSCEL post-hoc analysis
    Ernesto Maddaloni, Ruth L. Coleman, Rury R. Holman · 2025 · Diabetes Research and Clinical Practice
47. Integrin β1-Mediated Cell–Cell Adhesion Augments Metformin-Induced Anoikis
    Tingting An, Zhiming Zhang, Yuhuang Li, Jianqiao Yi, Wenhua Zhang, Deshi Chen, Juan Ao, Zhi‐Xiong Jim Xiao, Yong Yi · 2019 · International Journal of Molecular Sciences
48. Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity
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49. Effects of Aging on Metabolic Characteristics of Human B Cells
    Daniela Frasca, Suresh Pallikkuth, Savita G. Pahwa · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes
50. High-dose metformin (420 mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis
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51. Bridging the gap between the laboratory and the clinic for patients with sarcopenia
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52. It is Time to Embrace 21st-Century Medicine
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53. Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”
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54. Aging: a New Perspective on an Old Issue
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55. Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment
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56. Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age
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57. MetfOrmin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC): randomized clinical trial protocol
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58. From clock to clock: Therapeutic target discovery for aging and age-related diseases
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59. Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential
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60. Senotherapeutics and HIV-1 Persistence
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61. Hereditary syndromes with signs of premature aging
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62. Mitochondrial dysfunction in mandibular hypoplasia, deafness and progeroid features with concomitant lipodystrophy (MDPL) patients
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63. Hungering for Immortality.
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64. A Pragmatic Approach to Introducing Translational Geroscience Into the Clinic: A Paradigm Based on the Incremental Progression of Aging-Related Clinical Research
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65. The Endocrinology of Aging: A Key to Longevity “Great Expectations”
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66. Cellular senescence as a therapeutic target for aging intervention
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68. Geroscience
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69. Immunity, stem cells, and aging
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70. Metformin-mediated protection against Immunosenescence in diabetic cardiomyopathy: The potential roles of GDF-15 and klotho proteins
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72. Repurposing Drugs for Treatment of Age-Related Macular Degeneration
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73. An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
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74. New approach to generating insights for aging research based on literature mining and knowledge integration
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75. Incidence, factors related to presentation, course and mortality of metformin-associated lactic acidosis in the healthcare area of a tertiary hospital
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76. Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?
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77. Advantages of the use of metformin in patients with impaired uric acid metabolism
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85. Energy Metabolism and Metformin: Effects on Ischemia-Reperfusion Injury in Kidney Transplantation
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94. Glucosuria and all-cause mortality among general screening participants
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95. Signal Transduction Pathways in Ageing
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