Immunity, stem cells, and aging

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

SATELLITE CELL OF SKELETAL MUSCLE FIBERS

Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

Mechanisms and Functional Implications of Adult Neurogenesis

Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Senescence and aging: Causes, consequences, and therapeutic avenues

McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233 · see citing works

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works

Metformin as a tool to target aging

Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096 · see citing works

The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

The aging of the immune system

Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Autophagy maintains the metabolism and function of young and old stem cells

Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E., & Passegué, E. (2017) · Nature · doi:10.1038/nature21388 · Cited by 896 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

mTOR inhibition improves immune function in the elderly

Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786 · see citing works

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

Mendelson, A., & Frenette, P. S. (2014) · Nature Medicine · doi:10.1038/nm.3647 · Cited by 783 · see citing works

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711 · see citing works

Rapamycin slows aging in mice

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 684 · see citing works

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2009) · Science Signaling · doi:10.1126/scisignal.2000559 · Cited by 680 · see citing works

A Role for Skin γδ T Cells in Wound Repair

Jameson, J., Ugarte, K., Chen, N., Yachi, P. P., Fuchs, E. V., Boismenu, R., & Havran, W. L. (2002) · Science · doi:10.1126/science.1069639 · Cited by 639 · see citing works

Role of p53 in the Regulation of Cellular Senescence

Mijit, M., Caracciolo, V., Melillo, A., Amicarelli, F., & Giordano, A. (2020) · Biomolecules · doi:10.3390/biom10030420 · Cited by 639 · see citing works

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

Nishino, J., Kim, I., Chada, K. K., & Morrison, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.017 · Cited by 623 · see citing works

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Weichhart, T. (2018) · Gerontology · doi:10.1159/000484629 · Cited by 596 · see citing works

Sexual-dimorphism in human immune system aging

Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584 · see citing works

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583 · see citing works

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

Florian, M. C., Dörr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, M., Filippi, M.-D., Hasenberg, A., Gunzer, M., Scharffetter-Kochanek, K., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.007 · Cited by 564 · see citing works

Targeted genome editing in human repopulating haematopoietic stem cells

Genovese, P., Schiroli, G., Escobar, G., Di Tomaso, T., Firrito, C., Calabria, A., Moi, D., Mazzieri, R., Bonini, C., Holmes, M. C., et al. (2014) · Nature · doi:10.1038/nature13420 · Cited by 555 · see citing works

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works

Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice

Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522 · see citing works

Dynamics of Myoblast Transplantation Reveal a Discrete Minority of Precursors with Stem Cell–like Properties as the Myogenic Source

Beauchamp, J. R., Morgan, J. E., Pagel, C. N., & Partridge, T. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.6.1113 · Cited by 513 · see citing works

Isolation of Adult Mouse Myogenic Progenitors

Sherwood, R. I., Christensen, J. L., Conboy, I. M., Conboy, M. J., Rando, T. A., Weissman, I. L., & Wagers, A. J. (2004) · Cell · doi:10.1016/j.cell.2004.10.021 · Cited by 491 · see citing works

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.034 · Cited by 484 · see citing works

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Carlson, M. E., Hsu, M., & Conboy, I. M. (2008) · Nature · doi:10.1038/nature07034 · Cited by 483 · see citing works

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, A., Ito, T. K., Pineda, V. V., LeTexier, N. J., Huang, H. Z., Sutlief, E., Tung, H., Vizzini, N., Chen, B., Smith, K., et al. (2016) · eLife · doi:10.7554/elife.16351 · Cited by 474 · see citing works

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell · doi:10.1111/acel.12170 · Cited by 445 · see citing works

The central role of muscle stem cells in regenerative failure with aging

Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works

Protein homeostasis and aging in neurodegeneration

Douglas, P. M., & Dillin, A. G. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005144 · Cited by 372 · see citing works

Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

Inomata, K., Aoto, T., Binh, N. T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.037 · Cited by 368 · see citing works

T cells and aging january 2002 update

Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00414.x · Cited by 349 · see citing works

Centrosome misorientation reduces stem cell division during ageing

Cheng, J., Türkel, N., Hemati, N., Fuller, M. T., Hunt, A. J., & Yamashita, Y. M. (2008) · Nature · doi:10.1038/nature07386 · Cited by 346 · see citing works

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., Rosenfeld, S. V., & Blagosklonny, M. V. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18486 · Cited by 344 · see citing works

Transcriptional and epigenetic regulation of autophagy in aging

Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 339 · see citing works

Aging and Immune Function: Molecular Mechanisms to Interventions

Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works

Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila

LaFever, L., & Drummond‐Barbosa, D. (2005) · Science · doi:10.1126/science.1111410 · Cited by 322 · see citing works

Age‐related differences in absolute numbers of skeletal muscle satellite cells

Gibson, M. C., & Schultz, E. (1983) · Muscle & Nerve · doi:10.1002/mus.880060807 · Cited by 321 · see citing works

A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging

Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0372 · Cited by 320 · see citing works

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation

Nishimura, E. K. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00855.x · Cited by 316 · see citing works

Late-life rapamycin treatment reverses age-related heart dysfunction

Flynn, J. M., O’Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12109 · Cited by 309 · see citing works

Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy

Brack, A. S., Bildsoe, H., & Hughes, S. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02602 · Cited by 308 · see citing works

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303 · see citing works

The role of mitochondria in stem cell fate and aging

Zhang, H., Menzies, K. J., & Auwerx, J. H. (2018) · Development · doi:10.1242/dev.143420 · Cited by 285 · see citing works

Cellular Senescence in Neurodegenerative Diseases

Martínez‐Cué, C., & Rueda, N. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00016 · Cited by 285 · see citing works

TGF-β signaling in the control of hematopoietic stem cells

Blank, U., & Karlsson, S. (2015) · Blood · doi:10.1182/blood-2014-12-618090 · Cited by 277 · see citing works

Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272 · see citing works

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 269 · see citing works

Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268 · see citing works

Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin

Keyes, B. E., Liu, S., Asare, A., Naik, S., Levorse, J., Polak, L., Lu, C. P., Nikolova, M., Pasolli, H. A., & Fuchs, E. (2016) · Cell · doi:10.1016/j.cell.2016.10.052 · Cited by 266 · see citing works

Age‐related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF‐like growth factor

Choi, N., Kim, J., Yang, D., Kim, Y., & Yoo, M. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00380.x · Cited by 256 · see citing works

Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses

Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works

Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective

Ezhilarasan, D. (2018) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2018.03.002 · Cited by 239 · see citing works

Cancer predisposition and hematopoietic failure in <i> Rad50 ^S/S </i> mice

Bender, C. F., Sikes, M. L., Sullivan, R., Huye, L. E., Le Beau, M. M., Roth, D. B., Mirzoeva, O. K., Oltz, E. M., & Petrini, J. H. J. (2002) · Genes &amp; Development · doi:10.1101/gad.1007902 · Cited by 213 · see citing works

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207 · see citing works

Autophagy in aging and longevity

Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 204 · see citing works

Effect of aging on stem cells

Ahmed, A. S. I., Sheng, M. H. ‐., Wasnik, S., Baylink, D. J., & Lau, K. ‐. W. (2017) · World Journal of Experimental Medicine · doi:10.5493/wjem.v7.i1.1 · Cited by 202 · see citing works

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities

Filippi, M., & Ghaffari, S. (2019) · Blood · doi:10.1182/blood-2018-10-808873 · Cited by 200 · see citing works

Adult stem cells: hopes and hypes of regenerative medicine

Dulak, J., Szade, K., Szade, A., Nowak, W. N., & Józkowicz, A. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2015_1023 · Cited by 191 · see citing works

mTOR signaling in stem and progenitor cells

Meng, D., Frank, A. R., & Jewell, J. L. (2018) · Development · doi:10.1242/dev.152595 · Cited by 191 · see citing works

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

Yang, L. C., Wang, L., Geiger, H., Cancelas, J. A., Mo, J., & Zheng, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610819104 · Cited by 184 · see citing works

The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche

Toledano, H., D’Alterio, C., Czech, B., Levine, E., & Jones, D. L. (2012) · Nature · doi:10.1038/nature11061 · Cited by 178 · see citing works

Autophagy is required for self-renewal and differentiation of adult human stem cells

Salemi, S., Yousefi, S., Constantinescu, M. A., Fey, M. F., & Simon, H. (2011) · Cell Research · doi:10.1038/cr.2011.200 · Cited by 175 · see citing works

Autophagy and Stem Cells: Self-Eating for Self-Renewal

Chang, N. C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00138 · Cited by 174 · see citing works

Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production

O’Mahony, L., Holland, J., Jackson, J., Feighery, C., Hennessy, T. P. J., & Mealy, K. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00641.x · Cited by 173 · see citing works

The role of DNA damage repair in aging of adult stem cells

Kenyon, J. D., & Gerson, S. L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1064 · Cited by 150 · see citing works

Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142 · see citing works

The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome

Peth, A., Nathan, J. A., & Goldberg, A. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482570 · Cited by 140 · see citing works

Vascular‐derived TGF‐β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain

Pineda, J. R., Daynac, M., Chicheportiche, A., Cebrián‐Silla, A., Sii-Felice, K., García‐Verdugo, J. M., Boussin, F. D., & Mouthon, M. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202197 · Cited by 134 · see citing works

Oxidative Stress in Stem Cell Aging

Chen, F., Liu, Y., Wong, N.-K., Xiao, J., & So, K. (2017) · Cell Transplantation · doi:10.1177/0963689717735407 · Cited by 134 · see citing works

The Arf/p53 Pathway in Cancer and Aging

Matheu, A., Maraver, A., & Serrano, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6851 · Cited by 129 · see citing works

Epigenetic regulation of aging stem cells

Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 128 · see citing works

Surviving change: the metabolic journey of hematopoietic stem cells

Kohli, L., & Passegue, E. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.001 · Cited by 127 · see citing works

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu, Y., Weng, W., Gao, R., & Liu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4598167 · Cited by 116 · see citing works

Adult Stem Cells and Diseases of Aging

Boyette, L., & Tuan, R. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3010088 · Cited by 108 · see citing works

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16 ^Ink4a and Arf

Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., & Dorshkind, K. (2008) · Genes &amp; Development · doi:10.1101/gad.1715808 · Cited by 102 · see citing works

The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila

Park, J., Kim, Y.-S., & Yoo, M. (2009) · Aging · doi:10.18632/aging.100054 · Cited by 94 · see citing works

Pharmacological Regulation of Oxidative Stress in Stem Cells

Lee, J., Cho, Y. S., Jung, H., & Choi, I. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4081890 · Cited by 94 · see citing works

Ageing as developmental decay: insights from p16INK4a.

Martin, N., Beach, D., & Gil, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.008 · Cited by 76 · see citing works

Stem cells, mitochondria and aging

Ahlqvist, K. J., Suomalainen, A., & Hämäläinen, R. H. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.014 · Cited by 76 · see citing works

Epigenomic drivers of immune dysfunction in aging

Keenan, C. R., & Allan, R. S. (2018) · Aging Cell · doi:10.1111/acel.12878 · Cited by 76 · see citing works

Causes and Mechanisms of Hematopoietic Stem Cell Aging

Lee, J., Yoon, S. R., Choi, I., & Jung, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061272 · Cited by 76 · see citing works

Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin

Rittié, L., Stoll, S. W., Kang, S., Voorhees, J. J., & Fisher, G. J. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00526.x · Cited by 75 · see citing works

Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.

Takeda, K., Kinoshita, I., Shimizu, Y., Matsuno, Y., Shichinohe, T., & Dosaka‐Akita, H. (2011) · PubMed · Cited by 73 · see citing works

The effects of ageing on the colonic bacterial microflora in adults

Enck, P., Zimmermann, K., Rusch, K., Schwiertz, A., Klosterhalfen, S., & Frick, J.-S. (2009) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0028-1109055 · Cited by 68 · see citing works

Epigenetic Regulation of Bone Marrow Stem Cell Aging: Revealing Epigenetic Signatures associated with Hematopoietic and Mesenchymal Stem Cell Aging

Cakouros, D., & Gronthos, S. (2018) · Aging and Disease · doi:10.14336/ad.2017.1213 · Cited by 68 · see citing works

Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesis

Famili, F., Naber, B. A. E., Vloemans, S. A., de Haas, E. F. E., Tiemessen, M. M., & Staal, F. J. T. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.326 · Cited by 54 · see citing works

Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance

Khacho, M., & Slack, R. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7228 · Cited by 53 · see citing works

The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines

Min, E., Kim, I., LEE, J., Kim, E., Choi, Y., & Nam, T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2426 · Cited by 51 · see citing works

Increased Arf/p53 activity in stem cells, aging and cancer

Carrasco‐García, E., Moreno, M., Moreno‐Cugnon, L., & Matheu, A. (2017) · Aging Cell · doi:10.1111/acel.12574 · Cited by 51 · see citing works

Niches for hematopoietic stem cells and immune cell progenitors

Sugiyama, T., Omatsu, Y., & Nagasawa, T. (2018) · International Immunology · doi:10.1093/intimm/dxy058 · Cited by 51 · see citing works

Dietary restriction enhances germline stem cell maintenance

Mair, W. B., McLeod, C. J., Wang, L., & Jones, D. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00602.x · Cited by 47 · see citing works

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a

Berent-Maoz, B., Montecino-Rodriguez, E., Signer, R. A. J., & Dorshkind, K. (2012) · Blood · doi:10.1182/blood-2011-12-400002 · Cited by 46 · see citing works

Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm

Liang, R. H.-S., & Ghaffari, S. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.11.006 · Cited by 45 · see citing works

Anemia in the elderly.

Berliner, N. (2013) · Europe PMC (PubMed Central) · Cited by 35 · see citing works

Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging

Singh, A. K., Althoff, M. J., & Cancelas, J. A. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0128-6 · Cited by 27 · see citing works

Stem Cells and Aging

Koliakos, G. (2016) · Rejuvenation Research · doi:10.1089/rej.2016.1809 · Cited by 9 · see citing works

The biology of ageing and the omics revolution

Harries, L. W., & Goljanek‐Whysall, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9776-2 · Cited by 5 · see citing works

Biology of aging: New models, new methods

Cellerino, A., & Tozzini, E. T. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.024 · Cited by 2 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Aging disrupts spatiotemporal regulation of germline stem cells and niche integrity

Urman, M. A., John, N. S., Jung, T., & Lee, C. (2023) · Biology Open · doi:10.1242/bio.060261 · Cited by 14 · see citing works

Regulation of cancer stemness, cell signaling, reactive oxygen species, and microRNAs in cancer stem cells

Chengizkhan, G., Thangavelu, S. K., Muthusami, S., Banerjee, A., Pathak, S., Natarajan, G., Ramalingam, S., Queimado, L., Kumaran, R., & Ramachandran, I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13212-4.00026-x · Cited by 5 · see citing works

Tracing the cellular consequences of polyethylene microplastics: senescence and apoptosis in A549 and Raw 264.7 macrophage cells

Koner, S., & Seenivasan, R. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111868 · Cited by 4 · see citing works

Role of Stem Cells and Reactive Oxygen Species in Cancer

Ezhilarasan, D., Perumal, E., Balakrishnan, A., & Anbalagan, M. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_103-1 · Cited by 2 · see citing works

Age-dependent structural and morphological changes of the stem cell niche disrupt spatiotemporal regulation of stem cells and drive tissue disintegrationPreprint

Urman, M. A., John, N. S., & Lee, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.15.524122 · Cited by 2 · see citing works

Role of Stem Cells and Reactive Oxygen Species in Cancer

Ezhilarasan, D., Perumal, E., Balakrishnan, A., & Anbalagan, M. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_103

Stem cell dysfunction and rejuvenation strategies in ageing: emerging advances in regenerative medicine

Dinislam, K., Shamsi, A., Syed, T., Anwar, S., & Shahwan, M. J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1830358

Biology of aging: New models, new methods

Cellerino, A., & Tozzini, E. T. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.024 · Cited by 2 · see citing works

Stem Cell Aging

Rožman, P. J., Jazbec, K., & Jež, M. (2018) · InTech eBooks · doi:10.5772/intechopen.71764 · Cited by 3 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Mechanistic insights into stem cell aging: Pathways and processes

Fauzi, A., Wong, C. Z. E., Tee, P. Y. E., Yau, A. W. N., Rashid, E. A., Tang, Y. Q., & Chia, A. Y. Y. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112160 · Cited by 5 · see citing works

Stem cells and healthy aging

Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347 · see citing works