The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Treg Cells Survive and Thrive in Inhospitable Environments
Open accessAbstract
Immune responses are dangerous by nature and require regulation to prevent inflammatory and/or autoimmune sequelae and allow healing. CD4+Foxp3+ T cells (Treg cells) play a crucial role in this process, and in this edition of Cell Metabolism, Angelin et al. (2017) describe how these cells are metabolically adapted to the job.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The majority of patients do not respond to checkpoint therapies as a result of heightened immunosuppression in the tumor microenvironment or inadequate non-self antigenic load within the tumor.
“the majority of patients do not respond as a result of heightened immunosuppression in the tumor microenvironment or inadequate non-self antigenic load within the tumor”
From LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer (2018) · cites this paper as Grzes et al., 2017
No passage from our copy matched the claim. Searches for checkpoint-therapy nonresponse, tumor immunosuppression, and non-self antigenic load also returned no passages, so the attributed explanation cannot be verified from this copy. (LLM, conf=0.68)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · cited 1×
“…and function in tissues with limited glucose concentrations or high lactate concentrations is reinforced by other studies where Treg cells have been shown to play a crucial role in the repair of renal ischemia-reperfusion injury (Gandolfo et al., 2009) or muscle damage (Burzyn et al., 2013).”
BackgroundScharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R. E., Watkins, S. C., Ferris, R. L., & Delgoffe, G. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.009 · Cited by 848
Flagged first, then by citations
Research works printed but not linked: 8
- Angelin, 2017, Cell Metab., 25, 1282, 10.1016/j.cmet.2016.12.018 · DOI
- De Rosa, 2015, Nat. Immunol., 16, 1174, 10.1038/ni.3269 · DOI
- Gandolfo, 2009, Kidney Int., 76, 717, 10.1038/ki.2009.259 · DOI
- Gerriets, 2016, Nat. Immunol., 17, 1459, 10.1038/ni.3577 · DOI
- Howie, 2017, JCI Insight, 2, e89160, 10.1172/jci.insight.89160 · DOI
- Michalek, 2011, J. Immunol., 186, 3299, 10.4049/jimmunol.1003613 · DOI · Paper page
- Preston, 2015, EMBO J., 34, 2008, 10.15252/embj.201490252 · DOI
- Wang, 2011, Immunity, 35, 871, 10.1016/j.immuni.2011.09.021 · DOI · Paper page
Cited by
Sorted by citations
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer
Tavazoie, M. F., Pollack, I., Tanqueco, R., Ostendorf, B. N., Reis, B. S., Gonsalves, F. C., Kurth, I., Andreu-Agullo, C., Derbyshire, M. L., Posada, J., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.026 · Cited by 476
“Although the clinical responses to these therapies in multiple common cancer types can be remarkably prolonged, the majority of patients do not respond as a result of heightened immunosuppression in the tumor microenvironment or inadequate non-self-antigenic load within the tumor (Grzes et al., 2017; Sharma et al., 20…”
Metadata
- Authors
- Grzes, K. M., Field, C. S., & Pearce, E. J.
- Affiliations
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- University of Freiburg (DE)
- Corresponding author
- Pearce, Edward J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 25
- Issue
- 6
- Pages
- 1213-1215
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2623945663
- Cited by
- 16
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2018: 3
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- regulatory T cells, CD4+ Foxp3+ T cells, metabolic adaptation, immune regulation, inflammation, autoimmunity
- MeSH terms
- Glucose, CD4-Positive T-Lymphocytes, Lactic Acid, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
