Metformin activates AMPK through the lysosomal pathway

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950 · see citing works

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,788 · see citing works

Metformin: from mechanisms of action to therapies

Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.018 · Cited by 1,501 · see citing works

Metformin as a tool to target aging

Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096 · cited 1× · see citing works

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893 · see citing works

AMPK—Sensing Energy while Talking to Other Signaling Pathways

Hardie, D. G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.013 · Cited by 581 · see citing works

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Zhang, C., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y., Wu, Y., Li, T. Y., Yu, L., Lu, Z., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.014 · Cited by 546 · see citing works

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483 · see citing works

Metformin Action: Concentrations Matter

He, L., & Wondisford, F. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.003 · Cited by 448 · see citing works

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

Zhang, Y., Guo, H., Zhang, C., Lin, S., Yin, Z., Peng, Y., Luo, H., Shi, Y., Lian, G., Zhang, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.005 · Cited by 266 · see citing works

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287 · see citing works

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,177 · see citing works

AMPK signalling in health and disease

Carling, D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.01.005 · Cited by 797 · see citing works

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766 · see citing works

Metformin: update on mechanisms of action and repurposing potential

Foretz, M., Guigas, B., & Viollet, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00833-4 · Cited by 744 · see citing works

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686 · see citing works

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630 · see citing works

AMPK as a Therapeutic Target for Treating Metabolic Diseases

Day, E. A., Ford, R. J., & Steinberg, G. R. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.004 · Cited by 620 · see citing works

Metformin and Its Benefits for Various Diseases

Lv, Z., & Guo, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00191 · Cited by 544 · see citing works

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Yang, J., Zhou, Y., Xie, S., Wang, J., Li, Z., Chen, L., Mao, M., Chen, C., Huang, A., Chen, Y., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02012-7 · Cited by 386 · see citing works

Unraveling the regulation of hepatic gluconeogenesis

Zhang, X., Yang, S., Chen, J., & Su, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00802 · Cited by 314 · see citing works

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 282 · see citing works

Metformin as an Anticancer Agent

Vancura, A., Bu, P., Bhagwat, M., Zeng, J., & Vancurova, I. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.07.006 · Cited by 274 · see citing works

Metformin as Anti-Aging Therapy: Is It for Everyone?

Soukas, A. A., Hao, H., & Wu, L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.015 · Cited by 260 · see citing works

Metformin and Systemic Metabolism

He, L. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.001 · Cited by 242 · see citing works

Metformin extends C. elegans lifespan through lysosomal pathway

Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 202 · see citing works

Mitochondrial dynamics and transport in Alzheimer's disease

Flannery, P. J., & Trushina, E. V. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.009 · Cited by 198 · see citing works

25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

Xiao, J., Wang, S., Chen, L., Ding, X., Dang, Y., Han, M., Zheng, Y., Shen, H., Wu, S., Wang, M., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.021 · Cited by 207 · see citing works

The lysosome: a crucial hub for AMPK and mTORC1 signalling.

Carroll, B., & Dunlop, E. (2017) · Biochemical Journal · doi:10.1042/bcj20160780 · Cited by 173 · see citing works

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S. W., Gu, Y., Zbinden, M., Burge, M. R., Timmins, G. S., Hallows, K. R., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.028 · Cited by 194 · see citing works

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

Sharma, A., Anand, S. K., Singh, N., Dwivedi, U. N., & Kakkar, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113614 · Cited by 198 · see citing works

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Willows, R., Sanders, M. J., Xiao, B., Patel, B. R., Martin, S. R., Read, J., Wilson, J. R., Hubbard, J., Gamblin, S. J., & Carling, D. (2017) · Biochemical Journal · doi:10.1042/bcj20170458 · Cited by 190 · see citing works

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Xu, X., Sun, Y., Cen, X., Shan, B., Zhao, Q., Xie, T., Wang, Z., Hou, T., Xue, Y., Zhang, M., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00858-3 · Cited by 171 · see citing works

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Agius, L., Ford, B. E., & Chachra, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093240 · Cited by 178 · see citing works

Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

Curry, D. W., Stutz, B., Andrews, Z. B., & Elsworth, J. D. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171296 · Cited by 159 · see citing works

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Wen, Z., Jin, K., Shen, Y., Yang, Z., Li, Y., Wu, B., Tian, L., Shoor, S., Roche, N. E., Goronzy, J. J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0296-7 · Cited by 160 · see citing works

Metformin and Aging: A Review

Glossmann, H. H., & Lutz, O. M. D. (2019) · Gerontology · doi:10.1159/000502257 · Cited by 149 · see citing works

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Zhang, Y., Lanjuin, A., Chowdhury, S. R., Mistry, M., Silva-García, C. G., Weir, H. J. M., Lee, C.-L., Escoubas, C. C., Tabakovic, E., & Mair, W. B. (2019) · eLife · doi:10.7554/elife.49158 · Cited by 133 · see citing works

Metformin: A Novel Weapon Against Inflammation

Bai, B., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.622262 · Cited by 139 · see citing works

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Vara‐Ciruelos, D., Russell, F. M., & Hardie, D. G. (2019) · Open Biology · doi:10.1098/rsob.190099 · Cited by 136 · see citing works

Mitochondrial complex I as a therapeutic target for Alzheimer's disease

Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 130 · see citing works

Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry

Palacios-Rápalo, S. N., Jesús‐González, L. A. D., Cordero‐Rivera, C. D., Farfán-Morales, C. N., Osuna‐Ramos, J. F., Martínez-Mier, G., Quistián-Galván, J., Muñoz-Pérez, A., Bernal-Dolores, V., del Ángel, R. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796855 · Cited by 120 · see citing works

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

Savini, M., Zhao, Q., & Wang, M. C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.08.008 · Cited by 115 · see citing works

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Thellung, S., Corsaro, A., Nizzari, M., Barbieri, F., & Florio, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040901 · Cited by 116 · see citing works

Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment

Li, M., Li, X., Zhang, H., & Lü, Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01039 · Cited by 121 · see citing works

Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk

Paudel, Y. N., Angelopoulou, E., Piperi, C., Shaikh, M. F., & Othman, I. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104593 · Cited by 113 · see citing works

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Qu, Q., Chen, Y., Wang, Y., Wang, W., Long, S., Yang, H.-Y., Wu, J., Li, M., Tian, X., Wei, X., et al. (2024) · Nature · doi:10.1038/s41586-024-08348-2 · Cited by 126 · see citing works

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing

Prattichizzo, F., Giuliani, A., Mensa’, E., Sabbatinelli, J., Nigris, V. D., Rippo, M. R., Sala, L. L., Procopio, A. D., Olivieri, F., & Ceriello, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.003 · Cited by 111 · see citing works

Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms

Wu, Q., Wang, Q., Fu, J., & Ren, R. (2019) · Food & Function · doi:10.1039/c8fo02375a · Cited by 112 · see citing works

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Qu, Q., Chen, Y., Wang, Y., Long, S., Wang, W., Yang, H.-Y., Li, M., Tian, X., Wei, X., Liu, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08329-5 · Cited by 117 · see citing works

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Huynh, C. Q., Ryu, J., Lee, J., Inoki, A., & Inoki, K. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00648-y · Cited by 104 · see citing works

New developments in AMPK and mTORC1 cross-talk

Smiles, W. J., Ovens, A. J., Kemp, B. E., Galić, S., Petersen, J., & Oakhill, J. S. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240007 · Cited by 108 · see citing works

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202012-4510oc · Cited by 100 · see citing works

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

Camacho-Encina, M., Booth, L. K., Redgrave, R. E., Folaranmi, O., Spyridopoulos, I., & Richardson, G. D. (2024) · Cells · doi:10.3390/cells13040353 · Cited by 101 · see citing works

Autophagy and cardiac aging

Miyamoto, S. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0286-9 · Cited by 96 · see citing works

Current nutritional and pharmacological anti-aging interventions

Ros, M., & Carrascosa, J. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 95 · see citing works

AMP-activated protein kinase – not just an energy sensor

Hardie, D. G., & Lin, S. (2017) · F1000Research · doi:10.12688/f1000research.11960.1 · Cited by 87 · see citing works

Is metformin poised for a second career as an antimicrobial?

Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 87 · see citing works

Pleiotropic Effects of Metformin on Cancer

Schulten, H.-J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102850 · Cited by 86 · see citing works

The Fatty Acid Lipid Metabolism Nexus in COVID-19

Tanner, J. E., & Alfieri, C. (2021) · Viruses · doi:10.3390/v13010090 · Cited by 87 · see citing works

SIRT1 Regulation in Ageing and Obesity

Pardo, P. S., & Boriek, A. M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111249 · Cited by 90 · see citing works

Metabolic Action of Metformin

Szymczak-Pajor, I., Wenclewska, S., & Śliwińska, A. (2022) · Pharmaceuticals · doi:10.3390/ph15070810 · Cited by 81 · see citing works

Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes

Jiating, L., Buyun, J., & Zhang, Y. (2019) · BioMed Research International · doi:10.1155/2019/9203934 · Cited by 76 · see citing works

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 81 · see citing works

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Shan, C., Lu, Z., Li, Z., Sheng, H., Fan, J., Qi, Q., Liu, S., & Zhang, S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1756-1 · Cited by 72 · see citing works

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Wang, M., Tian, T., Zhou, H., Jiang, S., Jiao, Y., Zhu, Z., Xia, J., Ma, J., & Du, R. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03072-0 · Cited by 75 · see citing works

Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator

Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alnaaim, S. A., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00742-2 · Cited by 71 · see citing works

The Mechanism of Action of Biguanides: New Answers to a Complex Question

Magno, L. D., Pastena, F. D., Bordone, R., Coni, S., & Canettieri, G. (2022) · Cancers · doi:10.3390/cancers14133220 · Cited by 75 · see citing works

Metformin from mother to unborn child-are there unwarranted effects?

Nguyen, L., Chan, S.-Y., & Teo, A. K. K. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.047 · Cited by 67 · see citing works

Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells

Kim, H.-S., Ren, G., Kim, T., Bhatnagar, S., Yang, Q., Bahk, Y. Y., & Kim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70347-w · Cited by 66 · see citing works

Therapeutic Repurposing of Biguanides in Cancer

Zhao, H., Swanson, K. D., & Zheng, B. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.03.001 · Cited by 65 · see citing works

New Insights Into the Anti-Diabetic Actions of Metformin: From the Liver to the Gut

Wu, T., Horowitz, M., & Rayner, C. K. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1273769 · Cited by 64 · see citing works

AMPK signalling: Implications for podocyte biology in diabetic nephropathy

Szrejder, M., & Piwkowska, A. (2019) · Biology of the Cell · doi:10.1111/boc.201800077 · Cited by 65 · see citing works

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways

Wang, Y., Yang, Z., Zheng, G., Yu, L., Yin, Y., Mu, N., & Ma, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.002 · Cited by 63 · see citing works

Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

Speirs, C., Williams, J. J. L., Riches‐Suman, K., Salt, I. P., & Palmer, T. M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.10.001 · Cited by 61 · see citing works

Pharmacology of metformin – An update

Glossmann, H. H., & Lutz, O. M. D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172782 · Cited by 61 · see citing works

Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC

Zhang, Y., Wang, H.-B., & Xiao, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095016 · Cited by 51 · see citing works

Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

Amengual-Cladera, E., Morla-Barcelo, P. M., Morán-Costoya, A., Valle, A., Pons, D. G., Sastre‐Serra, J., Roca, P., & Nadal‐Serrano, M. (2024) · Biology · doi:10.3390/biology13050302 · Cited by 67 · see citing works

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

Russell, F. M., & Hardie, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010186 · Cited by 57 · see citing works

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

Bai, L., Li, Z., Pan, T., Wang, W., Wang, D., Turner, C., Zhou, X., & He, H. (2021) · Respiratory Research · doi:10.1186/s12931-021-01760-6 · Cited by 55 · see citing works

Metformin: Past, Present, and Future

Chaudhary, S., & Kulkarni, A. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01539-1 · Cited by 59 · see citing works

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

Justice, J. N., Gubbi, S., Kulkarni, A. S., Bartley, J. M., Kuchel, G. A., & Barzilai, N. (2020) · GeroScience · doi:10.1007/s11357-020-00261-6 · Cited by 53 · see citing works

Repurposing Antidiabetic Drugs for Cardiovascular Disease

Schubert, M., Hansen, S., Leefmann, J., & Guan, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.568632 · Cited by 54 · see citing works

A role for sodium glucose cotransporter 2 inhibitors (SGLT2is) in the treatment of Alzheimer's disease?

ESTERLINE, R. L., Oscarsson, J., & Burns, J. M. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.018 · Cited by 50 · see citing works

Regulation of organelle function by metformin

Kim, J., & You, Y. (2017) · IUBMB Life · doi:10.1002/iub.1633 · Cited by 49 · see citing works

Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

Chen, X., Wu, W., Gong, B., Hou, L., Dong, X., Xu, C., Zhao, R., Yu, Q., Zhou, Z., Huang, S., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108065 · Cited by 48 · see citing works

Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy

Nakamura, M. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.12568 · Cited by 50 · see citing works

Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia

Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022) · Pharmaceuticals · doi:10.3390/ph15030312 · Cited by 48 · see citing works

The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus

Yang, W., Sun, X., Zhang, J., & Zhang, K. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108977 · Cited by 47 · see citing works

AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake

Rao, X. S., Cong, X. X., Gao, X. K., Shi, Y. P., Shi, L., Wang, J. F., Ni, C.-Y., He, M. J., Xu, Y., Yi, C., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00809-9 · Cited by 47 · see citing works

AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules

Xiao, J., Zhu, S., Guan, H., Zheng, Y., Li, F., Zhang, X., Guo, H., Wang, X., & Ye, Z. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0254-y · Cited by 46 · see citing works

Role of p53 Family Proteins in Metformin Anti-Cancer Activities

Yi, Y., Zhang, W., Yi, J., & Xiao, Z. J. (2019) · Journal of Cancer · doi:10.7150/jca.30659 · Cited by 46 · see citing works

Challenges to Improve Bone Healing Under Diabetic Conditions

Chen, Y., Zhou, Y., Lin, J., & Zhang, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.861878 · Cited by 45 · see citing works

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Zhou, X. E., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Xu, H. E., & Melcher, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004883 · Cited by 44 · see citing works

Metformin accelerates zebrafish heart regeneration by inducing autophagy

Xie, F., Xu, S., Lü, Y., Wong, K. F., Sun, L., Hasan, K. M. M., Ma, A. C. H., Tse, G., Manno, S. H. C., Tian, L., et al. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00172-w · Cited by 44 · see citing works

New insights on the potential anti‐epileptic effect of metformin: Mechanistic pathway

Alnaaim, S. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Ali, N. H., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17965 · Cited by 42 · see citing works

Metformin as a Potential Neuroprotective Agent in Prodromal Parkinson's Disease—Viewpoint

Sportelli, C., Urso, D., Jenner, P. G., & Chaudhuri, К. R. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00556 · Cited by 45 · see citing works

Metformin attenuates sevoflurane-induced neurocognitive impairment through AMPK-ULK1-dependent autophagy in aged mice

Zhu, J., Zongze, Z., Qiuyue, Y., Peng, F., Qi, Z., Yanlin, W., & Chang, C. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.018 · Cited by 42 · see citing works

Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

Yue, F., Shi, Y., Wu, S., Lin, X., He, D., Lin, W., Qiu, A., Russell, R., & Zhang, D. (2023) · iScience · doi:10.1016/j.isci.2023.108560 · Cited by 43 · see citing works

Metformin and cognition from the perspectives of sex, age, and disease

Chaudhari, K., Reynolds, C. D., & Yang, S.-H. (2020) · GeroScience · doi:10.1007/s11357-019-00146-3 · Cited by 41 · see citing works

Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness

Nowosad, A., & Besson, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042290 · Cited by 36 · see citing works

Association of metabolic-dysfunction associated steatotic liver disease with polycystic ovary syndrome

Xu, Q., Zhang, J., Lu, Y., & Wu, L. Y. (2024) · iScience · doi:10.1016/j.isci.2024.108783 · Cited by 41 · see citing works

Spatial control of AMPK signaling at subcellular compartments

Chauhan, A. S., Li, Z., & Gan, B. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1727840 · Cited by 40 · see citing works

Relationship between Oral Metformin Use and Age-Related Macular Degeneration

Stewart, J. M., Lamy, R., Wu, F., & Keenan, J. D. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.06.003 · Cited by 39 · see citing works

Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

Franco-Juárez, B., Gómez‐Manzo, S., Hernández‐Ochoa, B., Cárdenas‐Rodríguez, N., Arreguín‐Espinosa, R., de la Cruz, V. P., & Ortega-Cuéllar, D. (2021) · Cells · doi:10.3390/cells10092359 · Cited by 38 · see citing works

Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

Nurcahyanti, A. D. R., Jap, A., Lady, J., Prismawan, D., Sharopov, F. S., Daoud, R., Wink, M., & Sobeh, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112138 · Cited by 39 · see citing works

A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19

Esam, Z. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108282 · Cited by 39 · see citing works

Cardiovascular complications of diabetes

Shah, A., Isath, A. M., & Aronow, W. S. (2022) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2099838 · Cited by 38 · see citing works

AMPK inhibits liver gluconeogenesis: fact or fiction?

Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 42 · see citing works

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

Liu, Y., Jurczak, M. J., Lear, T., Lin, B., Larsen, M. B., Kennerdell, J. R., Chen, Y., Huckestein, B. R., Nguyen, M. K., Tuncer, F., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00723-0 · Cited by 37 · see citing works

Metformina e AMPK: Um Antigo Fármaco e Uma Nova Enzima no Contexto da Síndrome Metabólica perspectivas

Cézar, A., Júnior, S., Lopes, M. R. U., Santomauro, A. T. M. G., Souto, P. D., & André, S. (2008) · Cited by 2 · see citing works

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Ma, T., Tian, X., Zhang, B., Li, M., Wang, Y., Yang, C., Wu, J., Wei, X., Qu, Q., Yu, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-04431-8 · Cited by 644 · see citing works

Metformin as an activator of AMP-activated protein kinase. Known and new mechanisms of action

Mkrtumyan, A. M., Маркова, Т. Н., Ovchinnikova, M. A., Ivanova, I. A., & Kuzmenko, K. V. (2023) · Diabetes Mellitus · doi:10.14341/dm13044 · Cited by 6 · see citing works

Metformin extends C. elegans lifespan through lysosomal pathway

Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 202 · see citing works

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works