Metformin activates AMPK through the lysosomal pathway

Zhang, Chen-Song, Li, Mengqi, Ma, Teng, Zong, Yue, Cui, Jiwen, Feng, Jin-Wei, Wu, Yu-Qing, Lin, Shu-Yong +1 more·2016·Cell Metabolism

DOI 10.1016/j.cmet.2016.09.003

Cited by (280)

Items 101–200 of 280

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders
Sonja K. Soo, Paige D. Rudich, Annika Traa, Namasthée Harris-Gauthier, Hazel J. Shields, Jeremy M. Van Raamsdonk · 2020 · Mechanisms of Ageing and Development
Mechanisms of Preconditioning Exercise-Induced Neurovascular Protection in Stroke
Sherif S. Hafez, Zeina Eid, Sara Alabasi, Yasenya Darwiche, Sara Channaoui, David Charles Hess · 2021 · Journal of Stroke
Metformin: update on mechanisms of action on liver diseases
Gaoyi Ruan, Fangquan Wu, Dibang Shi, Hongxia Sun, Fangyan Wang, Changlong Xu · 2023 · Frontiers in Nutrition
The direct targets of metformin in diabetes and beyond
Luxia Yao, Lei Wang, Runshuai Zhang, Alexander A. Soukas, Lianfeng Wu · 2024 · Trends in Endocrinology and Metabolism
Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells
Yu Tai, Lanjun Li, Xuan Peng, Jun-Xue Zhu, Xi-Hai Mao, Nan Qin, Minghui Ma, Rong Huo, Yunlong Bai, Deli Dong · 2018 · Acta Pharmaceutica Sinica B
Metformin Exerts Antidepressant Effects by Regulated DNA Hydroxymethylation
Yufan Wang, Beibei Liu, Yang Yong, Yamin Wang, Zhong Zhao, Zhigang Miao, Jiangtao Zhu · 2019 · Epigenomics
Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders
Laura Mihaela Isop, Andrea Elena Neculau, Radu Dan Necula, Cristian Kakucs, Marius Moga, Lorena Dima · 2023 · Pharmaceuticals
The Function of Metformin in Aging-Related Musculoskeletal Disorders
Yanhong Song, Ziyi Wu, Ping Zhao · 2022 · Frontiers in Pharmacology
Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity
Моргунова Галина Васильевна, А. А. Клебанов · 2019 · Cell Biochemistry and Function
Targeted nanotherapeutics for the treatment of Helicobacter pylori infection
Rute Chitas, Diana R. Fonseca, Paula Parreira, Maria Cristina L. Martins · 2024 · Journal of Biomedical Science
Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review
Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou, Baoan Chen · 2023 · Biomolecules
Metformin Promotes Beclin1-Dependent Autophagy to Inhibit the Progression of Gastric Cancer
Su Liu, Chao Yue, Huanqiu Chen, Yun Chen, Gang Li · 2020 · OncoTargets and Therapy
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
Yuezhou Wang, Lei Zhang, Yanling Wei, Wei Huang, Li Li, Anan Wu, Anahita Dastur, Patricia Greninger, Walter M. Bray, Chen‐Song Zhang et al. · 2020 · Cell chemical biology
Protection by metformin against severe Covid-19: An in-depth mechanistic analysis
Nicolas F. Wiernsperger, Abdallah Al‐Salameh, Bertrand Cariou, Jean‐Daniel Lalau · 2022 · Diabetes & Metabolism
The Emerging Role of Metformin in the Treatment of Hepatocellular Carcinoma: Is There Any Value in Repurposing Metformin for HCC Immunotherapy?
Stavros P. Papadakos, Daniele Ferraro, Gabriele Carbone, Adam Enver Frampton, Giovanni Vennarecci, Stylianos Kykalos, Dimitriοs Schizas, Stamatios E Theocharis, Nikolaos Machairas · 2023 · Cancers
Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming
Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu et al. · 2023 · Cellular and Molecular Life Sciences
An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis
Magdalena Markowicz-Piasecka, Adrianna Sadkowska, Kristiina M. Huttunen, Maria Podsiedlik, Elżbieta Mikiciuk‐Olasik, Joanna Sikora · 2020 · European Journal of Pharmacology
Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
Wheeler Torres, Manuel Nava, Néstor Galbán, Yosselin Gómez, Valery Morillo, Milagros Rojas, Clímaco Cano, Maricarmen Chacín, Luis D’Marco, Yaneth Herazo-Beltrán et al. · 2020 · Current Pharmaceutical Design
Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets
Yadan Chen, Haiming Ma, Zhu Dasheng, Guowei Zhao, Lili Wang, Xiujuan Fu, Wei Chen · 2017 · PPAR Research
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP
Qianqian Zhang, Wenge Li, Yanting Zhu, Qingting Wang, Cui Zhai, Wenhua Shi, Wei Feng, Jian Wang, Xin Yan, Limin Chai et al. · 2021 · Molecular and Cellular Biochemistry
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Zhang, Yong-mei, Zong, Hai-chao, Qi, Ying-bei, Chang, Liu-liu, Gao, Ya-nan, Zhou, Ting, Yin, Tao, Liu, Meng, Pan, Kai-jun, Chen, Wen-gang et al. · 2023 · Molecular Psychiatry
Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination
Zhiguo Wang, Conghua Lu, Kejun Zhang, Caiyu Lin, Fang Wu, Xiaolin Tang, Di Wu, Yuanyao Dou, Rui Han, Yubo Wang et al. · 2022 · Frontiers in Molecular Biosciences
Metformin Suppresses Development of the Echinococcus multilocularis Larval Stage by Targeting the TOR Pathway
Julia A. Loos, Valeria A. Dávila, Klaus Brehm, Andrea C. Cumino · 2020 · Antimicrobial Agents and Chemotherapy
Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice
Jarinyaporn Naowaboot, Pritsana Piyabhan, Pholawat Tingpej, Narongsuk Munkong, Wason Parklak, Patchareewan Pannangpetch · 2018 · Asian Pacific Journal of Tropical Biomedicine
Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Ha Thu Nguyen, Andreas Wiederkehr, Claes B. Wollheim, Kyu‐Sang Park · 2024 · Experimental & Molecular Medicine
Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity
Su Hwan Park, J.H. Lee, Hye Jin Yun, Seok-Ho Kim, Jong‐Ho Lee · 2024 · Annals of Laboratory Medicine
Preoperative Oral Carbohydrate Reduces Postoperative Insulin Resistance by Activating AMP-Activated Protein Kinase after Colorectal Surgery
Mengyao Shi, Zunqi Hu, Dejun Yang, Qingping Cai, Zhenxin Zhu · 2020 · Digestive Surgery
Metformin Is Associated with Reduced Tissue Factor Procoagulant Activity in Patients with Poorly Controlled Diabetes
Marco Witkowski, Julian Friebel, Termeh Tabaraie, Sinah Grabitz, Andrea Dörner, Lena Taghipour, Kai Jakobs, Bernd Stratmann, Diethelm Tschoepe, Ulf Landmesser et al. · 2020 · Cardiovascular Drugs and Therapy
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways
Francesca Benedetti, Vincenzo Sorrenti, Alessandro Buriani, Stefano Fortinguerra, Giovanni Scapagnini, Davide Zella · 2020 · Viruses
Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation
Bin Zhang, Xuelian Zhang, Chenyang Zhang, Guibo Sun, Xiaobo Sun · 2021 · Pharmaceutical Research
Epigenetic regulation of Fructose‐1,6‐bisphosphatase 1 by host transcription factor Speckled 110 kDa during hepatitis B virus infection
Isha Sengupta, Payel Mondal, Amrita Sengupta, Atanu Mondal, Vipin Singh, Swagata Adhikari, Sinjini Dhang, Siddhartha Roy, Chandrima Das · 2022 · FEBS Journal
TBC1D23 mediates Golgi-specific LKB1 signaling
Yingfeng Tu, Qin Yang, Min Tang, Li Ping Gao, Yuanhao Wang, Jiuqiang Wang, Zhe Liu, Xiaoyu Li, Lejiao Mao, Rui zhen Jia et al. · 2024 · Nature Communications
Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons
Wenbing Chen, Jiang Chen, Ziyang Liu, Bin Luo, Tian Gang Zhou, Erkang Fei · 2020 · Brain Sciences
Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise
Adriana De Sousa Lages, Valentim Lopes, João Horta, João Espregueira‐Mendes, Renato Andrade, Alexandre Rebelo‐Marques · 2022 · International Journal of Molecular Sciences
Exploring the mechanism of metformin action in Alzheimer’s disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation
Xin Shi, Lingling Li, Zhiyao Liu, Fangqi Wang, Hailiang Huang · 2023 · Therapeutic Advances in Endocrinology and Metabolism
Gut Microbiota Brings a Novel Way to Illuminate Mechanisms of Natural Products in vivo
Peng Guo, Chongming Wu · 2017 · Chinese Herbal Medicines
Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis
Chen‐Song Zhang, Mengqi Li, Yue Zong, Sheng‐Cai Lin · 2018 · Methods in molecular biology
Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells
Shanshan Gou, Lu Qiu, Qiufang Yang, Peng Li, Xiaowen Zhou, Yixuan Sun, Xiuman Zhou, Wenshan Zhao, Wenjie Zhai, Guodong Li et al. · 2021 · Toxicology and Applied Pharmacology
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15
John W. R. Kincaid, Debra Rimmington, John A. Tadross, Irène Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen O’Rahilly, Anthony P. Coll · 2024 · Scientific Reports
Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway
Shiyong Wu, Hairong Zhang, Ningheng Chen, Chuang Zhang, Xueli Guo · 2020 · Journal of drug targeting
The elevated toxicity of the biodegradation product (guanylurea) from metformin and the antagonistic pattern recognition of combined toxicity: Insight from the pharmaceutical risk assessment and the simulated wastewater treatment
Fan Gao, Hao Wen, Sen Feng, Meng Li, Lingyun Zhu, Yongzhi Zhang, Yi‐Long Xi, Xian-Ling Xiang · 2023 · The Science of The Total Environment
Metformin: Up to Date
Silvia Maria Sciannimanico, Franco Grimaldi, Fabio Vescini, Giovanni De Pergola, Massimo Iacoviello, Brunella Licchelli, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani · 2019 · Endocrine Metabolic & Immune Disorders - Drug Targets
Toxic Effects of Penetrating Cations
С. С. Соколов, Anna N. Zyrina, Sergey A. Akimov, Дмитрий Алексеевич Кнорре, Fedor F. Severin · 2023 · Membranes
An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway
Yuanyuan Cao, Mingyi Wo, Chan Xu, Xianming Fei, Juan Jin, Zhiming Shan · 2023 · Journal of Cancer Research and Therapeutics
Epilepsy and autophagy modulators: a therapeutic split
Hayder Mutter Al-Kuraishy, Majid Sakhi Jabir, Ali Ismail Al-Gareeb, Ali K. Albuhadily, Daniel J. Klionsky, Mayyadah F. Rafeeq · 2025 · Autophagy
Metformin and Adipose Tissue: A Multifaceted Regulator in Metabolism, Inflammation, and Regeneration
Xin-Li Wei, Minghao Tao, Run-Hao Li, Shi-Hui Ge, Wei Xiao · 2025 · Endocrinology and Metabolism
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages
Hui-Hui Hu, Xuefeng Wang, Bin Lan, Haili Cheng, Hong Wen, Fangfang Chen, Jianfeng Wu, Mengqi Li, Jiazhou Chen, Jinhui Zhang et al. · 2025 · Cell Research
Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin
Shaoqian Li, Bo Xu, Shangzhi Fan, Bo Kang, Lijing Deng, Danjun Chen, Bo Yang, Fan Tang, Zunbo He, Yong Xue et al. · 2022 · Expert Review of Clinical Pharmacology
Ribavirin extends the lifespan of Caenorhabditis elegans through AMPK-TOR Signaling
Ganlan Zhang, Hui Liu, Ting Xue, Xiangming Kong, Dongmei Tian, Libo Luo, Yanhua Yang, Keqing Xu, Youheng Wei, Ziheng Zhuang · 2023 · European Journal of Pharmacology
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1
Gang Ren, Yu-Wei Ding, Lulu Wang, Jian‐Dong Jiang · 2023 · Frontiers in Pharmacology
Risk factors of using late-autophagy inhibitors: Aspects to consider when combined with anticancer therapies
Maciej Skrzeszewski, Monika Maciejewska, Dagmara Kobza, Aleksandra Gawrylak, Claudine Kiéda, Halina Waś · 2024 · Biochemical Pharmacology
Is metformin a geroprotector? A peek into the current clinical and experimental data
Agnieszka Zajda, Kristiina M. Huttunen, Joanna Sikora, Maria Podsiedlik, Magdalena Markowicz-Piasecka · 2020 · Mechanisms of Ageing and Development
Nuclear Magnetic Resonance-Based Metabolomic Analysis of the Anticancer Effect of Metformin Treatment on Cholangiocarcinoma Cells
Jin Zhang, Caihua Hang, Ting Jiang, Shenghui Yi, Wei Shao, Wengang Li, Donghai Lin · 2020 · Frontiers in Oncology
Salsalate reverses metabolic disorders in a mouse model of non‐alcoholic fatty liver disease through AMPK activation and caspase‐6 activity inhibition
Jingjing Li, Changmai Chen, Wei Zhang, Jingai Bi, Guangmin Yang, Erguang Li · 2020 · Basic & Clinical Pharmacology & Toxicology
Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review
Sami Mohamed · 2024 · Medicine
N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism
Haocheng Zhang, Yan Gu, Qiaojian Gang, Jing Huang, Qian Xiao, Xiaoqin Ha · 2023 · Frontiers in Endocrinology
Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model
Yichao Chai, Guo-Xin Dang, Hai-Qi He, Jianhua Shi, Hong-Ke Zhang, Ruitao Zhang, Bo Wang, Liangshuo Hu, Yi Lv · 2017 · World Journal of Gastroenterology
Cell biology in China: Focusing on the lysosome
Chonglin Yang, Xiao-Chen Wang · 2017 · Traffic : the International Journal of Intracellular Transport
Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review
Narges Hedayati, Zahra Oskouei, Jamshid Tabeshpour, Mehri Bemani Naeini · 2021 · European Journal of Pharmacology
Metformin exerts an antitumoral effect on papillary thyroid cancer cells through altered cell energy metabolism and sensitized by BACH1 depletion
Yang Yu, Chen Feng, Jian Kuang, Lixin Guo, Haixia Guan · 2022 · Endocrine
Striking a gut–liver balance for the antidiabetic effects of metformin
Emma Barroso, Marta Montori-Grau, Walter Wahli, Xavier Palomer, Manuel Vázquez‐Carrera · 2023 · Trends in Pharmacological Sciences
Metformin Effects on SHIP2, AMPKs and Gut Microbiota: Recent Updates on Pharmacology
Priyanka Shivaprakash, Narasimha Murthy Beeraka, SubbaRao V. Madhunapantula, Vladimir Nikolaevich Nikolenko, Kanthesh Maheshwarappa Basalingappa · 2024 · Current Medicinal Chemistry
Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
Nadia Papini, Paola Giussani, Cristina Tringali · 2024 · International Journal of Molecular Sciences
Strategy for treating MAFLD: Electroacupuncture alleviates hepatic steatosis and fibrosis by enhancing AMPK mediated glycolipid metabolism and autophagy in T2DM rats
Haoru Duan, Shanshan Song, Rui Li, Suqin Hu, Shuting Zhuang, Shaoyang Liu, Xiaolu Li, Wei Gao · 2024 · Diabetology & Metabolic Syndrome
Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions
Sindre Dahl Mediaas, Markus Haug, Claire Louet, Sissel Gyrid Freim Wahl, Alexandre Gidon, Trude Helen Flo · 2024 · Frontiers in Immunology
Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies
Manuela Sollazzo, Monica De Luise, Silvia Lemma, Licia Bressi, Maria Clara Iorio, Stefano Miglietta, Sara Milioni, Ivana Kurelac, Luisa Iommarini, Giuseppe Gasparre et al. · 2021 · FEBS Journal
Low-dose metformin and PEN2-dependent lysosomal AMPK activation: benefits outnumber side effects
Longlong Liu, Pradeep Kumar Patnana, Subbaiah Chary Nimmagadda · 2022 · Signal Transduction and Targeted Therapy
Metformin regulates ferroptosis in Skin cutaneous melanoma via ATF3/NRF2 axis
Da Gu, Yulin Sun, Jianghui Wang, Jinpeng Sun, Huanmin Lou, Weiting Kang · 2025 · Cancer Genetics
Metformin strengthens uroepithelial immunity against E. coli infection
Rakesh Kumar Majhi, Soumitra Mohanty, Witchuda Kamolvit, John Kerr White, Andrea Scheffschick, Hanna Brauner, Annelie Brauner · 2021 · Scientific Reports
Combined Effects of Methoprene and Metformin on Reproduction, Longevity, and Stress Resistance inAnastrepha ludens(Diptera: Tephritidae): Implications for the Sterile Insect Technique
Eva Aceves-Aparicio, Diana Pèrez‐Staples, José Arredondo, Aleph Alejandro Corona-Morales, Jorge É. Morales‐Mávil, Francisco Dı́az-Fleischer · 2020 · Journal of Economic Entomology
miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia
Ivo F. Machado, João Soeiro Teodoro, Ana Catarina Castela, Carlos M. Palmeira, Anabela Pinto Rolo · 2021 · International Journal of Molecular Sciences
Small-Molecule Loaded Biomimetic Biphasic Scaffold for Osteochondral Regeneration: An In Vitro and In Vivo Study
Chih-Hsiang Fang, Yi-Wen Lin, Chung-Kai Sun, Jui-Sheng Sun · 2023 · Bioengineering
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Jie Zhao, Qingya Shen, Xi-Hao Yong, Xin Li, Xiao-Wen Tian, Suyue Sun, Zheng Xu, Xiao-Yu Zhang, Luofu Zhang, Hao Yang et al. · 2025 · Nature Structural & Molecular Biology
Integrin β1-Mediated Cell–Cell Adhesion Augments Metformin-Induced Anoikis
Tingting An, Zhiming Zhang, Yuhuang Li, Jianqiao Yi, Wenhua Zhang, Deshi Chen, Juan Ao, Zhi‐Xiong Jim Xiao, Yong Yi · 2019 · International Journal of Molecular Sciences
An Update on Autophagy as a Target in the Treatment of Alzheimer’s Disease
Parnika M. Sose, Gaurav Doshi, Pravin Popatrao Kale · 2023 · Current Drug Targets
Amino acid homeostasis is a target of metformin therapy
Calum Forteath, Ify R. Mordi, Raid B. Nisr, Erika Joana Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan et al. · 2023 · Molecular Metabolism
Mechanisms of Action of Metformin
Samira Abdulla Mahmood · 2021 · IntechOpen eBooks
Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
Mingyuan Wang, Jiang Zou, Jinjin Wang, Meidong Liu, Ke Liu, Nian Wang, Kangkai Wang · 2022 · Molecular Therapy — Nucleic Acids
Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination
Yuxia Sun, Weiwei Zhang, Lu Men, Jianfeng Wu, Luming Yao, Xi Xiao Huang, Yaying Wu, Cixiong Zhang, Ying Chen, David Carling et al. · 2025 · Nature Metabolism
Highlighting the Protective or Degenerative Role of AMPK Activators in Dementia Experimental Models
Marjan Nikbakhtzadeh, Fatemeh Shaerzadeh, Ghorbangol Ashabi · 2021 · CNS & Neurological Disorders - Drug Targets
New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
Kenji Sugawara, Wataru Ogawa · 2022 · Journal of Diabetes Investigation
Plants from a semi-arid environment as a source of phytochemicals against Fusarium crown and foot rot in zucchini
Ahmed Mohamed Aly Khalil, Ahmed M. Saleh, Sayed M. S. Abo El-Souad, Mahmoud S.M. Mohamed · 2023 · AMB Express
Metformin prolongs survival rate in mice and causes increased excretion of cell-free DNA in the urine of X-irradiated rats
Serazhutdin A. Abdullaev, Gulchachak Minkabirova, Екатерина Евгеньевна Карманова, В. И. Брусков, A.I. Gaziev · 2018 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Update on: effects of anti-diabetic drugs on bone metabolism
Guillaume Mabilleau, Béatrice Bouvard · 2020 · Expert Review of Endocrinology & Metabolism
Beneficial effects of metformin on glomerular podocytes in diabetes
Dorota Rogacka, Agnieszka Piwkowska · 2021 · Biochemical Pharmacology
Metformin: Antidiabetic actions from cells to tissues
Clifford J. Bailey, Michael Gwilt, Kerstin M.G. Brand · 2026 · Metabolism
Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase
Kasandra S. Hunter, Stephen J. A. Davies · 2018 · Frontiers in Immunology
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart
Sabrina Heinz, Alexius Freyberger, Bettina Lawrenz, Ludwig Schladt, Gabriele Schmuck, Heidrun C. Ellinger-Ziegelbauer · 2019 · Archives of Toxicology
Antiobesity medications in adult and pediatric obesity and metabolic dysfunction–associated steatotic liver disease
Natalie S. Rodriguez, Phillipp Hartmann · 2025 · Pharmacological Reviews
Targeting brain connectivity in Alzheimer’s disease with repurposed drugs
Lorenzo Pini, Bruno Pietro Imbimbo, Alessandra Griffa, Gilles Allali, Nunzio Pomara · 2025 · Ageing Research Reviews
The Antidiabetic Effect of Superparamagnetic Iron Oxide Nanoparticles Highlights The Role of WNT/AMPK/mTOR/FOXO1/Mitochondrial DNA in Muscle and Kidney
Mennatallah A. Gowayed, Lamiaa M. A. Ali, Maher Abd EL-Nabi Kamel, Ghaleb A. Oriquat, Rafael Piñol, Ángel Millán, Rasha A. El-Tahan · 2023 · Nanomedicine
Real-time monitoring of glucose metabolism and effects of metformin on HepG2 cells using 13C in-cell NMR spectroscopy
Muzhou Teng, Zhijia Li, Yanmei Gu, Yitao Fan, Daijun Wang, Meiyu Liu, Yumin Li, Gang Wei, Yanjie Huang · 2023 · Biochemical and Biophysical Research Communications
New evidence: Metformin unsuitable as routine adjuvant for breast cancer: a drug-target mendelian randomization analysis
Jing‐Xuan Xu, Qi-Long Zhu, Yu-Miao Bi, Yuchong Peng · 2024 · BMC Cancer
Synthesis of metformin-derived fluorescent quantum dots: uptake, cytotoxicity, and inhibition in human breast cancer cells through autophagy pathway
Ali Akbari, Mohadeseh Nemati, Zohreh Mehri Lighvan, Fereshteh Nazari‐Khanamiri, Jafar Rezaie, Yousef Rasmi · 2024 · Journal of Biological Engineering
Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation
Junjie Fei, Shuhan Yu, Mingzhe Xu, Yang Liu, Guoqiang Wang, Xueqing Li, Xinyue Yu, Yifan Zhang, Wenhua Zhang, Yang Wang et al. · 2025 · Life Metabolism
Bioactive wet adhesive materials for oral health: strategies and applications
Geyuan Wang, Yuting Zhou, Xingjia He, Xuemei Tang, Zibo Lin, Xiaoxiao Wang, Yuxin Zhang, Xuefeng Hu, Kunneng Liang, Jieyu Zhang et al. · 2025 · Journal of Materials Chemistry B
A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer’s disease
Chen Zhang, Hao Chen, Yssa Rodriguez, Xiaowen Ma, Russell Howard Swerdlow, Jianhua Zhang, Wen‐Xing Ding · 2023 · Biochemical Pharmacology
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function
Tae Jun Lee, Yo Sasaki, Philip A. Ruzycki, Norimitsu Ban, Joseph B. Lin, Hung-Ting Wu, Andrea C. Santeford, Rajendra S. Apte · 2024 · JCI Insight
Composition of four polyphenol fractions extracted from partridge tea and their mechanisms on ameliorate insulin resistance in HepG2 cells
Ke-Xin Hao, Ying-Jing Zhang, Rui‐Fang Zhong, Yi-Meng Li, Ling Wang, Xiao Min Chang, Dawei Wang, Jianguo Jiang, Wei Zhu · 2024 · Food Bioscience
Targeting Ferroptosis in Parkinson’s: Repurposing Diabetes Drugs as a Promising Treatment
Carmen Duţă, Corina Muscurel, Carmen Beatrice Dogaru, Irina Anna-Maria Stoian · 2025 · International Journal of Molecular Sciences